Abstract
The purpose of the present study was to investigate the antibiotics utilization in the University Hospital Center of Rijeka (UHC), with capacity of 1566 beds, during the period of 4 years (1990–1994). The data concerning the antibiotics utilization were collected from a hospital pharmacy record and calculated as the defined daily dose (DDD) per 100 bed days. Total antibiotics use decreased continually from 1990 through 1994. According to our study, metronidazole became the most frequently prescribed antibiotic. Comparing the 1994 to the 1990 antibiotics utilization, we may notice an outstanding decrease in cotimoxazole, ampicillin and cefalexin utilization and an increase in amoxicillin + clavulanic acid, gentamycin and cefuroxime (there are no tetracyclines among the 10 most frequently prescribed antibiotics). The changes noticed in the use of antibiotics are partly caused by changes in therapeutic principles, but we consider drug notations as the most important factor. Drug donations have retained the treatment quality of our patients in very difficult conditions in Croatia during the war period.
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References
Smith AJ, Aronson JK, Thomas M. Antibiotics policies in the developing world. Eur J Clin Pharmacol 1991; 41: 85–87.
Periti P. Pharmacoeconomic evaluation of once-daily aminoglycoside treatment. J Chemother 1995; 7: 380–394.
Roder BL, Nielsen SL, Magnussen P, et al. Antimicrobial practise. Antibiotic usage in an intensive care unit in a Danish university hospital. J Antimicrob Chemother 1993; 32: 633–642.
Moss F, McNicol MW, McSwiggan DA, Miller DL. Survey of antibiotic prescribing in a district general hospital. I. Pattern of use. Lancet 1981; ii: 349–352.
Misan GMH, Martin ED, Smith ER, Somogyi AA, Bartholomeusz RAC, Bochner F. Drug utilization review in a teaching hospital: Experience with vancomycin. Eur J Clin Pharmacol 1990; 39: 457–461.
Stobberingh E, Jauhnegt R, Wijnands G. Antibiotic guidelines and antibiotic utilization in Dutch hospitals. J Antimicrob Chemother 1993; 32: 153–161.
Radošjević Z, Krstić Burić M. Tuberkuloza u Hrvatskoj. Medicus 1994; 3: 37–61.
Atanasova I, Terziivanov D. Investigation on antibiotics in a hospital for a one year period. Int J Clin Pharmacol Therap 1995; 33: 32–33.
Halls GA. Antimicrobial practise. The management of infections and antibiotic therapy. A European survey. J Antimicrob Chemother 1993; 31: 985–1000.
Shrimpton SB, Milmoe M, Wilson APR, et al. Antimicrobial practise. Audit of prescription and assay of aminoglycosides in a UK teaching hospital. J Antimicrob Chemother 1993; 31: 599–606.
Žunić J, Novosel D. Drug use in the intensive therapy unit. Pharmaca 1993; 29: 181–236.
Žunić J. The use of drugs in the emergency surgery in a war area: Medical Center Karlovac, Croatia. Pharmaca 1993; 31: 269–277.
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Vlahović Palčevski, V., Vitezić, D. & Palčevski, G. Antibiotics utilization during the war period: Influence of drug donations. Eur J Epidemiol 13, 859–862 (1997). https://doi.org/10.1023/A:1007481925241
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DOI: https://doi.org/10.1023/A:1007481925241