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European Journal of Epidemiology

, Volume 14, Issue 6, pp 621–626 | Cite as

Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil

  • Ikuko Kato
  • Joseph H. Vogelman
  • Vladimir Dilman
  • Jerzy Karkoszka
  • Krystyna Frenkel
  • Nancy P. Durr
  • Norman Orentreich
  • Paolo Toniolo
Article

Abstract

Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 μg chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96–1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.

Autoantibodies Chromium picolinate Dietary supplement DNA damage HMdU 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Ikuko Kato
    • 1
  • Joseph H. Vogelman
    • 2
  • Vladimir Dilman
    • 1
  • Jerzy Karkoszka
    • 1
  • Krystyna Frenkel
    • 1
  • Nancy P. Durr
    • 2
  • Norman Orentreich
    • 2
  • Paolo Toniolo
    • 1
  1. 1.Nelson Institute of Environmental Medicine, New York University School of MedicineNew York
  2. 2.Biomedical Research StationOrentreich Foundation for the Advancement of Science, Inc.Cold-Spring-on-HudsonUSA

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