Plant Foods for Human Nutrition

, Volume 51, Issue 4, pp 321–330 | Cite as

Hypolipidemic effect of flavonoids from Solanum melongena

  • S. Sudheesh
  • G. Presannakumar
  • S. Vijayakumar
  • N. R. Vijayalakshmi


Flavonoids extracted from the fruits of Solanum melongena (Brinjal) orally administered at a dose of 1 mg/100 g BW/day showed significant hypolipidemic action in normal and cholesterol fed rats. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol.

Solanum melongena Flavonoid HMG CoA Glucose-6-phosphate dehydrogenase Malate dehydrogenase Lipoproteinlipase LCAT 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • S. Sudheesh
    • 1
  • G. Presannakumar
    • 1
  • S. Vijayakumar
    • 1
  • N. R. Vijayalakshmi
    • 1
  1. 1.Department of BiochemistryUniversity of KeralaKariavattom, Thiruvananthapuram-India

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