Abstract
To investigate the relationship between localization of hepatocyte growth factor (HGF) and tubulointerstitial lesions (TILs) in the cortical area of renal biopsy specimens, a clinicopathological study was performed in 55 patients with IgA nephropathy. HGF was detected by an enzyme-antibody method and TILs were assessed semiquantitatively by light microscopy. HGF was observed mainly on epithelial cells in the tubules, but not in the glomeruli. Fourteen patients had biopsies that were positive for HGF. There was a correlation between HGF positivity and histological damage, the TIL grade, and several clinical parameters determined at biopsy. Thus, HGF is related to TILs in IgA nephropathy and may be a factor in the exacerbation of this disease.
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Neimark, A., Fidirkin, A., Celovalnikova, I.: Enzymuria as early marker of interstitial nephritis. Int. Urol. Nephrol., 29(2), 137 (1997).
Bohle, A., Mackensen-Haen, S., Gise, H.: Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney. Am. J. Nephrol., 7, 421 (1987).
Knan, T. N., Sinniah, R.: Morphometric study showing the importance of distal tubular damage in impaired creatinine clearance. Am. J. Nephrol., 13, 178 (1993).
Burton, C. J., Walls, J.: Proximal tubular cell, proteinuria and tubulointerstitial scarring. Nephron., 68, 287 (1994).
Vanderlinde, R. E.: Urinary enzyme measurements in the diagnosis of renal disorders. Ann. Clin. Lab. Sci., 11, 189 (1991).
Kanahara, K., Yorioka, N., Ogawa, T., Taniguchi, Y., Takemasa, A., Hirabayashi, A., Yamakido, M.: An immunohistochemical study of extracellular matrix components and integrins in human glomerular diseases. Jpn. J. Nephrol., 36, 355 (1994).
Kanahara, K., Yorioka, N., Arita, M., Ohira, N., Yamakido, M.: Immunohistochemical studies of extracellular matrix components and integrins in IgA nephropathy. Nephron, 66, 29 (1994).
Abe, S., Amagasaki, Y., Iyori, S., Konishi, I., Kato, E., Sakaguchi, H.: Significance of tubulointerstitial lesions in biopsy specimens of glomerulonephritic patients. Am. J. Nephrol., 9, 30 (1989).
Wang, H., Tomino, Y., Fukui, M., Shirato, I., Yaguchi, Y., Ebihara, I., Kubota, M., Nakayama, S., Koide, H.: Correlation between tubulointerstitial changes and prognosis in patients with primary membranous nephropathy. Nephron, 67, 362 (1994).
Eknoyan, G., McDonald, M.A., Appel, D., Truong, L.D. Chronic tubulointerstitial nephritis: Correlation between structural and functional findings. Kidney Int., 38, 736 (1990).
Weidner, K.M., Arakaki, N., Hartmann, G., Vandekerckhove, J., Weingart, S., Rieder, H.: Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl. Acad. Sci. USA., 88, 7001 (1991).
Fine, L.: The biology of renal hypertrophy. Kidney Int., 29, 619 (1986).
Kenny, A. J., O'Hare, M. J., Gusterson, B. A.: Cell-surface peptidases as modulators of growth and differentiation. Lancet, II, 785 (1989).
Weinberg, J. M.: The cell biology of ischaemic renal injury. Kidney Int., 39, 476 (1991).
Wolf, G., Neilson, E. G.: Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int., 39, 401 (1991).
Verstrepen, W. A., Nouwen, E. J., Yue, X. S., De Broe, M. E.: Altered growth factor expression during toxic proximal tubular necrosis and regeneration. Kidney Int., 43, 1267 (1993).
Nagaike, M., Hirao, S., Tajima H., Noji S., Taniguchi, S., Matsumoto, K., Nakamura, T.: Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy. J. Biol. Chem., 266, 22781 (1991).
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Fidirkin, A., Neimark, A., Nepomnyashchikh, D. et al. Tubulointerstitial Lesions in IgA Nephropathy and Localization of Hepatocyte Growth Factor. Int Urol Nephrol 31, 557–562 (1999). https://doi.org/10.1023/A:1007183832512
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DOI: https://doi.org/10.1023/A:1007183832512