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Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis

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Abstract

Animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. This is true for animal models of the primary fungal pathogens, Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. This review gives a brief background of human diseases associated with these organisms and describes the development, details, and utility of murine models of blastomycosis, as well as coccidioidomycosis and histoplasmosis.

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References

  1. Jensen HE. Animal models in mycology. In: Svendsen P, Hau J, eds. Handbook of Laboratory Animal Science. Boca Raton: CRC Press, 1994: vol II).

    Google Scholar 

  2. Polak A. Experimental models in antifungal chemotherapy. Mycoses 1998; 41: 1–30.

    Article  PubMed  CAS  Google Scholar 

  3. Stevens DA. Animal models in the evaluation of antifungal drugs. J Mycol Med 1996; 6 (Suppl I): 7–l0.

    Google Scholar 

  4. Rippon JW. Medical mycology: The pathogenic fungi and the pathogenic actinomycetes. (2nd ed.) Philadelphia, PA: W. B. Saunders Company, 1982.

    Google Scholar 

  5. Gilchrist TC. Protozoan dermatitis. J Cutan Dis 1894; 12: 496–9.

    Google Scholar 

  6. Gilchrist TC, Stokes WR. A case of pseudo-lupus vulgaris caused by a Blastomyces. J Exp Med 1898; 3: 53–78.

    PubMed  CAS  Google Scholar 

  7. Bradsher RW. Blastomycosis. Clin Infect Dis 1992; 14 (Suppl 1): S82–90.

    PubMed  Google Scholar 

  8. Al-Doory Y, DiSalvo AF, eds. Blastomycosis. New York: Plenum Publishing Corporation, 1992.

    Google Scholar 

  9. Bradsher RW. A clinician's view of blastomycosis. Curr Top Med Mycol 1993; 5: 181–200.

    PubMed  CAS  Google Scholar 

  10. Bradsher RW. Histoplasmosis and blastomycosis. Clin Infect Dis 1996; 22 (Suppl 2): S102–11.

    PubMed  Google Scholar 

  11. Bradsher RW. Systemic fungal infections: Diagnosis and treatment. I. Blastomycosis. Infect Dis Clin North Am 1988; 2: 877–98.

    PubMed  CAS  Google Scholar 

  12. Catanzaro A. Fungal pneumonias. Curr Opin Pulm Med 1997; 3: 146–50.

    PubMed  CAS  Google Scholar 

  13. Logsdon MT, Jones HE. North American blastomycosis: A review. Cutis 1979; 24: 524–7, 32–5.

    PubMed  CAS  Google Scholar 

  14. Brummer E, Clemons KV. Animal models of systemic mycoses. In: Miyaji M, ed. Animal Models in Medical Mycology. Boca Raton, FL: CRC Press, 1987: 79–95.

    Google Scholar 

  15. Schwartz J, Baum GL. Blastomycosis. Am J Clin Pathol 1951; 21: 999–1029.

    Google Scholar 

  16. Klein BS, Vergeront JM, DiSalvo AF, Kaufman L, Davis JP. Two outbreaks of blastomycosis along rivers in Wisconsin. Isolation of Blastomyces dermatitidis from riverbank soil and evidence of its transmission along waterways. Am Rev Respir Dis 1987; 136: 1333–8.

    PubMed  CAS  Google Scholar 

  17. Klein BS, Vergeront JM, Weeks RJ, et al. Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin. N Engl J Med 1986; 314: 529–34.

    Article  PubMed  CAS  Google Scholar 

  18. Sarosi GA, Davies SF. Blastomycosis – then and now. J Lab Clin Med 1987; 109: 731–2.

    PubMed  CAS  Google Scholar 

  19. Sarosi GA, Davies SF. Blastomycosis. Am Rev Respir Dis 1979; 120: 911–38.

    PubMed  CAS  Google Scholar 

  20. Pappagianis D. Epidemiology of coccidioidomycosis. Curr Top Med Mycol 1988; 2: 199–238.

    PubMed  CAS  Google Scholar 

  21. Drutz DJ, Catanzaro A. Coccidioidomycosis. Part I. Am Rev Respir Dis 1978; 117: 559–85.

    PubMed  CAS  Google Scholar 

  22. Drutz DJ, Catanzaro A. Coccidioidomycosis. Part II. Am Rev Respir Dis 1978; 117: 727–71.

    PubMed  CAS  Google Scholar 

  23. Galgiani JN. Coccidioidomycosis. West J Med 1993; 159: 153–71.

    PubMed  CAS  Google Scholar 

  24. Stevens DA. Coccidioidomycosis. New York: Plenum Medical, 1980.

    Google Scholar 

  25. Stevens DA. Coccidioidomycosis. N Engl J Med 1995; 332: 1077–82.

    PubMed  CAS  Google Scholar 

  26. Harrison WR, Merbs CF, Leathers CR. Evidence of coccidioidomycosis in the skeleton of an ancient Arizona Indian [letter]. J Infect Dis 1991; 164: 436–7.

