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Probucol Inhibits Neointimal Formation in Carotid Arteries of Normocholesterolemic Rabbits and the Proliferation of Cultured Rabbit Vascular Smooth Muscle Cells

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References

  1. Moore S. Endothelial injury and atherosclerosis. Exp Mol Pathol 1979;31:182-190.

    Google Scholar 

  2. Steele PM, Chesebro JH, Stanson AW, Holmes DR Jr., Dewanjee MK, Badimon L, Fuster V. Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. Circ Res 1985;57:105-112.

    Google Scholar 

  3. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983;49:327-333.

    Google Scholar 

  4. Hassler O. The origin of the cells constituting arterial intima thickening: An experimental autoradiographic study with the use of H3-thymidine. Lab Invest 1970;22:286-293.

    Google Scholar 

  5. Ross R. The pathogenesis of atherosclerosis-an update. N Engl J Med 1986;314:488-500.

    Google Scholar 

  6. Essed CE, Van den Brand M, Becker AE. Transluminal coronary angioplasty and early restenosis. Fibrocellular occlusion after wall laceration. Br Heart J 1983;49:393-396.

    Google Scholar 

  7. Forrester JS, Fishbein M, Helfant R, Fagin J. A paradigm for restenosis based on cell biology: Clues for the development of new preventive therapies. J Am Coll Cardiol 1991;17:758-769.

    Google Scholar 

  8. Kaltenbach M, Kober G, Scherer D, Vallbracht C. Recurrence rate after successful coronary angioplasty. Eur Heart J 1985;6:276-281.

    Google Scholar 

  9. Serruys PW, Luijiten HE, Beatt KJ, et al. Incidence of restenosis after successful coronary angioplasty: A time-related phenomenon. A quantitative angiographic study in 342 consective patients at 1, 2, 3, and 4 months. Circulation 1988;77:361-371.

    Google Scholar 

  10. Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty: A study in the normal rabbit and the hypercholesterolemic Yukatan Micropig. Circulation 1994;89:2816-2821.

    Google Scholar 

  11. KakutaT, CurrierJW, Haudenschild CC, Ryan TJ, Faxon DP. Differences in compensatory enlargement, not intimal formation, account for restenosis after angioplasty in the atherosclerotic rabbit model. Circulation 1994;89:2809-2815.

    Google Scholar 

  12. Post MJ, Borst C, Pasterkamp G, Haudenschild CC. Arterial remodeling in atherosclerosis and restenosis: A vague concept of a distinct phenomenon. Atherosclerosis 1995; 118(Suppl.):S-115-123.

    Google Scholar 

  13. Serruys PW, de Jaegere P, Kiemeneij F, et al. for the Benestent Study Group. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 1994;331: 489-495.

    Google Scholar 

  14. Fischman DL, Leon MB, Baim DS, et al. for the Stent Restenosis Study investigators. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994;331:496-501.

    Google Scholar 

  15. Santoian EC, King SB III. Intravascular stents, intimal proliferation and restenosis. J Am Coll Cardiol 1992;19: 877-879.

    Google Scholar 

  16. Bai H, Masuda J, Sawa Y, et al. Neointimal formation after vascular stent implantation: Spatial and chronological distribution of smooth muscle cell proliferation and phenotypic moduration. Arterioscler Thromb 1994;14:1846-1853.

    Google Scholar 

  17. Buckley MM, Goa KL, Price AH, Brogden RN. Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolemia. Drugs 1989;37:761-800.

    Google Scholar 

  18. Kisanuki A, Asada Y, Hatakeyama K, Hayashi T, Sumiyoshi A. Contribution of the endothelium to intimal thickening in normocholesterolemic and hypercholesterolemic rabbits. Arterioscler Thromb 1992;12:1198-1205.

    Google Scholar 

  19. Schneider JE, Berk BC, Gravanis MB, et al. Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis. Circulation 1993;88:628-637.

    Google Scholar 

  20. Gordon AAF, Louise F, Anne SL, Matthew K, Jaffar NZ, Erik EA. Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit. Proc Natl Acad SciUSA 1992;89:11312-11316.

    Google Scholar 

  21. Karas SP, Gravanis MB, Santoian EC, Robinson KA, Anderberg KA, King SB III. Coronary intimal proliferation after balloon injury and stenting in swine: An animal model of restenosis. J Am Coll Cardiol. 1992;20:467-474.

    Google Scholar 

  22. Ferns GA, Stewart-Lee AL, Anggard EE. Arterial response to mechanical injury: Balloon catheter de-endothelialization. Atherosclerosis 1992;92:89-104.

    Google Scholar 

  23. Shinomiya M, Shirai K, Saito Y, Yoshida S. Inhibition of intimal thickening of the carotid artery of rabbits and of outgrowth of explants of aorta by probucol. Atherosclerosis 1992;97:143-148.

    Google Scholar 

  24. Ohtani H, Hayashi K, Hirata Y, et al. Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. J Lipid Res 1990;31:1413-1422.

    Google Scholar 

  25. Waksman R, Robinson KA, Crocker IR, Gravanis MB, Cipolla GD, King SB III. Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine. A possible role for radiation therapy in restenosis prevention. Circulation 1995;91:1533-1539.

    Google Scholar 

  26. Bierman EL, Stein O, Stein Y. Lipoprotein uptake and metabolism by rat aortic smooth muscle cells in tissue culture. Circ Res 1974;35:136-150.

    Google Scholar 

  27. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K. A combined assay of cell viability and in vitro cytotoxity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull 1996;19:1518-1520.

