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Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)

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Abstract

An unusual sulfated fucan-like polysaccharidecontaining aminosugar constituent was isolated fromthe brown Fucales, Turbinaria ornata. Itsantiproliferative effect on asynchronous cells of ahuman non-small-cell bronchopulmonary carcinoma line(NSCLC-N6) was studied in vitro. The kinetics ofcell growth further to the continuous exposure ofcells to T. ornata extract was investigated andthe changes in the cell cycle were observed usingflow-cytometry. Cell growth appeared to be inhibitedin the G1 phase. Altogether our observations suggesta triggering of the terminal differentiation ofcancerous cells by this fucan-like polysaccharide.

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Authors and Affiliations

  1. LEBAM-IUEM, Université de Bretagne Occidentale, place Nicolas Copernic, 29280, Plouzané, France

    E. Deslandes

  2. Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322, Nantes, Brittany, France

    P. Pondaven & C. Roussakis C

  3. Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachussetts, 02115, USA

    T. Auperin

  4. IFREMER-DRV/EP/LBMH, 29280, Plouzané, France

    J. Guézennec

  5. LEM, Université Française du Pacifique, Tahiti-P.F

    V. Stiger & C. Payri

Authors
  1. E. Deslandes
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  2. P. Pondaven
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  3. T. Auperin
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  4. C. Roussakis C
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  5. J. Guézennec
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  6. V. Stiger
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  7. C. Payri
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Deslandes, E., Pondaven, P., Auperin, T. et al. Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6). Journal of Applied Phycology 12, 257–262 (2000). https://doi.org/10.1023/A:1008114831862

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