    PubMed  CAS  Google Scholar 

  27. Ampel NM. Emerging disease issues and fungal pathogens associated with HIV infection. Emerg Infect Dis 1996; 2: 109–16.

    PubMed  CAS  Google Scholar 

  28. Bronnimann DA, Adam RD, Galgiani JN, et al. Coccidioidomycosis in the acquired immunodeficiency syndrome. Ann Intern Med 1987; 106: 372–9.

    PubMed  CAS  Google Scholar 

  29. Stansell JD. Pulmonary fungal infections in HIV-infected persons. Semin Respir Infect 1993; 8: 116–23.

    PubMed  CAS  Google Scholar 

  30. Centers for Disease Control (CDC). Coccidioidomycosis – United States, 1991–1992. MMWR 1993; 42: 21–4.

    Google Scholar 

  31. Galgiani JN. Coccidioidomycosis. In: Remington JS, Swartz MN, eds. Current Topics of Clinical and Infectious Diseases. Boston: Blackwell Science, Inc., 1997; 188–204.

    Google Scholar 

  32. Kirkland TN, Fierer J. Coccidioidomycosis; a reemerging infectious disease. Emerg Infect Dis 1996; 2: 192–9.

    Article  PubMed  CAS  Google Scholar 

  33. Drutz DJ, Huppert M. Coccidioidomycosis; factors affecting the host-parasite interaction. J Infect Dis 1983; 147: 372–90.

    PubMed  CAS  Google Scholar 

  34. Ampel NM, Wieden MA, Galgiani JN. Coccidioidomycosis; clinical update. Rev Infect Dis 1989; 11: 897–911.

    PubMed  CAS  Google Scholar 

  35. Darling ST. A protozoon general infection producing pseudotubercles in the lungs and focal necroses in the liver, spleen and lymph nodes. JAMA 1906; 46: 1283–5.

    Google Scholar 

  36. Wheat LJ. Histoplasmosis in Indianapolis. Clin Infect Dis 1992; 14 (Suppl 1): S91–9.

    PubMed  Google Scholar 

  37. Sarosi GA, Davies SF. Endemic mycosis complicating human immunodeficiency virus infection. West J Med 1996; 164: 335–40.

    PubMed  CAS  Google Scholar 

  38. Wheat J. Endemic mycoses in AIDS; a clinical review. Clin Microbiol Rev 1995; 8: 146–59.

    PubMed  CAS  Google Scholar 

  39. Stevens DA. Animal models of blastomycosis. Semin Respir Infect 1997; 12: 196–7.

    PubMed  CAS  Google Scholar 

  40. Denton JF, DiSalvo AF. Isolation of Blastomyces dermatitidis from natural sites in Augusta, Georgia. Am J Trop Med Hyg 1964; 13: 716–22.

    PubMed  CAS  Google Scholar 

  41. Graybill JR, Sun SH, Ahrens J. Treatment of murine coccidioidal meningitis with fluconazole (UK 49,858). J Med Vet Mycol 1986; 24: 113–9.

    PubMed  CAS  Google Scholar 

  42. Allendoerfer R, Yates RR, Sun SH, Graybill JR. Comparison of amphotericin B lipid complex with amphotericin B and SCH39304 in the treatment of murine coccidioidal meningitis. J Med Vet Mycol 1992; 30: 377–84.

    PubMed  CAS  Google Scholar 

  43. Cox RA. Immunology of the fungal diseases. Boca Raton, FL: CRC Press, Inc., 1989.

    Google Scholar 

  44. Cox RA, Magee DM. Production of tumor necrosis factor alpha, interleukin-1 alpha, and interleukin-6 during murine coccidioidomycosis. Infect Immun 1995; 63: 4178–80.

