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Evaluation of Biochemical Markers of Bone Metabolism in Patients with Secondary Hyperparathyroidism

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Abstract

We studied the biochemical markers of bone metabolism and bone mineral density (BMD) in 43 male haemodialysis patients. We measured serum levels of carboxyterminal parathyroid hormone (PTH-c), carboxyterminal propeptide of human type I procollagen, calcitonin, intact osteocalcin, cross-linked carboxyterminal telopeptide of human type I collagen, and alkaline phosphatase. We divided all patients into 2 groups (group A and B), those with serum PTH-c levels of 7.5 ng/ml or higher, and those with levels lower than 7.5 ng/ml, respectively. In group A, the levels of markers for bone formation and for bone resorption were notably elevated, while BMD was not significantly decreased. The level of serum markers for bone metabolism appears to be more sensitive than BMD for the clinical assessment of secondary hyperparathyroidism.

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Authors and Affiliations

  1. Haemodialysis Center, Ikeda Hospital, Ohzu-city, Ehime, Japan

    M. Matsui, T. Teraoka & M. Ikeda

  2. Department of Urology, Ehime University Medical School, Onsen-gun, Ehime, Japan

    N. Tanji & M. Yokoyama

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  1. M. Matsui
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  2. N. Tanji
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  3. T. Teraoka
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  4. M. Yokoyama
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  5. M. Ikeda
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Matsui, M., Tanji, N., Teraoka, T. et al. Evaluation of Biochemical Markers of Bone Metabolism in Patients with Secondary Hyperparathyroidism. Int Urol Nephrol 31, 737–741 (1999). https://doi.org/10.1023/A:1007185227485

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  • DOI: https://doi.org/10.1023/A:1007185227485

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