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Osteoporosis and years since menopause

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Abstract

In Fukuoka Prefecture, in south-western Japan, a regional screening program for osteoporosis was conducted from 1994 to 1995. The screening level in the bone mineral density (BMD) at the distal non-dominant radius was equal to or less than two standard deviations below age-specific mean (≤ −2.0 SD). In 1177 examinees with natural menopause (mean age: 61.4, range: 42–88), 56 of those who were screened were subsequently radiologically confirmed by orthopedic specialists to have osteoporosis (case group). They were then compared with 802 normal BMD (≥ −1.0 SD) women (reference group) with their lifestyle and reproductive characteristics. The adjusted odds ratio (OR) and its 95% confidence interval (CI) were calculated using a logistic regression model. A significant increase in the ORs for osteoporosis based on the number of years since menopause was observed for 7–13 years since menopause (OR=2.3; 95% CI: 1.0–5.4) compared with <7 years, however, no increasing trend in risk was evident in 14+ years since menopause (OR=1.4; 95% CI: 0.4–5.1). Thus, the elevated risk continued up to around 10 years since menopause. These findings are consistent with previous studies that reported an alternation in the calcium metabolism and bone loss related to the length of time after menopause. Both the childhood and current milk consumption were also associated with a decreased risk: ORs were 0.4 (95% CI: 0.2–0.9) and 0.5 (95% CI: 0.3–1.0), respectively.

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References

  1. Cummings SR, Kelsey JL, Nevitt MC, et al. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985; 7: 178–208.

    Google Scholar 

  2. Dawson-Hughes B, Krall EA, Harris S. Risk factors for bone loss in healthy postmenopausal women. Osteoporosis Int 1993; S1: 27–31.

    Google Scholar 

  3. Sowers M. Epidemiology of calcium and vitamin D in bone loss. J Nutr 1993; 123: 413–417.

    Google Scholar 

  4. Nuti R, Martini G. Effect of age and menopause on bone density of entire skeleton in healthy and osteoporotic women. Osteoporosis Int 1993; 3: 59–65.

    Google Scholar 

  5. Kajita E, Iki M, Nishino H, et al. Bone mineral density of the lumbar spine and its relation to biological and lifestyle factors in middle-aged and aged Japanese women (part 1). Relation of age and menopause to bone mineral density of the lumbar spine measured by dual-energy X-ray absorptiometry. Jpn J Hyg 1994; 49: 674–683 (In Japanese with English abstract).

    Google Scholar 

  6. Pouillès JM, Trémollières F, Bonneu M, et al. Influence of early age at menopause on vertebra bone mass. J Bone Miner Res 1994; 9: 311–315.

    Google Scholar 

  7. Kritz-Silverstein D, Barrett-Connor E. Early menopause, number of reproductive years, and bone mineral density in postmenopausal women. Am J Public Health 1993; 83: 983–988.

    Google Scholar 

  8. Bagur AC, Mautalen CA. Risk for developing osteoporosis in untreated premature menopause. Calcif Tissue In 1992; 51: 4–7.

    Google Scholar 

  9. Nordin BEC, Polley KJ. Metabolic consequences of the menopause. Calcif Tissue Int 1987; 41: S1–S59.

    Google Scholar 

  10. Nordin BEC, Need AG, Chatterton BE, et al. The relative contribution of age and years since menopause to postmenopausal bone loss. J Clin Endocrinol Metab 1990; 70: 83–88.

    Google Scholar 

  11. Ravn P, Hetland ML, Overgaard K, et al. Premenopausal and postmenopausal changes in bone mineral density of the proximal femur measured by dual-energy X-ray absorptiometry. J Bone Miner Res 1994; 9: 1975–1980.

    Google Scholar 

  12. Hansen MA, Overgaard K, Christiansen C. Spontaneous postmenopausal bone loss in different skeletal areas followed up for 15 years. J Bone Miner Res 1995; 10: 205–210.

    Google Scholar 

  13. Law MR, Wald NJ, Meade TW. Strategies for prevention of osteoporosis and hip fracture H. Br Med J 1991; 303: 453–459.

    Google Scholar 

  14. Ministry of Health and Welfare, Japan. Screening manual for osteoporosis. Tokyo: Nippon-Iji-Shinposha, 1995 (In Japanese).

    Google Scholar 

  15. Orimo H, Sugioka Y, Fukunaga M, et al. Diagnostic criteria of primary osteoporosis. J Bone Miner Metab 1998; 16: 139–150.

