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Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions

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Abstract

Myxoma virus, a member of the poxvirus family of DNA viruses, encodes many virulence factors to combat and evade the host immune responses. Among the virus-encoded immuno-modulators is M-T2, a tumor necrosis factor receptor (TNF-R) homologue. M-T2 is secreted as monomeric and dimeric species that bind and inhibit rabbit TNF in a species-specific manner. Deletion analysis indicates that the anti-TNF function is mediated by the first three of four cysteine rich domains (CRDs) of M-T2. In addition, the intracellular form of M-T2 has the ability to block virus-induced apoptosis in lymphocytes, and the first two CRDs appear to be sufficient for this function. Although the mechanisms for the anti-TNF and anti-apoptotic functions of M-T2 are not yet fully defined, we postulate that these dual activities of M-T2 are mediated through different functional motifs and abrogate distinct cellular responses to virus infection.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Western Ontario and The John P. Robarts Research Institute, London, Ontario, Canada, N6G 2V4

    Xiaoming Xu, Piers Nash & Grant McFadden

  2. Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7

    Piers Nash

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  1. Xiaoming Xu
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  2. Piers Nash
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  3. Grant McFadden
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Xu, X., Nash, P. & McFadden, G. Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions. Virus Genes 21, 97–109 (2000). https://doi.org/10.1023/A:1008136431036

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