Abstract
In order to study its guest binding and the inclusion phenomena, 6-deoxy-6-(aminoethyl)amino-β-cyclodextrin (βCDN) was synthesised and its binding properties examined. The complexation phenomena of sodium cholate (NaC) and sodium deoxycholate (NaDC) with βCDN has been monitored by the NMR method using 13C chemical shift data. The method of continuous variation ’“Job's method” has been used to determine the stoichiometry of these supramolecular complexes. The Job's plot confirms the 1 : 1 supramolecular complex for NaC: βCDN and the 1 : 2 supramolecular complex for NaDC: βCDN. The interaction of NaC and NaDC with βCDN has been obtained through two-dimensional Rotational Nuclear Overhauser Effect Spectroscopy (ROESY) NMR. Equilibrium constants were also obtained from 13C chemical shift data (C-1, C-3 & C-4) at different pH values (7, 9, & 11).
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Singh, A.P., Cabrer, P.R., Alvarez-Parrilla, E. et al. Complexation of 6-Deoxy-6-(aminoethyl)amino-β-cyclodextrin with Sodium Cholate and Sodium Deoxycholate. Journal of Inclusion Phenomena 35, 335–348 (1999). https://doi.org/10.1023/A:1008167520548
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DOI: https://doi.org/10.1023/A:1008167520548