    Google Scholar 

  28. Lowry OH, Rosebrough NJ, Rass AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:268-275.

    Google Scholar 

  29. Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986;233:305-312.

    Google Scholar 

  30. Fruebis J, Steinberg D, Dresel HA, Carew TE. A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits. J Clin Invest 1994;94:392-398.

    Google Scholar 

  31. Fellin R, Gasparotto A, Valerio G, et al. Effect of probucol treatment on lipoprotein cholesterol and drug levels in blood and lipoproteins in familial hypercholesterolemia. Atherosclerosis 1986;59:47-56.

    Google Scholar 

  32. Cowley S, Paterson H, Kemp P, Marshall CJ. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994;77:841-852.

    Google Scholar 

  33. Watson MH, Venance SL, Pang SC, Mak AS. Smooth muscle cell proliferation: Expression and kinase activities of p34cdc2 and mitogen-activated protein kinase homologues. Circ Res 1993;73:109-117.

    Google Scholar 

  34. Duff JL, Berk BC, Corson MA. Angiotensin II stimulate the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 1992;188:257-264.

    Google Scholar 

  35. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993;268:14553-14556.

    Google Scholar 

  36. Kariya K, Kawahara Y, Tsuda T, Fukuzaki H, Takai Y. Possible involvement of protein kinase C in platelet-derived growth factor-stimulated DNA synthesis in vascular smooth muscle cells. Atherosclerosis 1987;63: 251-255.

    Google Scholar 

  37. Takagi Y, Hirata Y, Tanaka S, Yoshimi H, Fukuda Y, Fujita T, Hidaka H. Effects of protein kinase inhibitors on growth factor-stimulated DNA synthesis in cultured rat vascular smooth muscle cells. Atherosclerosis 1988;74:227-230.

    Google Scholar 

  38. Williams LT. Signal transduction by the platelet-derived growth factor receptor. Science 1989;243:1564-1570.

    Google Scholar 

  39. Boscoboinik D, Szewczyk A, Hensey C, Azzi A. Inhibition of cell proliferation by a-tocopherol. Role of protein kinase C. J Biol Chem 1991;266:6188-6194.

    Google Scholar 

  40. Mahoney CW, Azzi A. Vitamine E inhibits protein kinase C activity. Biochim Biophys Res Commun 1988;154:694-697.

    Google Scholar 

  41. Chatelain E, Boscoboinik DO, Bartoli GM, Kagan VE, Gey FK, Packer L, Azzi A. Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochim Biophys Acta 1993;1176: 83-89.

    Google Scholar 

  42. Rao GN, Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res 1992;70:593-599.

    Google Scholar 

  43. Rao GN, Lassegue B, Griendling KK, Alexander RW, Berk BC. Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: Role of protein kinase C. Nucleic Acids Res 1993;21:1259-1263.

    Google Scholar 

  44. Cynshi O, Takashima Y, Katoh Y, Tamura K, Sato M, Fujita Y. Action of phenolic antioxidants on various active oxygen species. J Biolumin Chemilumin 1995;10:261-269.

    Google Scholar 

  45. Huang DL, Latus LJ, Lev-Ran A. Effects of platelet-contained growth factors (PDGF, EGF, IGF-1, and TGF-α on DNA synthesis in porcine aortic smooth muscle cells in culture. Exp Cell Res 1992;200:358-360.

    Google Scholar 

  46. Crowley ST, Dempsey EC, Horwitz KB, Horwitz LD. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth ampliFIcation factors serotonin and adenosine diphosphate. Circulation 1994;90:1908-1918.

    Google Scholar 

  47. Bell L, Madri JA. Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circ Res 1985;65:1057-1065.

    Google Scholar 

  48. Rao GN, Alexander RW, Runge MS. Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. J Clin Invest 1995;96:842-847.

    Google Scholar 

  49. Waller BF, Pinkerton CA, Orr CM, Slack JD, VanTassel JW, Peters T. Morphological observations late (greater than 30 days) after clinically successful coronary balloon angioplasty. Circulation 1991;83(Suppl.):I28-I41.

    Google Scholar 

  50. Austin GE, Ratliff NB, Hollman J, Tabei S, Phillips DF. Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty. J Am Coll Cardiol 1985;6:369-375.

    Google Scholar 

  51. Ueda M, Becker AE, Tsukada T, Numano F, Fujimoto T. Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition. Circulation 1991;83:1327-1332.

    Google Scholar 

  52. Lee YJ, Daida H, Yokoi H, et al. Effectiveness of probucol in preventing restenosis after percutaneous transluminal coronary angioplasty. Jpn Heart J 1996;37:327-332.

    Google Scholar 

  53. Watanabe K, Sekiya M, Ikeda S, Miyagawa M, Hashida K. Preventive effects of probucol on restenosis after percutaneous transluminal coronary angioplasty. Am Heart J 1996;132:23-29.

    Google Scholar 

  54. Tardif JC, Cote G, Lesperance J, et al. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group. N Engl J Med 1997;337:365-372.

    Google Scholar 

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Authors and Affiliations

  1. First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan

    Koichi Tanaka, Kozo Hayashi, Tetsuji Shingu, Yoshio Kuga, Katsuhiko Nomura & Goro Kajiyama

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  1. Koichi Tanaka
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Tanaka, K., Hayashi, K., Shingu, T. et al. Probucol Inhibits Neointimal Formation in Carotid Arteries of Normocholesterolemic Rabbits and the Proliferation of Cultured Rabbit Vascular Smooth Muscle Cells. Cardiovasc Drugs Ther 12, 19–28 (1998). https://doi.org/10.1023/A:1007777128574

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