Skip to main content
SpringerLink
Log in

Lowering of Serum Cholesteryl Ester Transfer Protein—But Not Lecithin:Cholesterol Acyltransferase—Activity Levels by Hypocholesterolemic Drugs in the Rabbit

  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986;232:34-37.

    Google Scholar 

  2. Shih DM, Gu L, Hama S, et al. Genetic-dietary regulation of serum praoxonase expression and its role in atherogenesis in a mouse model. J Clin Invest 1996;97:1630-1639.

    Google Scholar 

  3. Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res 1995;36:211-228.

    Google Scholar 

  4. Tall AR. Plasma cholesteryl ester transfer protein (review). J Lipid Res 1993;34:1255-1274.

    Google Scholar 

  5. Steinberg D. A docking receptor for HDL cholesterol esters. Science 1996;271:460-461.

    Google Scholar 

  6. Hayek T, Masucci-Magoulas L, Jiang X, et al. Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene. J Clin Invest 1995;96:2071-2074.

    Google Scholar 

  7. Ha YC, Barter PJ. Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. Comp Biochem Physiol 1982;71B:265-269.

    Google Scholar 

  8. Zilversmit DB. Lipid transfer proteins. J Lipid Res 1984;25: 1563-1569.

    Google Scholar 

  9. Son YSC, Zilversmit DB. Increased lipid transfer activities in hyperlipidemic rabbit plasma. Arteriosclerosis 1986;6: 345-351.

    Google Scholar 

  10. Groener, JEM, Van Ramshorst EM, Katan MB, Mensink RP, Van Tol A. Diet-induced alteration in the activity of plasma lipid transfer protein in normolipidemic human subjects. Atherosclerosis 1991;87:221-226.

    Google Scholar 

  11. Hoffman WF, Alberts AW, Anderson PS, Chen JS, Smith RL, Willard AK. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivates of mevinolin. J Med Chem 1986;29:849-852.

    Google Scholar 

  12. Cighetti G, Bosisio E, Galli G, Galli-Kienle M. The effect of cholestyramine on liver HMG-CoA reductase and cholesterol 7α-hydroxylase in various laboratory animals. Life Sci 1983;33:2483-2488.

    Google Scholar 

  13. Andersen JM, Turley SD, Dietschy JM. Relative rates of sterol synthesis in the liver and various extrahepatic tissues of normal and cholesterol-fed rabbits. Relationship to plasma lipoprotein and tissue cholesterol levels. Biochim Biophys Acta 1982;711:421-430.

    Google Scholar 

  14. Van Lith HA, Meijer GW, Haller M, Beynen AC. Serum pseudocholinesterase activity in rabbits fed simvastatin. Biochem Pharmacol 1991;41:460-461.

    Google Scholar 

  15. Meijer GW, Van der Palen JGP, De Vries H, et al. Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits. J Lipid Res 1992;33:281-286.

    Google Scholar 

  16. Beynen AC, West CE, Katan MB, Van Zutphen LFM. Hyperresponsiveness of plasma cholesterol to dietary cholesterol, saturated fatty acids and casein in inbred rabbits. Nutr Rep Int 1986;33:65-70.

    Google Scholar 

  17. Terpstra AHM, Woodward CJH, Sanchez-Muniz FJ. Improved techniques for the separation of serum lipoproteins by density gradient ultracentrifugation: Visualization by pre-staining and rapid separation of serum lipoproteins from small volumes of serum. Anal Biochem 1981;111:149-157.

    Google Scholar 

  18. Sullivan DR, Kruijswijk Z, West CE, Kohlmeier M, Katan MB. Determination of serum triglycerides by an accurate enzymatic method not affected by free glycerol. Clin Chem 1985;31:1227-1228.

    Google Scholar 

  19. Speijer H, Groener JEM, Van Ramshorst E, Van Tol A. Different locations of cholesteryl ester transfer protein and phospholipid transfer protein activities in plasma. Atherosclerosis 1991;90:159-168.

    Google Scholar 

  20. Groener JEM, Pelton RW, Kostner GM. Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma. Clin Chem 1986;32:283-286.

