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Urodynamic Outcome after Transurethral Prostatectomy is Related to Percent Area Density of Prostate Smooth Muscle in Patients with Benign Prostatic Hyperplasia

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Abstract

We investigated the relationship between histological composition of the prostate and urodynamic outcome after transurethral resection of the prostate (TURP) in 27 patients with symptomatic benign prostatic hyperplasia (BPH). The histological analysis was performed using computer-assisted quantitative morphometry. Before and after TURP, group-specific urethral resistance factor (URA) was estimated by pressure-flow study. A significant correlation was found (p = 0.01) between the area density of prostate smooth muscle and the improvement in URA. However, no other histological components correlated with the improvement in URA. These facts suggest that the percent area density of prostate smooth muscle in prostatic adenoma appears to be a useful predictive factor for treatment of BPH.

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References

  1. Jensen, K. M. E., Jorgensen, J. B., Mogensen, P.: Urodynamics in prostatism. II. Prognostic value of pressure-flow study combined with stop-flow test. Scand. J. Urol. Nephrol. (Suppl.), 114, 72 (1988).

    Google Scholar 

  2. Caine, M.: Late results and complications of prostatectomy. In: Hinman, F. Jr. (eds): Benign Prostatic Hypertrophy. New York, Springer-Verlag, 971 (1983).

    Google Scholar 

  3. Mebust, W. K., Holtgrewe, H. L.: Current status of transurethral prostatectomy. World J. Urol., 6, 194 (1989).

    Google Scholar 

  4. Wennberg, J. E., Roos, N., Sola, L., Schori, A., Jaffe, R.: Use of claims data systems to evaluate health care outcomes. Mortality and reoperation following prostatectomy. J.A.M.A., 257, 933 (1987).

    PubMed  Google Scholar 

  5. Siegel, Y. I., Zaidel, L., Hammel, I., Zorczak, D.: Morphometrical evaluation of benign prostate hyperplasia. Eur. Urol., 18, 71 (1990).

    PubMed  Google Scholar 

  6. Shapiro, E., Hartano, V., Lepor, H.: Quantifying the smooth muscle content of the prostate using double-immunoenzymatic staining and color assisted image analysis. J. Urol., 147, 1167 (1992).

    PubMed  Google Scholar 

  7. Costa, P., Robert, M., Sarrazin, B., Mottet, N., Navratil, H.: Quantitative topographic distribution of epithelial and mesenchymal components in benign prostatic hypertrophy. Eur. Urol., 24, 120 (1993).

    PubMed  Google Scholar 

  8. Shapiro, E., Hartanto, V., Lepor, H.: The response to alpha blockade in benign prostatic hyperplasia is related to the percent area density of prostate smooth muscle. Prostate, 21, 297 (1992).

    PubMed  Google Scholar 

  9. Griffiths, D., Van Mastrigt, R., Bosch, R.: Quantification of urethral resistance and bladder function during voiding, with special reference to the effects of prostate size reduction on urethral obstruction due to benign prostatic hyperplasia. Neurouro. Urodyn., 8, 17 (1989).

    Google Scholar 

  10. Griffiths, D., Hofner, K., Van Mastrigt, R., Rollema, H. J., Spangberg, A., Gleason, D.: Standardization of terminology of lower urinary tract function. Pressure-flow studies of voiding, urethral resistance, and urethral obstruction. Neurouro. Urodyn., 16, 1 (1997).

    Google Scholar 

  11. Mebust, W. K., Holtgrewe, H. L., Cockett, A. T. K., Peters, P. C., Writing Committee: Transurethral prostatectomy. Immediate and postoperative complications. A cooperative study of 13 participating institutions evaluating 3,885 patients. J. Urol., 141, 243 (1989).

    PubMed  Google Scholar 

  12. Turner-Warwick, R., Whiteside, C. G., Worth, P. H., Milroy, E. J., Bates, C. P.: A urodynamic view of the clinical problems associated with bladder neck dysfunction and its treatment by endoscopic incision and trans-trigonal prostatectomy. Br. J. Urol., 45, 44 (1973).

    PubMed  Google Scholar 

  13. Shapiro, E., Becich, M. J., Hartanto, V., Lepor, H.: The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia. J. Urol., 147, 1293 (1992).

    PubMed  Google Scholar 

  14. Robert, M., Costa, P., Bressolle, F., Mottet, N., Navratil, H.: Percentage area density of epithelial and mesenchymal components in benign prostatic hyperplasia. Comparison of results between single biopsy, multiple biopsies and multiple tissue specimens. Br. J. Urol., 75, 317 (1995).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Yamagata University School of Medicine, Yamagata, Japan

    O. Ichiyanagi, I. Sasagawa, Y. Suzuki, M. Ishigooka & T. Nakada

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  1. O. Ichiyanagi
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  2. I. Sasagawa
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  3. Y. Suzuki
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  4. M. Ishigooka
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  5. T. Nakada
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Ichiyanagi, O., Sasagawa, I., Suzuki, Y. et al. Urodynamic Outcome after Transurethral Prostatectomy is Related to Percent Area Density of Prostate Smooth Muscle in Patients with Benign Prostatic Hyperplasia. Int Urol Nephrol 31, 787–791 (1999). https://doi.org/10.1023/A:1007101831120

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