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Acute Effects of Celiprolol on Angiographically Normal and Stenotic Coronary Arteries

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Abstract

Unselective and β_1-selective beta-blockers may induce vasoconstriction of normal and stenotic epicardial coronary arteries. To analyze the influence of the vasodilatory beta-blocker celiprolol on coronary vasomotility, 0.4 mg celiprolol/kg were intravenously infused over 4 minutes in 13 patients with coronary artery disease. Coronary angiograms were taken before (control) and at 4, 6, 8, 10, 15, and 20 minutes after the onset of infusion and 4 minutes after final sublingual administration of 0.4 mg nitroglycerin. Quantitative analysis of cinefilms demonstrated no significant diameter changes in angiographically normal coronary segments and stenoses. The vasodilatory capacity of normal segments (18 ± 12%; p ` 0.001) and stenoses (17 ± 14%; p ` 0.01) was proven by nitroglycerin. Systolic blood pressure, heart rate, and pulmonary wedge pressure revealed no significant changes with celiprolol. Thus, celiprolol exerts no vasoconstricting effects on angiographically normal and stenotic coronary arteries.

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References

  1. Robertson RM, Wood AJJ, Vaughn WK, Robertson D. Exacerbation of vasotonic angina pectoris by propranolol. Circulation 1982;65:281–285.

    Google Scholar 

  2. Cieslinski G, Hopf R, Kober G, Kaltenbach M. Can β-blockers trigger coronary spasms? Deutsch Med Wochenschr 1987;112:593–596.

    Google Scholar 

  3. Tilmant PY, Lablanche JM, Thieuleux FA, Dupuis BA, Bertrand ME. Detrimental effect of propranolol in patients with coronary arterial spasm countered by combination with diltiazem. Am J Cardiol 1983;52:230–233.

    Google Scholar 

  4. Vatner S, Hintze THH. Mechanism of constriction of large coronary arteries by β-adrenergic receptor blockade. Circ Res 1983;3:389–400.

    Google Scholar 

  5. Rafflenbeul W, Berger C, Lichtlen P. Einfluβ von Beta-Rezeptorenblockern auf Koronargefäße. In: Grosdanoff P, Kaindl F, Kraupp O, et al. Beta-Rezeptoren und Beta-Rezeptorenblocker. Berlin: Walter de Gruyter, 1988:179–186.

    Google Scholar 

  6. Brown BG, Bolson EL, Dodge HR. Dynamic mechanisms in human coronary stenosis. Circulation 1984;70:917–922.

    Google Scholar 

  7. Bortone AS, Hess OM, Gaglione A, et al. Effect of intravenous propranolol on coronary vasomotion at rest and during dynamic exercise in patients with coronary artery disease. Circulation 1990;81:1225–1235.

    Google Scholar 

  8. Rafflenbeul W, Berger C, Jost S. Vasoconstriction of epicardial coronary arteries with selective and nonselective β-blockers (abstr). Circulation 1988;78(Suppl II):II36.

    Google Scholar 

  9. Marmo E, Filippelli A, Matera C, et al. Celiprolol, a new beta-blocking agent that modulates adrenergic receptors: Experimental in vitro research. Curr Therap Res 1986;30:475–486.

    Google Scholar 

  10. Pruss TP, Khandwala A, Wolf PS, Grebow P, Wong L. Celiprolol: A new beta adrenoceptor antagonist with novel ancillary properties. J Cardiovasc Pharmacol 1986;8(Suppl 4):S29–S32.

    Google Scholar 

  11. Taylor SH. Beta-blocking drugs and myocardial function. J Cardiovasc Pharmacol 1986;8(Suppl 4):S75–S82.

    Google Scholar 

  12. Frishmen WH, Heimann M, Soberman J, Greenberg S, Eff J, for the Celiprolol International Angina Study Group. Comparison of celiprolol and propranolol in stable angina pectoris. Am J Cardiol 1991;67:665–670.

    Google Scholar 

  13. Eff J, Godfrey J, Garutti R, Capone P. Celiprolol in angina pectoris: A controlled study. J Cardiovasc Pharmacol 1986;8(Suppl 4):S132–S134.

    Google Scholar 

  14. Frohlich ED. Vasodilatory β-blockers: Systemic and regional hemodynamic effects. Am Heart J 1991;121:1012–1017.

    Google Scholar 

  15. Tsukiyama H, Otsuka K, Horii M. Haemodynamic effects of new β-blockers with vasodilatory properties in essential hypertension. Drugs 1988;36:48–54.

