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Lymphocytic choriomeningitis virus in southern France: Four case reports and a review of the literature

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Abstract

Infections due to choriomeningitis virus have been only infrequently reported in humans. Most cases have been diagnosed during laboratory outbreaks in the USA and Germany. In this report, we describe 4 cases of acute meningitis due to choriomeningitis virus occurring after close contact with domestic syrian hamsters. Although the disease is usually mild, some fatal cases have been described. The purpose of this report is to alert physicians to the possibility of lymphocytic choriomeningitis in patients who have had close contact with Syrian hamsters.

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References

  1. Casals, J. Arenaviruses. In: Evans AS (ed), Viral infections of humans: Epidemiology and control. New York: Plenum Medical Book Company, 1982: 127–150.

    Google Scholar 

  2. Johnson KE. Lymphocytic choriomeningitis virus, Lassa virus (Lassa fever) and other arenaviruses. In: Mandell G, Gordon Douglas R, Bennett JG (eds), Principles and practice of Infectious Diseases. New York: Churchill Livingstone, 1992: 1329–1336.

    Google Scholar 

  3. Baum S, Lewis A, Rowe W, Huebner R. Epidemic nonmeningitic lymphocytic-choriomeningitis-virus infection: An outbreak in a population of laboratory personnel. New Engl J Med 1966; 274: 934–936.

    Google Scholar 

  4. Thiede W, Milwaukee. Cardiac involvement in lymphocytic choriomeningitis. Arch Int Med 1962; 109: 50–54.

    Google Scholar 

  5. Lewis A, Rowe W, Turner H, Huebner R. Lymphocytic choriomeningitis virus in hamster tumor: Spread to hamsters and humans. Sciences 1965; 1: 363–364.

    Google Scholar 

  6. Hirsch E. Sensineural deafness and labyrinth damage due to lymphocytic choriomeningitis: Report of a case. Arch Otolaryngol 1976; 102: 499–500.

    Google Scholar 

  7. Sheinbergas MM, Lewis VJ, Thacker WL, Verikiene VV. Serological diagnosis in children infected prenatally with lymphocytic choriomeningitis virus. Infect Immun 1981; 31: 837–838.

    Google Scholar 

  8. Larsen P, Chartrand S, Tomashek K. Hydrocephalus complicating lymphocytic choriomeningitis virus infection. Ped Infect Dis 1993; 12: 528–531.

    Google Scholar 

  9. Ackermann R, Körver G, Tirss R, Wönne R, Hochgesand P. Pränatale infektion mit dem Virus der lymphozytären Choriomeningitis. Dtsch Med Wschr 1974; 99: 629–632.

    Google Scholar 

  10. Hirsch M, Moellering R, Pope H, Poskanzer D. Lymphocytic-choriomeningitis-virus infection traced to a pet hamster. New Engl J Med 1974; 3: 610–612.

    Google Scholar 

  11. Vanzee B, Douglas R, Betts R, Bauman A, Fraser D, Hinman A. Lymphocytic choriomeningitis in university hospital personnel. Am J Med 1975; 58: 803–809.

    Google Scholar 

  12. Riviere Y, Rafi A, Southern P, Buchmeier M, Dutko F, Oldstone M. The s RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoprotein 1 and 2. J Virol 1985; 53: 966–968.

    Google Scholar 

  13. Auperin D, Romanowski V, Galinski M, Bishop D. Sequencing studies of pinchinde arenavirus s RNA indicate a novel coding strategy, an ambisense viral s RNA. J Virol 1984; 52: 897–904.

    Google Scholar 

  14. Traub E. Factors influencing the persistence of choriomeningitis virus in the blood of mice after clinical recovery. J Exp Med 1938; 68: 229–250.

    Google Scholar 

  15. Oeheren S, Waldner H, Kundig TM. Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J Exp Med 1992; 176: 1273–1281.

    Google Scholar 

  16. Welsh R, Lampert P, Oldstone M. Prevention of virus induced cerebellar diseases by defective-interferring lymphocytic choriomeningitis virus. J Infect Dis 1977; 136: 391–399.

    Google Scholar 

  17. Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogenic system. Nature 1974; 248: 701–702.

    Google Scholar 

  18. Hotchin J, Kinch W, Sikora E. Some observations on hamsters-derived human infection with lymphocytic choriomeningitis virus. Bull World Health Organ 1975; 52: 561–565.

    Google Scholar 

  19. Skinner H, Knight E, Buckley L. The hamster as a secondary reservoir host of lymphocytic choriomeningitis virus. J Hyg 1976; 76: 299.

    Google Scholar 

  20. Biggar R, Deibel R, Woodall J. Implications, monotoring, and control of accidental transmission of lymphocytic choriomeningitis virus within hamsters tumor cell lines. Cancer Res 1976; 36: 551–553.

    Google Scholar 

  21. Armstrong D, Fortner J, Rowe W, Parker J. Meningitis due to lymphocytic choriomeningitis virus endemic in a hamster colony. JAMA 1969; 209: 265–267.

    Google Scholar 

  22. Bowen G, Calisher C, Winkler W, Kraus A, Fowler E, Garman R, Fraser D, Hinman A. Laboratory study of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals. Am J Med 1975; 102: 233–240.

    Google Scholar 

  23. Gregg M. Recent outbreak of choriomeningitis in the United States of America. Bull World Health Organ 1975; 52: 549–553.

    Google Scholar 

  24. Bhatt PN, Jacoby RO, Barthold SW. Contamination of transplantable murine tumors with lymphocytic choriomeningitis virus. Lab Anim Sci 1986; 36: 136–139.

