Abstract
Rainbow trout (Oncorhynchus mykiss) eggs and alevins were exposed for up to 4 weeks to the nitricoxide (NO) donor isosorbide dinitrate (ISDN) at concentrations up to 100 μmol l−1. Hatching success was over 95%, but increasing concentrations of ISDN significantly delayed hatching, without significant affects on survival. Alevins exposed to ISDN concentrations of 50 or 100 μmol l−1 showed significant cardiovascular and developmental changes compared to unexposed alevins. These included lowered heart rate and ventilation rate, doubling of cardiac output, dilation of the vitelline vein and increased in alevin weight. The results indicate a vasodilatory role of NO in trout alevins, and their cardiovascular responses to NO, with reference to the role of the vitelline vein, are discussed.
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Eddy, F., McGovern, L. & McGeer, J. Effect of a nitric oxide releasing compound isosorbide dinitrate on development and cardiovascular physiology of rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry 21, 167–171 (1999). https://doi.org/10.1023/A:1007712622522
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DOI: https://doi.org/10.1023/A:1007712622522