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IDPN-Induced Monoamine and Hydroxyl Radical Changes in the Rat Brain

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Abstract

β-β′-iminodipropionitrile (IDPN)-induced monoamine and hydroxyl radical changes in the rat brains were studied. IDPN caused decreases in 5-HT and 5-HIAA levels in all brain regions, strongly indicating that IDPN's neurotoxicity primarily affects 5-HT containing neurons. Dopamine and its metabolites' levels decreased in the some regions, most likely due to depression of dopamine metabolic turnover. Our results more clearly demonstrate IDPN-induced monoamine alterations in the rat brain more than previous reports. To clarify one of the pathogenesis of IDPN-induced neurological disorders, we measured hydroxyl radical levels. 2,3-DHBA increased at 1st day, and decreased in some regions at 7th days after discontinuing IDPN. We conclude, hydroxyl radical formation causes neuronal damage, and monoamine changes contribute to IDPN-induced neurological disorder.

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Authors and Affiliations

  1. Fourth Department of Internal Medicine, Toho University, 2-17-6 Oohashi, Meguro-ku, Tokyo, 153-8515, Japan

    Nobuo Wakata, Yoho Araki, Hideki Sugimoto, Hiroaki Iguchi & Masao Kinoshita

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  1. Nobuo Wakata
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  2. Yoho Araki
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  3. Hideki Sugimoto
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  4. Hiroaki Iguchi
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  5. Masao Kinoshita
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Wakata, N., Araki, Y., Sugimoto, H. et al. IDPN-Induced Monoamine and Hydroxyl Radical Changes in the Rat Brain. Neurochem Res 25, 401–404 (2000). https://doi.org/10.1023/A:1007553323461

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  • DOI: https://doi.org/10.1023/A:1007553323461

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