    Google Scholar 

  16. SAS Institute Inc. SAS/STAT User's Guide (ed. 6.03), Cary: SAS Institute Inc., 1988.

    Google Scholar 

  17. Harrell FE Jr. The LOGIST procedure. In: Joyner SP (ed), SUGI supplemental library user's guide. Cary, North Carolina: SAS Institute, 1983: 181–202.

    Google Scholar 

  18. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J 1996; 312: 1254–1259.

    Google Scholar 

  19. Kanis JA, WHO study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report. Osteoporosis Int 1994; 4: 368–381.

    Google Scholar 

  20. Nguyen TV, Jones G, Sambrook PN, et al. Effect of estrogen exposure and reproductive factors on bone mineral density and osteoporotic fracture. J Clin Endocrinol Metab 1995; 80: 2709–2714.

    Google Scholar 

  21. Marcus R, Greendale G, Blunt BA, et al. Correlation of bone mineral density in the post menopausal estrogen/progestin interventions trial. J Bone Miner Res 1994; 9: 1467–1476.

    Google Scholar 

  22. Ohta H, Masuda A, Komukai S, et al. Osteoporosis after menopause and oophorectomy. Nippon Rinsho 1994; 52: 2382–2394 (In Japanese with English abstract).

    Google Scholar 

  23. Nishino H, Tanaka T, Dohi Y, et al. Bone mineral density of the lumbar spine and its relation to biological and lifestyle factors in middle-aged and aged Japanese women (part 2). Effects of age and menopause to bone mineral density evaluated by biochemical markers of bone metabolism. Jpn J Hyg 1994; 49: 674–683 (In Japanese with English abstract).

    Google Scholar 

  24. Fleming KH, Heimbach JT. Consumption of calcium in the U.S.: Food sources and intake levels. J Nutr 1994; 124: 1426S-1430S.

    Google Scholar 

  25. Barrett-Connor E, Chang JC, Edelstein SL. Coffee associated osteoporosis offset by daily milk consumption. JAMA 1994; 271: 280–283.

    Google Scholar 

  26. Kreiger N, Gross A, Hunter G. Dietary factors and fracture in postmenopausal women: A case-control study. Int J Epidemiol 1992; 21: 953–958.

    Google Scholar 

  27. Dawson-Hughes B, Dallal GE, Krall EA, et al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 1990; 323: 878–883.

    Google Scholar 

  28. Holbrook TL, Barrett-Connor E, Wingard DL. Dietary calcium and risk of hip fracture: 14–year prospective population study. Lancet 1988; 1: 1046–1049.

    Google Scholar 

  29. Ezawa I. A dietical and nutritional therapy. Nippon Rinsho 1994; 52: 2355–2359 (In Japanese with English abstract).

    Google Scholar 

  30. Ross PD, Norimatsu H, Davis JW, et al. A comparison of hip fracture incidence among native Japanese, Japanese Americans, and American Caucasians. Am J Epidemiol 1991; 133: 801–809.

    Google Scholar 

  31. National nutrition survey. Tokyo: Health Service Bureau, Ministry of Health & Welfare, Japan, 1993.

  32. Kagawa A. Standard tables of food composition in Japan. Tokyo: Kagawa Nutrition University Press, 1995 (In Japanese).

    Google Scholar 

  33. Honjo H, Aso T, Urabe S, et al. HRT in Japan. Acta Obstet Gynaecol Jpn 1998; 50: 905–906 (In Japanese).

    Google Scholar 

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Authors and Affiliations

  1. Department of Public Health, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    Saburo Ide & Yoshio Hirota

  2. Department of Orthopedic Surgery, Faculty of Medicine, Saga Medical School, Saga, Japan

    Takao Hotokebuchi

  3. Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    Shin-ichiro Takasugi & Yoichi Sugioka

  4. Faculty of Human Environmental Science, Fukuoka Women's University, Fukuoka, Japan

    Hitomi Hayabuchi

  5. Faculty of Nursing, St. Mary's College, Kurume, Fukuoka, Japan

    Saburo Ide

Authors
  1. Saburo Ide
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  2. Yoshio Hirota
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  3. Takao Hotokebuchi
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  4. Shin-ichiro Takasugi
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  5. Yoichi Sugioka
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  6. Hitomi Hayabuchi
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Ide, S., Hirota, Y., Hotokebuchi, T. et al. Osteoporosis and years since menopause. Eur J Epidemiol 15, 739–745 (1999). https://doi.org/10.1023/A:1007611412532

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  • DOI: https://doi.org/10.1023/A:1007611412532

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