Abstract
Activities of arginase, prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) were determined in sera of healthy male controls, benign prostatic hypertrophy (BPH) and prostatic cancer patients. Serum arginase activity in the cancer group (22.8±11.6 U/l) was significantly lower than in both the control (33.64±16.19 U/l) and the BPH group (58.8±11.6 U/l) (p<0.001, respectively), while the BPH group had significantly higher levels compared to the controls (p<0.05). However, serum arginase levels in all groups had no statistically significant correlation with PAP and PSA. Serum arginase activity correlated inversely with the Gleason grades. These results suggest that serum arginase assay may be used for the pretreatment evaluation of patients with prostatic diseases.
Similar content being viewed by others
References
Pretlow II, T. G., Harris, B. E., Bradley, E. L. Jr., Bueschen, A. J., Lloyd, K. L., Pretlow, T. P.: Enzyme activities in prostatic carcinoma related to Gleason Grades. Cancer Res., 45, 442 (1985).
Rackley, R. R., Lewis, T. J., Preston, E. M., Delmoro, C. M., Bradley, E. L. Jr., Resnick, M. I., Pretlow, T. P., Pretlow II, T. G.: 5-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia. Cancer Res., 49, 3702 (1989).
Rackley, R. R., Lewis, T. J., Bradley, E. L. Jr., Levin, H. S., Resnick, M. I., Pretlow, T. P., Pretlow II, T. G.: Enzymatic activities in extracts of small (20±5 mg) samples of prostatic carcinoma. Anal. Biochem., 184, 128 (1990).
Pretlow II, T. G., Nagabhushan, M., Sy, M., Guo, Y., Pretlow, T. P.: Putative preneoplastic foci in the human prostate. J. Cell Biochem. (Suppl.), 19, 224 (1994).
Chab, D. W., Sell, S.: Tietz Textbook of Clinical Chemistry. W. B. Saunders Co., Pennsylvania 1994.
Statland, B. E., Winkel, P.: Clinical Chemistry Theory, Analysis and Correlation. Mosby-Year Book Inc., Missouri 1996.
Mellerup, B.: Colorimetric method for rapid determination of serum arginase. Clin. Chem., 13, 900 (1967).
Yamanaka, H., Mayuzumi, T., Matsuoka, M., Shimazaki, J., Shida, K.: Arginase in human urogenital tumors. Gann., 63, 693 (1972).
Harris, B. E., Pretlow, T. P., Bradley, E. L. Jr., Whitehurst, G. B., Pretlow II, T. G.: Arginase activity in prostatic tissue of patients with benign prostatic hyperplasia and prostatic carcinoma. Cancer Res., 43, 3008 (1983).
Vafa, A. Z., Grover, P. K., Pretlow II, T. G., Resnick, M. I.: Study of activities of arginase, hexosaminidase and leucine aminopeptidase in prostate fluid. Urology, 42, 138 (1993).
Chinard, F. P.: Photometric estimation of proline and ornithine. J. Biol. Chem., 199, 91 (1952).
Gleason, D. F.: Classification of prostatic carcinomas. Cancer Chemother. Rep., 50, 125 (1966).
Gleason, D. F., Mellinger, G. T.: The Veterans Administration Cooperative Urological Research Group: Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J. Urol., 111, 58 (1974).
Gleason, D. F. and The Veterans Administration Cooperative Urological Research Group: Urologic Pathology: The Prostate. Lea & Febiger, Philadelphia 1977.
Williams-Ashman, H. G., Pegg, A. E., Lockwood, D. H.: Mechanisms and regulation of polyamine and putrescine biosynthesis in male genital glands and other tissues of mammals. Adv. Enzyme Regul., 7, 291 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Elgün, S., Keskineğe, A., Yilmaz, E. et al. Evaluation of Serum Arginase Activity in Benign Prostatic Hypertrophy and Prostatic Cancer. Int Urol Nephrol 31, 95–99 (1999). https://doi.org/10.1023/A:1007132109061
Issue Date:
DOI: https://doi.org/10.1023/A:1007132109061