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Myocardioprotective Effects of Felodipine in an Antihypertensive Dosage: An Experimental Study in Pigs

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References

  1. Kloner R, Przyklenl K. Experimental infarct size reduction with calcium channel blockers. J Am Coll Cardiol 1991;18:876-878.

    Google Scholar 

  2. Haga Y, Hatori N, Nordlander M, SjÖquist P-O, Rydén L. Coronary venous retroperfusion of felodipine reducing infarct size without affecting regional myocardial blood flow. Eur Heart J 1993;14:1386-1393.

    Google Scholar 

  3. Hohlfeld T, Braun M, Strobach H, SchrÖr K. Protection of reperfused ischemic pig myocardium by nexopamil, a new combined Ca2+ and serotonin antagonist. J Cardiovasc Pharmacol 1994;23:922-931.

    Google Scholar 

  4. Walker L, Mackenzie A, Adgey J. Effect of nifedipine on enzymatically estimated infarct size in the early phase of acute myocardial infarction. Br Heart J 1988; 39:403-410.

    Google Scholar 

  5. The Israeli SPRINT Study Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial in patients with acute myocardial infarction. Eur Heart J 1988;9:354-364.

    Google Scholar 

  6. Multicenter Diltiazem Postinfarction Trial Research Group. The effect of diltiazem on mortality and reinfarction after myocardial infarction. N Engl J Med 1988;319:385-392.

    Google Scholar 

  7. The Danish Study Group on Verapamil in Myocardial Infarction. Effect of verapamil on mortality and major events after acute myocardial infarction (The Danish Verapamil Infarction Trial II-DAVIT II). Am J Cardiol 1990;66: 779-785.

    Google Scholar 

  8. Held PH, Yusuf S. Effects of yblockers and calcium channel blockers in acute myocardial infarction. Eur Heart J 1993; 14(Suppl. F):18-25.

    Google Scholar 

  9. O'Mailia K, Kelly J, O'Brien E. Clinical benefits of structural and functional changes with calcium antagonists. Am Heart J 1991;122:370-374.

    Google Scholar 

  10. Packer M. Calcium channel blockers in chronic heart failure: The risk of “physiologically rational” therapy. Circulation 1990;82:2254-2257.

    Google Scholar 

  11. Heusch G. Ischemia-selectivity: A new concept of cardioprotection by calcium antagonists. Basic Res Cardiol 1994;89: 2-5.

    Google Scholar 

  12. Ljung B. Vascular selectivity of felodipine: Experimental pharmacology. J Cardiovasc Pharmacol 1990;15(Suppl. 4): S11-S16.

    Google Scholar 

  13. Thoren P, SjÖlander M, Nordlander M. Hemodynamic effects of calcium antagonists with high and low vascular selectivity. J Cardiovasc Pharmacol 1990;15(Suppl. 4): S21-S24.

    Google Scholar 

  14. Haga Y, Uriuda Y, BjÖrkman J-A, et al. Ischemic and nonischemic tissue concentration of felodipine after coronary venous retroinfusion during myocardial ischemia and reperfusion: An experimental study in pig. J Cardiovasc Pharmacol 1994;24:298-302.

    Google Scholar 

  15. Ahnoff M. Determination of felodipine in plasma by gas chromatography with election capture detection. J Pharm Biomed Anal 1984; 52: 431-434.

    Google Scholar 

  16. Fishbein MC, Meerbaum S, Rit J. Early phase acute myocardial infarct size quantification. Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J 1981;101:593-600.

    Google Scholar 

  17. Inou T, Lamberth WC Jr., Koyanagi S, Harrison DG, Eastham CL, Marcus ML. Relative importance of hypertension after coronary occlusion in chronic hypertensive dogs with LVH. Am J Physiol 1987;253:H1148-H1158.

    Google Scholar 

  18. Dellsperger KC, Clothier JL, Koyanagi S, Inou T, Marcus ML. Effects of coronary artery occlusion in animals with hypertension and left ventricular hypertrophy. J Cardiovasc Pharmacol 1991;17(Suppl. 2): 40-45.

    Google Scholar 

  19. Hammerman H, Kloner RA, Alker KJ, Schoen FJ, Braunwald E. Effects of transient increased afterload during experimentally induced acute myocardial infarction in dogs. Am J Cardiol 1985;55:566-570.

    Google Scholar 

  20. Dellsperger KC, Martins JB, Clothier JL, Marcus ML. Incidence of sudden cardiac death associated with coronary artery occlusion in dogs with hypertension and left ventricular hypertrophy is reduced by chronic beta-adrenergic blockade. Circulation 1990;82:941-950.

