An unusual sulfated fucan-like polysaccharidecontaining aminosugar constituent was isolated fromthe brown Fucales, Turbinaria ornata. Itsantiproliferative effect on asynchronous cells of ahuman non-small-cell bronchopulmonary carcinoma line(NSCLC-N6) was studied in vitro. The kinetics ofcell growth further to the continuous exposure ofcells to T. ornata extract was investigated andthe changes in the cell cycle were observed usingflow-cytometry. Cell growth appeared to be inhibitedin the G1 phase. Altogether our observations suggesta triggering of the terminal differentiation ofcancerous cells by this fucan-like polysaccharide.
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Deslandes, E., Pondaven, P., Auperin, T. et al. Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6). Journal of Applied Phycology 12, 257–262 (2000). https://doi.org/10.1023/A:1008114831862
- fucan-like polysaccharide
- bronchopulmonary carcinoma
- antiproliferative effect
- cell cycle
- brown seaweed
- Turbinaria ornata