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The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies

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Abstract

NFκB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-α) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.

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Authors and Affiliations

  1. Laboratoire de Biochimie et Biologie Cellulaire, FUNDP, Namur, Belgium

    P. Renard & M. Raes

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  1. P. Renard
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  2. M. Raes
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Renard, P., Raes, M. The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies. Cell Biol Toxicol 15, 341–344 (1999). https://doi.org/10.1023/A:1007652414175

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