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Principles of Combination Therapy for Hypertension: What we Learn from the HOT and Other Studies— A Personal Point of View

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Abstract

With the publication of the HOT study, the desirable diastolic blood pressure in hypertensives has dropped to between 80 and 85 mmHg. To achieve such low levels requires combination therapy in the majority. Combination therapy is set to become standard practice in the management of hypertension, so that it is now appropriate to consider the principles involved.

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Authors and Affiliations

  1. Medical Research Council Heart Research Group, Cape Heart Centre, University of Cape Town, Observatory 7925, Cape Town, South Africa

    Lionel H. Opie

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  1. Lionel H. Opie
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Opie, L.H. Principles of Combination Therapy for Hypertension: What we Learn from the HOT and Other Studies— A Personal Point of View. Cardiovasc Drugs Ther 12, 425–429 (1998). https://doi.org/10.1023/A:1007789629484

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