Abstract
Long-term residents of the Philippines were skin tested with histoplasmin skin test material. This study was conducted with 143 electric company (MERALCO) employees from Manila, Philippines. We found that 37 (26 %) of the subjects were skin test positive. Characteristics of the positive group were: average age of 37 years; all except one were lifelong inhabitants of Metro Manila; 25 were male and 12 were female; one-half of the subjects reported extended contact with chickens. Despite these findings, histoplasmosis is considered to be a very rare disease in the Philippines. This survey indicates that Histoplasma capsulatum is sufficiently present in the Philippines to come in contact withone-fourth of the test population. This reinforces the hypothesis that histoplasmosis is present in the Philippines and is probably being misdiagnosed as granulomatous-inducing diseases such as tuberculosis, e.g., so-called “drug resistant” tuberculosis. We recommend larger surveys of this type and attempts to culture the etiologic agent from natural sources such as chicken and bat droppings.
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References
WHO Citation. TB still kills 132 Filipinos daily. The Philippine Star. August 20, 2000: 7.
Emmons CW. Isolation of Histoplasma capsulatum from soil. Public Health Rep. 1949; 64: 892–896.
Edwards PQ, Billings EL. Worldwide patterns of skin testing sensitivity to histoplasmosis. Am. J. Trop. Med. Hyg. 1971; 20: 288–319.
Baum CL, Wu JN, Hua SS, Baum C, Ajello L. Skin sensitivity to histolyn, spherulin and PPD in the People' Republic of China. Chest 2000; 97(6): 1356–1359.
Wen FQ, Sun YD, Watanabe K, Yoshida M, Wu JN, Baum GL. Prevalence of histoplasmin sensitivity in healthy adults and tuberculosis patients in southwest China. J. Med. Vet. Mycol. 1996; 34: 171–174.
Zhao B, Yin J, Xia X. Investigation on the epidemiology of Histoplasma capsulatum infection in Nanjing district. Chung Hua Liu Hsing Ping Hsueh Tsa Chih 1998; 19: 215–217.
Navarra STV, Mateo MO, Bulmer CS, Torralba LD, Javate R. A culturally proven case of disseminated histoplasmosis in the Philippines. Phil. J. Int. Med. 1992; 30: 69–77.
Navarro EE, Tupasi TE, Verallo VM, Romero RC, Tuazon CU. Disseminated histoplasmosis with unusual cutaneous lesions in a patient from the Philippines. Am. I. Trop. Med. Hyg. 1992; 46: 141–145.
Macher AM, De Vinatea ML, Tuur SM, Angritt P. AIDS and the mycoses. Inf. Dis. Clinics of N. A. 1998; 2: 827–839.
Hamilton AJ. Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends 4. Med. Mycol. 1998; 36: 351–364.
Kaufman L, Standard PG, Anderson SA, Jalbert M, Swisher BL. Development of specific fluorescent-antibody test for tissue form of Penicillium marneffei. J Clin Microbiol 1995; 33: 2136–2138.
Scalarone GM, Restrepo A, Schacht LR, Rupp GH, LeRoy MD. Lack of antibody induction by Histolyn-CYL, a new skin testing reagent for histoplasmosis. Sabouraudia 1985; 23: 335–338.
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Bulmer, A.C., Bulmer, G.S. Incidence of histoplasmin hypersensitivity in the Philippines. Mycopathologia 149, 69–71 (2001). https://doi.org/10.1023/A:1007277602576
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DOI: https://doi.org/10.1023/A:1007277602576