Abstract
Creutzfeldt–Jakob disease (CJD) is the most important human transmissible spongiform encephalopathy (prion disease), recognised in sporadic, genetic but also iatrogenic forms. The identification of 8 health care workers in a group of 114 definitive CJD patients in Slovakia suggested the possibility of professionaly acquired CJD and induced the investigation of potential endo- and exogenous risk factors. In CJD-affected health professionals special attention was paid to a detailed occupational history, including a possible professional contact with CJD patient and to the findings characteristic for iatrogenic CJD: early cerebellar symptomatology, long duration of the disease, absence of typical EEG finding and homozygosity of PRNP gene at codon 129. Analysis of epidemiological, clinical and molecular biological data in investigated group of CJD-affected health professionals gave no evidence of an occupational risk for CJD.
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References
Mitrová E, Broniš M. “Clusters” of CJD in Slovakia: The first statistically significant temporo-spatial accumulations of rural cases. Europ J Epid 1991; 7: 450–456.
Goldfarb LG, Mitrová E, Brown P, et al. Mutation in codon 200 of scrapie amyloid protein gene in two clusters of CJD in Slovakia. Lancet 1990; 336: 514–515.
Goldfarb L, Brown P, Mitrová E, et al. CJD associated with the PRNP codon 200Lys mutation: an analysis of 45 families. Europ J Epid 1991; 7: 477–486.
Meiner Z, Gabizon R, Prusiner S. Familial CJD: codon 200 prion disease. Libyan Jews Medicine 1997; 76: 227–237.
Mitrová E. Some new aspects of CJD epidemiology in Slovakia. Europ J Epid 1991; 7: 439–450.
Koch TK, Berg BO, DeArmond SJ, et al. Creutzfeldt-Jakob Disease in a young adult with idiopathic hypopituitarism. N Eng J Med 1985; 313: 731–733.
Brown P, Cervenáková L, Goldfarb LG, et al. Iatro-genic Creutzfeldt-Jakob Disease: An example of the interplay between ancient genes and modern medicine. Neurology 1994; 44: 291–293.
Zeidler M, Stewart GE, Barraclough CR, et al. New variant CJD: Neurological features and diagnostic tests. Lancet 1997; 350: 903–907.
Berger JR, David NJ. Creutzfeldt-Jakob Disease in a physician: A review of the disorder in health care workers. Neurology 1993; 43: 205–206.
Van Duijn CM, Delasniere-Laupetre N, Massulo C, et al. Case-control study of risk factors of CJD in Europe during 1993–95. Lancet 1998; 351: 1081–1085.
Krajícková D, Foukal T, Schreiber M, Creutzfeldt-Jakob Disease in a nurse. Praktick lékar 1997; 6: 282–283.
Wientjens DPWM, Davanipour Z, Hofman A, et al. Risk factor for Creutzfeldt-Jakob disease: A re-analysis of case-control studies. Neurology 1996; 46: 1287–1291.
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Mitrová, E., Belay, G. Creutzfeldt–Jakob Disease in health professionals in Slovakia. Eur J Epidemiol 16, 353–355 (2000). https://doi.org/10.1023/A:1007601313133
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DOI: https://doi.org/10.1023/A:1007601313133