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Cyclosporins of Symmetry P21 – a Series of Clathrates

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Abstract

A series of isomorphous clathrates(cyclosporin A: solvent = 1 : 1) is reported. Thestructure of the tetrahydrofuran (1) anddibutylether (2) clathrates have been determinedby X-ray single crystal diffraction. The cyclosporinmolecules in both structures are associated via vander Waals interactions forming cavities occupied bysolvent molecules. The structure refinement based onroom-temperature data sets show significant disorderof the side chains of the cyclosporin A molecule withno adequate model of the solvent molecule in bothstructures. In contrast, the position of dibutyletherwas successfully localised using a low-temperaturedata set for 2.

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Authors and Affiliations

  1. Research Unit, Galena Co., Branišovská 31, 370 05, České Budějovice, Czech Republic

    Alexandr Jegorov

  2. Department of Solid State Chemistry, Institute of Chemical Technology, Technická 5, 166 28, Prague 6, Czech Republic

    Svetlana Pakhomova, Michal Hušák & Bohumil Kratochvíl

  3. Department of Inorganic Chemistry, Masaryk University, Kotlářská 2, 611 37, Brno, Czech Republic

    Zdirad Žák

  4. R. & D., Galena Co., 747 70, Opava-Komárov, Czech Republic

    Ladislav Cvak & Martin Buchta

Authors
  1. Alexandr Jegorov
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  2. Svetlana Pakhomova
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  3. Michal Hušák
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  4. Bohumil Kratochvíl
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  5. Zdirad Žák
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  6. Ladislav Cvak
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  7. Martin Buchta
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Jegorov, A., Pakhomova, S., Hušák, M. et al. Cyclosporins of Symmetry P21 – a Series of Clathrates. Journal of Inclusion Phenomena 37, 137–153 (2000). https://doi.org/10.1023/A:1008115029334

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  • DOI: https://doi.org/10.1023/A:1008115029334

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