Skip to main content
SpringerLink
Log in

Hypolipidemic effect of flavonoids from Solanum melongena

Plant Foods for Human Nutrition volume 51, pages 321–330 (1997)Cite this article

Abstract

Flavonoids extracted from the fruits of Solanum melongena (Brinjal) orally administered at a dose of 1 mg/100 g BW/day showed significant hypolipidemic action in normal and cholesterol fed rats. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Ahmad F, Khan MM, Rastogi AK, Chaubey M, Kidwai JR (1991) Effect of (—)epicatechin on cAMP content, insulin release and conversion of proinsulin to insulin in immature and mature rat islets in vitro. Ind J Exp Biol 29: 516-520.

    CAS  Google Scholar 

  2. Linn BB, Chen H, Huang PC (1986) Effect of instant panchong tea, catechin and caffeine on serum cholesterol and serum low density lipoprotein in mice. Nutr Rep Int 34: 821- 829.

    Google Scholar 

  3. Matsuda H, Chisaka T, Kubumura Y, Yamahara J, Sawada T, Fujima H, Kimura H (1986) Effects of crude drugs on experimental hypercholesterolemia1Tea and its active principles. J Ethnopharmacol 17: 213-224.

    Article  CAS  Google Scholar 

  4. Yugarani T, Tan BKH, Teh M, Das NP (1992) Effect of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Lipids 27: 181-186.

    Article  CAS  Google Scholar 

  5. Middleton Jr E., Kandaswami C (1994) Potential health promoting properties of citrus flavonoids. Food Technology 48: 115-119.

    CAS  Google Scholar 

  6. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease. Lancet 342: 1007-1011.

    Article  CAS  Google Scholar 

  7. Sharma RD (1984) Hypocholesterolemic effect of hydroxy acid components of Bengal gram. Nutr Rep Int 29: 1315-1322.

    CAS  Google Scholar 

  8. Rizvi SI, Zaid AM, Suhad M (1995) Insulin mimetic effect of (—)epicatechin on osmotic fragility of human erythrocytes. Ind J Exp Biol 33: 791-792.

    CAS  Google Scholar 

  9. Ikeda I, Imasato Y, Sasaki E, Nakayama M, Nagao H, Takeo T, Yayabe F, Sugano M (1992) Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. Biochim Biophys Acta 1127: 141-146.

    CAS  Google Scholar 

  10. Sudheesh S (1996) Studies on the effect of pectins and condensed tannins on metabolism. PhD thesis, University of Kerala, India.

    Google Scholar 

  11. Das DK (1994) Naturally occurring flavonoids, structure, chemistry and high performance liquid chromatography methods for separation and characterization. Methods in Enzymology (New York) 234: 410-437.

    Article  CAS  Google Scholar 

  12. Singleton VL, Rossi JA (1965) Calorimetry of total phenolics with phosphomolybdicphosphotungstic acid regent. Am J Enol Vitic 16: 144-158.

    CAS  Google Scholar 

  13. Radin N (1981) Extraction of lipids with hexane-isopropanol. Methods in Enzymology (New York) 72: 5-7.

    Article  CAS  Google Scholar 

  14. Gomathy R, Vijayalakshmi NR, Kurup PA (1989) Hypolipidemic principles of inflorescence stalk of plantain (Musa sapientum). J Biosci 14: 301-309.

    Article  CAS  Google Scholar 

  15. Kornberg A, Horecker CB (1955) Glucose-6-phosphate dehydrogenase. Methods in Enzymology (New York) 1: 323-327.

    Article  CAS  Google Scholar 

  16. Ochoa S (1955) Malic enzyme. Methods in Enzymology (New York) 1: 739-753.

    Article  CAS  Google Scholar 

  17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275.

    CAS  Google Scholar 

  18. Bennet CA, Franklin NL (1967) Statistical analysis in chemistry and chemical industry, pp 133-138. New York: John Wiley and Sons.

    Google Scholar 

  19. Patsy MN, Barbara OS, Richard AF (1991) Effect of dietary fibers on nonfasting plasma lipoprotein and apolipoprotein levels in rats. J Nutr 121: 431-437.

    Google Scholar 

  20. Valsa AK, Usha Kumari B, Vijayalakshmi NR (1995) Effect of catechin on lipid metabolism. J Clin Biochem Nutr 19: 175-182.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-, 695 581, India

    S. Sudheesh, G. Presannakumar, S. Vijayakumar & N. R. Vijayalakshmi

Authors
  1. S. Sudheesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Presannakumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Vijayakumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. R. Vijayalakshmi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sudheesh, S., Presannakumar, G., Vijayakumar, S. et al. Hypolipidemic effect of flavonoids from Solanum melongena. Plant Foods Hum Nutr 51, 321–330 (1997). https://doi.org/10.1023/A:1007965927434

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1007965927434

search

Navigation