    Google Scholar 

  25. Hotchin J. The contamination of laboratory animals with lymphocytic choriomeningitis virus. Am J Pathol 1971; 64: 747–769.

    Google Scholar 

  26. Hotchin J, Sikora E, Kinch W. Lymphocytic choriomeningitis in a hamster colony causes infection of hospital personnel. Sciences 1974; 185: 1173–1174.

    Google Scholar 

  27. Hinman A, Fraser D, Douglas R, Bowen G, Kraus A, Winkler W, Rhodes W. Outbreak of lymphocytic choriomeningitis virus infections in medical center personnel. Am J Epidemiol 1975; 101: 103–110.

    Google Scholar 

  28. Biggar R, Woodall J, Walter P, Haughie G. Lymphocytic choriomeningitis outbreak associated with pet hamsters. JAMA 1975; 232: 494–500.

    Google Scholar 

  29. Biggar R, Douglas R, Hotchin J. Letter: Lymphocytic choriomeningitis associated with hamsters. Lancet 1975; 12: 856–857.

    Google Scholar 

  30. Ackermann R, Stille W, Blumenthal K. Syrische hamster als unbertrager von lymphozytärer choriomeningitis. Dtsch Med Wschr 1972; 97: 1725–1731.

    Google Scholar 

  31. Childs J, Glass G, Korch G, Ksiazek T, Leduc J. Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. Am J Trop Med Hyg 1992; 47: 27–34.

    Google Scholar 

  32. Sato H, Miyata H. Detection of lymphocytic choriomeningitis virus antibodies in colonies of laboratory animals in Japan. Jikken Dobutsu 1986; 35: 189–192.

    Google Scholar 

  33. Blumenthal W, Kessler R, Ackermann R. The infection of the rural population in the Federal Republic of Germany with the lymphocytic choriomeningitis virus. Zentral Blat Bakteriol 1970; 213: 36–48.

    Google Scholar 

  34. Chields J, Glass G, Ksiazek T, Rossi C, Barrera Oro J, Leduc J. Human-rodent contact and infection with lymphocytic choriomeningitis and seoul viruses in an inner-city population. Am J Trop Med Hyg 1991; 44: 117–121.

    Google Scholar 

  35. Gaiadamovitch S, Kocherovskaia M. Acute and chronic infection of mice, caused by lymphocytic choriomeningitis virus isolated from Mus musculus in Moscow. Vopr Virusol 1976; 2: 223–226.

    Google Scholar 

  36. El Karamany R, Imam I. Antibodies to lymphocytic choriomeningitis virus in wild rodent sera in Egypt. J Hyg Epidemiol Microbiol Immunol 1991; 35: 97–103.

    Google Scholar 

  37. Deibel R, Woodall J, Decher W, Schryver G. Lymphocytic choriomeningitis virus in man: Serologic evidence of association with pet hamsters. JAMA 1975; 232: 501–504.

    Google Scholar 

  38. Blumenthal W, Ackermann R, Kessler R. The distribution of infection with the virus of choriomeningitis among the population of the Federal German Republic. Zentral Blat Bakteriol 1970; 212: 413–415.

    Google Scholar 

  39. Scheid W, Ackermann R, Felgenhauer K. Lymphocytic choriomeningitis in the form of lethargic encephalitis. Dtsch Med Wschr 1968; 93: 940–943.

    Google Scholar 

  40. Mac Callum F, Finlay G. Lymphocytic choriomeningitis isolation from the nazopharynx. Lancet 1939; 3: 1370–1373.

    Google Scholar 

  41. Blumenthal W, Ackermann R, Scheid W. Durchseuchung mit dem Virus der lymphozytaren Choriomeningitis in einem Endemiegebiet. Dtsch Med Wschr 1968; 93: 944–948.

    Google Scholar 

  42. Lewis J, Utz J. Orchitis, parotitis and meningoencephalitis due to lymphocytic choriomeningitis virus. New Engl J Med 1961; 16: 776–780.

    Google Scholar 

  43. Warkel R, Rinaldi C, Bancroft W, Cardiff R, Holmes G, Wilsnack R. Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. Neurology 1973; 23: 198–203.

    Google Scholar 

  44. Ormay I, Kovacs P. Lymphocytic choriomeningitis causing unilateral deafness. Orv Hetil 1989; 130: 789–791.

    Google Scholar 

  45. Sheinbergas M. Hydrocephalus due to prenatal infection with lymphocytic choriomeningitis virus. Infection 1976; 4: 185–191.

    Google Scholar 

  46. Sheinbergas MM, Kilchavskiene VV, Tulevichiene JP. Prenatal lymphocytic choriomeningitis (LCM): Three new cases. Infection 1984; 12: 105–106.

    Google Scholar 

  47. Chastel C, Bosshard S, Le Goff F, Quillien M, Gilly R, Aymard M. Infection transplacentaire par le virus de la chorioméningite lymphocytaire. Nouv Presse Med 1978; 13: 1089–1091.

    Google Scholar 

  48. B.S. Niklasson, P.B.J.A.C.P. Detection of Lassa virus antigens and Lassa-specific IgG and IgM by enzyme-linked immunosorbent assay. J Clinical Microbiology 1984; 20: 239.

    Google Scholar 

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Rousseau, M., Saron, M., Brouqui, P. et al. Lymphocytic choriomeningitis virus in southern France: Four case reports and a review of the literature. Eur J Epidemiol 13, 817–823 (1997). https://doi.org/10.1023/A:1007434521082

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  • DOI: https://doi.org/10.1023/A:1007434521082

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