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Reaction of β-Cyclodextrin with N-2,3-Epoxypropylphthalimide. Preparation, Characterisation and Study of a New Substituted Cycloheptaamylose. Effects on the Water Solubility of Drugs

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Abstract

The reaction of β-cyclodextrinwith N-2,3-epoxypropylphthalimide yielded a set of newamorphous host compounds with high solubility whichwas transmitted to the corresponding host-guestcomplexes. The structure was determined by comparing the 1H- and 13C-NMR spectra with those of theparent compound, the degree of substitution by integration of the corresponding NMR signals, and C, H,and N elemental analysis.

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References

  1. J. Szejtli: Cyclodextrins and their Inclusion Complexes, Akademiai Kiado, Budapest (1982); J. Szejtli: Cyclodextrin Technology, Kluwer Academic Puуlishers, Dordrecht (1988).

    Google Scholar 

  2. R. Van Etten, J. Seуastian, G. Cloves, and M. Bender: J. Am. Chem. Soc. 89, 3242 (1967) A. Heredia, G. Requena and F. Garcia-Sánchez: J. Chem. Soc., Chem. Commun. 1914 (1985).

    Google Scholar 

  3. A. Wishnia and S. Lappi: J. Mol. Biol. 87, 77 (1974).

    Google Scholar 

  4. I. Taуushi, Y. Kuroda and T. Mizutani: J. Am. Chem. Soc. 108, 4514 (1986).

    Google Scholar 

  5. C. Jaime, J. Redondo, F. Sánchez-Ferrando and A. Virgili: J. Org Chem. 55, 4772 (1990); J. Riуó, J.A. Farrera, M.L. Valero and A. Virgili: Tetrahedron 51, 3705 (1995).

    Google Scholar 

  6. D. Salvatierra, C. Diez and C. Jaime: J. Incl. Phenom. 27, 215 (1997); D. Wood, F. Hruska and W. Saenger: J. Am. Chem. Soc. 99, 1735 (1977); Y. Inove, Y. Catono, and R. Chujo: Bull. Chem. Soc. Jpn. 52, 1692 (1979).

    Google Scholar 

  7. J. Pitha and J. Pitha: J. Pharm. Sci. 74, 987 (1985).

    Google Scholar 

  8. O.I. Corrigan, M.A. Forvar and W.I. Higuchi: Int. J. Pharm. 5, 229 (1980).

    Google Scholar 

  9. J. Pitha, J. Milecki, H. Fales, L. Panell and K. Uekama: Int. J. Pharm. 29, 73 (1986).

    Google Scholar 

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Authors and Affiliations

  1. Unitat de Química Orgànica, Departament de Química, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain

    RAQUEL DELGADO & ALBERT VIRGILI

  2. Hospitalet del Llobregat, Lipotec S.A, Santa Eulalia 236, 08902, Barcelona, Spain

    J. M. GARCIA-ANTON & A. PARENTE

Authors
  1. RAQUEL DELGADO
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  2. ALBERT VIRGILI
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  3. J. M. GARCIA-ANTON
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  4. A. PARENTE
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DELGADO, R., VIRGILI, A., GARCIA-ANTON, J.M. et al. Reaction of β-Cyclodextrin with N-2,3-Epoxypropylphthalimide. Preparation, Characterisation and Study of a New Substituted Cycloheptaamylose. Effects on the Water Solubility of Drugs. Journal of Inclusion Phenomena 28, 205–212 (1997). https://doi.org/10.1023/A:1007928520661

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  • DOI: https://doi.org/10.1023/A:1007928520661

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