Abstract
The prevalence of antibodies for one or more HCV antigens was 2.3% of 1,347 mothers at childbirth. Compared with the principal factors studied, the presence of antibodies was more frequent in women who were carriers of HIV infection (3/3), in those who had suffered liver diseases (5/37) or who had had transfusion (3/25). This was as opposed to women who did not have any risk factor (p < 0.001). The prevalence of HCV-RNA was 1.3%; in relation to the antibody state, such a condition was more frequent in subjects with antibodies for 3 or 4 antigens (about 80%) compared with those who were positive for 1 or 2 antigens. HCV-RNA of the same genotype as the mother (type 1; 1a) was also found in the funicular blood of 2 of the 18 babies born to mothers who were positive for HCV-RNA. In the course of the follow-up (from the 3rd to the 18th month) the viral RNA was not found in any of the babies, nor was it found in the 2 who were positive at birth. Even the antibodies gradually disappeared, although slowly. At the 10th month, 91% of the babies resulted as having no antibodies and at the 18th month none of the babies resulted as having antibodies. Breast-feeding also appeared to have no influence on the transmission of the infection; out of 18 viremic mothers indeed 12 (67%) breast-fed their babies.
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References
Alter MJ. Transmission of hepatitis C virus: Route, dose, and titer. N Engl J Med 1994; 330: 784–786.
Thaler MM, Park CK, Landers DV, et al. Vertical transmission of hepatitis C virus. Lancet 1991; 338: 17–18.
Otho H, Terazawa S, Sasaki N, et al. Transmission of hepatitis C virus from mothers of infants. N Engl J Med 1994; 330: 744–750.
Ribero ML, Tremolada F, Chiaromonte S, et al. HCV detection in non-A, non-B patients groups. In: Polders I, Stuyck M (eds), New challenges in blood banks screening and environment, Paris, October 1992, Interface Proceeding. Turnhout (Belgium), 1993: 7–10.
Okamoto H, Tokita H, Sakamoto M, et al. Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J Gen Virol 1993; 74: 2385–2390.
Okamoto H, Sugiyama Y, Okada S, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources. J Gen Virol 1992; 73: 673–679.
Tagger A, Ribero ML, Tremolada F, et al. Hepatitis C viremia and serologic profile in post-transfusion non-A, non-B hepatitis. In: Nishioka K, Suzuki H, Mishiro S (eds), Viral hepatitis and liver disease. Tokio: Springer Verlag, 1994: 565–568.
Choo QL, Richman KH, Han JH, et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci USA 1991; 88: 2451–2455.
Pozzato G, Moretti M, Franzin F et al. Severity of liver disease with different hepatitis C viral clones. Lancet 1991; 338: 509.
Simmonds P, Holmes EC, Cha TA, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 1993; 74: 2391–2399.
Novati R, Thiers V, Monforte A, et al. Mother to child transmission of hepatitis C virus detected by nested polymerase chain reaction. J Infect Dis 1992; 165: 720–723.
Zanetti AR, Tanzi E, Paccagnini S, et al. Mother-to-infant of hepatitis C virus. Lancet 1995; 345: 289–291.
Zuccotti GV, Ribero ML, Giovannini M, et al. Effect of hepatitis C genotype on mother-to-infant transmission of virus. J Pediatr 1995; 127: 278–280.
Paccagnini S, Principi N, Massironi E, et al. Perinatal transmission and manifestation of hepatitis C virus infection in a high risk population. Pediatr Infect Dis J 1995; 14: 195–199.
Moriya T, Sasaki F, Mizui M, et al. Transmission of hepatitis C virus from mothers to infants: Its frequency and risk factors revisited. Biomed-Pharmacother 1995; 49: 59–64.
Maggiore G, Ventura A, De Giacomo C, et al. Vertical transmission of hepatitis C. Lancet 1995; 345: 1122.
Lam JPH, McOmish F, Burns SM, et al. Infrequent vertical transmission of hepatitis C virus. J Infect Dis 1993; 167: 572–576.
Giacchino R, Picciotto A, Tasso L, et al. Vertical transmission of hepatitis C. Lancet 1995; 345: 1122–1123.
Roudot-Thoraval F, Pawlotsky JM, Thiers V, et al. Lack of mother-to-infant transmission of hepatitis C virus in human immunodeficiency virus-seronegative women: A prospective study with hepatitis C virus RNA testing. Hepatology 1993; 17: 772–777.
Marcellin P, Bernuau J, Martinot PM, et al. Prevalence of hepatitis C virus infection in asymptomatic anti-HIV 1 negative pregnant women and their children. Dig Dis Sci 1993; 38: 2151–2155.
Kudesia G, Ball G, Irving WL. Vertical transmission of hepatitis C. Lancet 1995; 345: 1122.
Manzini P, Saracco G, Cerchier A, et al. Human immunodeficiency virus infection as risk factor for mother-to-child hepatitis C virus transmission: Persistence of anti-hepatitis C virus in children is associated with the mother's anti-hepatitis C virus immunoblotting pattern. Hepatology 1995; 21: 328–332.
Uehara S, Abe Y, Saito T, et al. The incidence of vertical transmission of hepatitis C virus. Tohoku J Exp Med 1993; 171: 195–202.
Gurakan B, Oran O, Yigit S. Vertical transmission of hepatitis C virus. N Engl J Med 1994; 331: 399.
Ho-Hsiung Lin, Jia-Horng Kao, Hong-Yuan Hsu, et al. Absence of infection in breast-fed infants to hepatitis C virus-infected mothers. J Pediatr 1995; 126: 589–591.
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Tanzi, M., Bellelli, E., Benaglia, G. et al. The prevalence of HCV infection in a cohort of pregnant women, the related risk factors and the possibility of vertical transmission. Eur J Epidemiol 13, 517–521 (1997). https://doi.org/10.1023/A:1007374810981
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DOI: https://doi.org/10.1023/A:1007374810981