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Indinavir Crystallization and Urolithiasis

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Abstract

The crystallization of indinavir in synthetic urine at different pH values and indinavir concentrations was kinetically studied. It was found that precipitation time notably decreases at urinary pH values above 6.0. The effects of some products as potential crystallization inhibitors were studied. Some natural saponins such as escin and glycyrrhizic acid provoked a notable increase in the precipitation time of indinavir, this pointing out their possible use to prevent renal tubular solid deposition.

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Authors and Affiliations

  1. Laboratory of Urolithiasis Research, University of Illes Balears, Palma de Mallorca, Spain

    F. Grases & A. Costa-Bauzá

  2. Hospital "Joan March", Palma de Mallorca, Spain

    R. García-González, A. Payeras & A. Bassa

  3. Hospital de Manacor, Palma de Mallorca, Spain

    J. J. Torres

  4. Hospital "Son Dureta", Palma de Mallorca, Spain

    A. Conte

Authors
  1. F. Grases
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  2. A. Costa-Bauzá
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  3. R. García-González
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  4. A. Payeras
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  5. A. Bassa
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  6. J. J. Torres
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  7. A. Conte
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Grases, F., Costa-Bauzá, A., García-González, R. et al. Indinavir Crystallization and Urolithiasis. Int Urol Nephrol 31, 23–29 (1999). https://doi.org/10.1023/A:1007111504518

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  • DOI: https://doi.org/10.1023/A:1007111504518

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