Flavonoids extracted from the fruits of Solanum melongena (Brinjal) orally administered at a dose of 1 mg/100 g BW/day showed significant hypolipidemic action in normal and cholesterol fed rats. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol.
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Sudheesh, S., Presannakumar, G., Vijayakumar, S. et al. Hypolipidemic effect of flavonoids from Solanum melongena. Plant Foods Hum Nutr 51, 321–330 (1997). https://doi.org/10.1023/A:1007965927434