Mycopathologia

, Volume 148, Issue 2, pp 79–82 | Cite as

Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis

  • Depo Yang
  • Laura Michel
  • Jean-Pierre Chaumont
  • Joëlle Millet-Clerc
Article

Abstract

Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen because of their very different chemical structures. So, a new model has been tested, utilizing sheep hoof plates in order to simulate human nails, which are almost unobtainable for in vitro tests. Three protocols were utilized: pre-treatment. simultaneous treatment and post-treatment. Among these, the post-treatment method was the best to simulate antifungal therapy. as it permitted testing and comparing the efficiency of different antifungal drugs.

Antifungal caryophyllene oxide onychomycosis model sheep hoof plate 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Depo Yang
    • 1
  • Laura Michel
    • 1
  • Jean-Pierre Chaumont
    • 2
  • Joëlle Millet-Clerc
    • 1
  1. 1.Laboratoire de Pharmacic GaléniqueFaculté de Médecine et de Pharmacie, Place Saint-JacquesBesançon CedexFrance
  2. 2.Laboratoire de Botanique et CryptogamieFaculté de Médecine et de Pharmacie, Place Saint-JacquesBesançon CedexFrance

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