    Google Scholar 

  21. Dunselman PHJM, Edgar B. Felodipine clinical pharmacokinetics. Clin Pharmacokinet 1991;21:418-430.

    Google Scholar 

  22. Franciosa JA, Limas CJ, Guiha NH, Roderiguera ER, Cohn JN. Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet 1972;1: 650-654.

    Google Scholar 

  23. Johnsson G, Murry G, Tweddel A, Hutton I. Haemodynamic effects of a new vasodilator drug, felodipine, in healthy subjects. Eur J Clin Pharmacol 1983;24:49-53.

    Google Scholar 

  24. Timmis AD, Campbell S, Monaghan MJ, Walker L, Jewitt DE. Acute haemodynamic and metabolic effects of felodipine in congestive heart failure. Br Heart J 1984;51:445-451.

    Google Scholar 

  25. SjÖquist P-O, Duker G, Almgren O. Distribution of the collateral blood flow at the lateral border of the ischemic myocardium after acute coronary occlusion in the pig and the dog. Basic Res Cardiol 1984;79:164-175.

    Google Scholar 

  26. Hearse DJ, Muller CA, Fukanami M, Kudoh Y, Opie LH, Yellon DM. Regional myocardial ischemia: Characterization of temporal, transmural and lateral flow interfaces in the porcine heart. Can J Cardiol 1986;2:48-61.

    Google Scholar 

  27. Opie LH. Should calcium antagonists be used after myocardial infarction? Ischemia selectivity versus vascular selectivity. Cardiovasc Drugs Ther 1992;6:19-24.

    Google Scholar 

  28. Bean BP. Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state. Proc Natl Acad Sci 1984;81:6388-6392.

    Google Scholar 

  29. Godfrain T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986;38:321-416.

    Google Scholar 

  30. Sanguinetti MC, Kass RS. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ Res 1984;55:336-348.

    Google Scholar 

  31. Nayer WG, Ferrari R, Williams A. Protective effect of pretreatment with verapamil, nifedipine and propranolol on mitochondrial function in the ischemic and reperfusion myocardium. Am J Cardiol 1980;46:242-248.

    Google Scholar 

  32. De Jong JW, Harmsen E, De Tombe PP. Diltiazem administered before or during myocardial ischemia decreases adenine nucleotide catabolism. J Mol Cell Cardiol 1984;16: 363-370.

    Google Scholar 

  33. Taylor AL, Golino P, Eckels R, Pastor P, Buja LM, Willerson JT. Differential enhancement of postischemic segmental systolic thickening by diltiazem. J Am Coll Cardiol 1990;15: 737-747.

    Google Scholar 

  34. Janero DR, Burghardt B. Antioxidant effects of dihydropyridine calcium antagonists. Biochem Pharmacol 1989; 38:4344-438.

    Google Scholar 

  35. Chintala MS, Jacinto S, Jandhyala BS. Studies on the deleterious effects of free radicals on myocardial contractility and hemodynamics in dogs: Protection by felodipine, a dihydropyridine calcium antagonist. Drug Dev Res 1992;27: 287-295.

    Google Scholar 

  36. Sullivan AT, Baker DJ, Drew GM. Effect of calcium channel blocking agents on infarct size after ischemic-reperfusion in anaesthetised swine: Relationship between cardioprotection and cardiodepression. J Cardiovasc Pharmacol 1991;17: 707-717.

    Google Scholar 

  37. Paulus WJ, Vantrimpont PJ, Shah AM. Acute effect of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by coronary sodium nitroprusside infusion. Circulation 1994;89:2070-2078.

    Google Scholar 

  38. Masini E, Bianchi S, Mugnai L, Gambassi F, Lupini M, Pistelli A, Mannaioni PF. The effect of nitric oxide generators on ischemic reperfusion injury and histamine release in isolated perfusion guinea-pig heart. Agents Actions 1991; 33:53-56.

    Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Karolinksa Hospital, Stockholm, Sweden

    Masafumi Shimizu, Qing-Dong Wang, Per-Ove Sjöquist, Rolf Nordlander & Lars Rydén

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  1. Masafumi Shimizu
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  2. Qing-Dong Wang
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  3. Per-Ove Sjöquist
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  4. Rolf Nordlander
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  5. Lars Rydén
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Shimizu, M., Wang, QD., Sjöquist, PO. et al. Myocardioprotective Effects of Felodipine in an Antihypertensive Dosage: An Experimental Study in Pigs. Cardiovasc Drugs Ther 12, 37–45 (1998). https://doi.org/10.1023/A:1007733313553

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