    Google Scholar 

  16. Jost S, Rafflenbeul W, Gerhardt U, et al. Influence of ionic and non-ionic radiographic contrast media on the vasomotor tone of epicardial coronary arteries. Eur Heart J 1989;10(Suppl F):60–65.

    Google Scholar 

  17. Silke B, Verma SP, Frais MA, Reynolds G, Taylor SH. Comparative effects of metoprolol and celiprolol on cardiac hemodynamics and left ventricular volume at rest and during exercise-induced angina. Clin Pharmacol Ther 1986;39:5–14.

    Google Scholar 

  18. Austen WG, Edwards JE, Frye RL, et al. A reporting system on patients evaluated for coronary artery disease: Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975;51:5–40.

    Google Scholar 

  19. Reiber JHC, Serruys PW, Kooijman CJ, et al. Assessment of short-, medium-and long-term variations in arterial dimensions from computer-assisted quantitation of coronary cineangiograms. Circulation 1985;71:280–288.

    Google Scholar 

  20. Jost S, Rafflenbeul W, Reil GH, et al. Reproducible uniform coronary vasomotor tone with nitrocompounds: Prerequisite of quantitative coronary angiographic trials. Cathet Cardiovasc Diagn 1990;20:168–173.

    Google Scholar 

  21. Prida XE, Feldman RL, Hill JA, Pepine CJ. Comparison of selective beta-1 and nonselective (beta1 and beta2) beta-adrenergic blockade on systemic and coronary hemodynamic findings in angina pectoris. Am J Cardiol 1987; 60:244–248.

    Google Scholar 

  22. Gaglione A, Hess OM, Corin WJ, Ritter M, Grimm J, Krayenbühl HP. Is there coronary vasoconstriction after intracoronary beta-adrenergic blockade in patients with coronary artery disease? J Am Coll Cardiol 1987;10:299–310.

    Google Scholar 

  23. Feigl EO. The paradox of adrenergic coronary vasoconstriction. Circulation 1987;76:737–745.

    Google Scholar 

  24. Heusch G. Alpha-adrenergic mechanisms in myocardial ischemia. Circulation 1990;81:1–13.

    Google Scholar 

  25. Rimele TJ, Rooke TW, Aarhus LL, Vanhoutte PM. Alpha-1 adrenoceptors and calcium in isolated canine coronary arteries. J Pharmacol Exp Ther 1983;226:668–672.

    Google Scholar 

  26. Kaski JC, Rodriguez-Plaza L, Brown J, Maseri A. Efficacy of carvedilol (BM 14, 190), a new beta-blocking drug with vasodilating properties in exercise-induced ischemia. Am J Cardiol 1985;56:35–40.

    Google Scholar 

  27. Silke B, Verma SP, Frais MA, Reynolds G, Taylor SH. Differential actions of atenolol and celiprolol on cardiac performance in ischemic heart disease. J Cardiovasc Pharmacol 1986;8(Suppl 4):S138–S144.

    Google Scholar 

  28. Heublein B, Modersohn D, Franz N, Panzner B. Acute haemodynamic profile of celiprolol in patients with coronary heart disease and hypertension: A double-blind comparison with metoprolol. Eur Heart J 1991;12:617–623.

    Google Scholar 

  29. McLenachan JM, Dargie HJ. A review of the clinical experience with celiprolol in angina. Am Heart J 1991;121:688–690.

    Google Scholar 

  30. Modersohn D, Franz N, Heublein B, Panzner B, Walde T, Bruch L. Acute influence of beta-adrenergic antagonists on left ventricular diastolic function: Contrasting results after administration of celiprolol and metoprolol. J Hum Hypertens 1994;8:127–132.

    Google Scholar 

  31. Porter TR, Sears T, Xie F, et al. Intravascular ultrasound study of angiographically mildly diseased coronary arteries. J Am Coll Cardiol 1993;22:1858–1865.

    Google Scholar 

  32. Yamagishi M, Nissen SE, Booth DC, et al. Coronary reactivity to nitroglycerin: Intravascular ultrasound evidence for the importance of plaque distribution. J Am Coll Cardiol 1995;25:224–230.

    Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Hannover Medical School, Hannover, Germany

    Stefan Jost, Dirk Hausmann, Peter Lippolt & Matthias Sturm

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  1. Stefan Jost
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  2. Dirk Hausmann
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  3. Peter Lippolt
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  4. Matthias Sturm
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Jost, S., Hausmann, D., Lippolt, P. et al. Acute Effects of Celiprolol on Angiographically Normal and Stenotic Coronary Arteries. Cardiovasc Drugs Ther 11, 133–138 (1997). https://doi.org/10.1023/A:1007780713915

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