    Google Scholar 

  21. Glomset JA, Wright JL. Some properties of a cholesterol esterifying enzyme in human plasma. Biochim Biophys Acta 1964;89:266-276.

    Google Scholar 

  22. Meijer GW, Demacker PNM, Van Tol A, et al. Plasma activities of lecithin-cholesterol acyltransferase, lipid transfer proteins and post-heparin lipases in inbred strains of rabbits hypo-responsive or hyper-responsive to dietary cholesterol. Biochem J 1993;293:729-734.

    Google Scholar 

  23. Quig DW, Zilversmit DB. Dissociation between cholesterol secretion and plasma lipid transfer activity in rabbits. FASEB J 1988;2:2712-2716.

    Google Scholar 

  24. Ahnadi CE, Berthezène F, Ponsin G. Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects. Atherosclerosis 1993;99:219-228.

    Google Scholar 

  25. Hibino T, Sakuma N, Sato T, Yoneyama A, Fujinami T. Decrease in plasma cholesteryl-ester transfer protein activity with simvastatin treatment in patients with type IIa hypercholesterolemia. Curr Ther Res 1996;57:42-47.

    Google Scholar 

  26. Zhao SP, Smelt AHM, Van den Maagdenberg AMJM, et al. Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2(Arg158→Cys), E3-Leiden, and E2(Lys146→Gln), and effects of treatment with simvastatin. Arterioscler Thromb 1994;14:1705-1716.

    Google Scholar 

  27. Albers JJ, Chen CH, Adolphson JL. Lecithin:cholesterol acyltransferase (LACT) mass: Its relationship to LCAT activity and cholesterol esterification rate. J Lipid Res 1981;22:1206-1213.

    Google Scholar 

  28. Dietschy JM, Turley SD, Spady DK. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans-Review. J Lipid Res 1993;34:1637-1659.

    Google Scholar 

  29. Kovanen PT, Brown MS, Basu SK, Bilheimer DW, Goldstein JL. Saturation and suppression of hepatic lipoprotein receptors: A mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proc Natl Acad Sci USA 1981;78:1396–1400.

    Google Scholar 

  30. Kovanen PT, Bilheimer DW, Goldstein JL, Jaramillo JJ, Brown MS. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc Natl Acad Sci USA 1981;78:1194-1198.

    Google Scholar 

  31. O'Meara NMG, Devery RAM, Owens D, Collins PB, Johnson AH, Tomkin GH. Serum lipoproteins and cholesterol metabolism in 2 hypercholesterolaemic rabbit models. Diabetologica 1991;34:139-143.

    Google Scholar 

  32. Groener JEM, Van Gent T, Van Tol A. Effect of lipid transfer protein on plasma lipid, apolipoproteins and metabolism of high-density lipoprotein cholesteryl ester in the rat. Biochim Biophys Acta 1989;1002:93-100.

    Google Scholar 

  33. Jiang XC, Masucci-Magoulis L, Mar J, et al. Down-regulation of messenger RNA for the low density lipoprotein receptor in transgenic mice containing the gene for human cholesteryl ester transfer protein-Mechanism to explain accumulation of lipoprotein-B particles. J Biol Chem 1993; 268:27406-27412.

    Google Scholar 

  34. Masucci-Magoulas L, Plump A, Jiang XC, Walsh A, Breslow JL, Tall AR. Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice-A novel mechanism signals changes in plasma cholesterol levels. J Clin Invest 1996;97:154-161.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory Animal Science, University of Utrecht, Utrecht

    G.W. Meijer & A.C. Beynen

  2. Department of Biochemistry, Cardiovascular Research Institute (COEUR), Erasmus University Rotterdam, Rotterdam, The Netherlands

    J.E.M. Groener & A. Van Tol

Authors
  1. G.W. Meijer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J.E.M. Groener
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A.C. Beynen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Van Tol
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meijer, G., Groener, J., Beynen, A. et al. Lowering of Serum Cholesteryl Ester Transfer Protein—But Not Lecithin:Cholesterol Acyltransferase—Activity Levels by Hypocholesterolemic Drugs in the Rabbit. Cardiovasc Drugs Ther 12, 13–18 (1998). https://doi.org/10.1023/A:1007773011736

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1007773011736

Keywords

Search

Navigation