    PubMed  CAS  Google Scholar 

  45. Magee DM, Cox RA. Roles of gamma interferon and interleukin-4 in genetically determined resistance to Coccidioides immitis. Infect Immun 1995; 63: 3514–9.

    PubMed  CAS  Google Scholar 

  46. Magee DM, Cox RA. Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect Immun 1996; 64: 3609–13.

    PubMed  CAS  Google Scholar 

  47. Levine HB, Gonzalez-Ochoa A, Ten Eyck DR. Dermal sensitivity to Coccidioides immitis. A comparison of responses elicited inman by spherulin and coccidioidin. Am Rev Respir Dis 1973; 107: 379–86.

    PubMed  CAS  Google Scholar 

  48. Gatchel SL, Bjotvedt G, Leathers CR. Experimentally induced Histoplasma capsulatum infection in coyotes and a dog. J Am Vet Med Assoc 1986; 189: 1095–8.

    PubMed  CAS  Google Scholar 

  49. Silva-Ribeiro VL, Ferreira-da-Cruz MF, Wanke B, Galvao-Castro B. Canine histoplasmosis in Rio de Janeiro: natural and experimental infections. J Med Vet Mycol 1987; 25: 319–22.

    PubMed  CAS  Google Scholar 

  50. Clemons KV, Martinez M, Homola ME, Stevens DA. Therapy of systemic histoplasmosis in immunosuppressed mice with the triazole D0870. J Med Vet Mycol 1996; 34: 241–6.

    PubMed  CAS  Google Scholar 

  51. Clemons KV, Stevens DA. Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis [published erratum appears in Antimicrob Agents Chemother 1995 May; 39(5): 1210]. Antimicrob Agents Chemother 1995; 39: 778–80.

    PubMed  CAS  Google Scholar 

  52. Kobayashi GS, Little JR, Medoff G. In vitro and in vivo comparisons of amphotericin B and N–D-ornithyl amphotericin B methyl ester. Antimicrob Agents Chemother 1985; 27: 302–5.

    PubMed  CAS  Google Scholar 

  53. Kobayashi GS, Travis SJ, Medoff G. Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice. Antimicrob Agents Chemother 1987; 31: 2005–6.

    PubMed  CAS  Google Scholar 

  54. Kobayashi GS, Travis S, Medoff G. Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum. Antimicrob Agents Chemother 1986; 29: 660–2.

    PubMed  CAS  Google Scholar 

  55. Morozumi PA, Brummer E, Stevens DA. Strain differences in resistance to infection reversed by route of challenge: studies in blastomycosis. Infect Immun 1981; 34: 623–5.

    PubMed  CAS  Google Scholar 

  56. Morozumi PA, Halpern JW, Stevens DA. Susceptibility differences of inbred strains of mice to blastomycosis. Infect Immun 1981; 32: 160–8.

    PubMed  CAS  Google Scholar 

  57. Morozumi PA, Brummer E, Stevens DA. Cell-mediated immunoprotection in blastomycosis. Infect Immun 1982; 37: 670–8.

    PubMed  CAS  Google Scholar 

  58. Brass C, Stevens DA. Maturity as a critical determinant of resistance to fungal infections; studies in murine blastomycosis. Infect Immun 1982; 36: 387–95.

    PubMed  CAS  Google Scholar 

  59. Brass C, Volkmann CM, Klein HP, et al. Pathogen factors and host factors in murine pulmonary blastomycosis. Mycopathologia 1982; 78: 129–40.

    PubMed  CAS  Google Scholar 

  60. Harvey RP, Schmid ES, Carrington CC, Stevens DA. Mouse model of pulmonary blastomycosis; utility, simplicity, and quantitative parameters. Am Rev Respir Dis 1978; 117: 695–703.

    PubMed  CAS  Google Scholar 

  61. Sugar AM, Picard M, Noble L. Treatment of murine pulmonary blastomycosis with SCH39304, a new triazole antifungal agent. Antimicrob Agents Chemother 1990; 34: 896–8.

    PubMed  CAS  Google Scholar 

  62. Sugar AM, Picard M. Treatment of murine pulmonary blastomycosis with SCH51048, a broad-spectrum triazole antifungal agent. Antimicrob Agents Chemother 1995; 39: 996–7.

    PubMed  CAS  Google Scholar 

  63. Clemons KV, Hanson LH, Stevens DA. Activities of the triazole D0870 in vitro and against murine blastomycosis. Antimicrob Agents Chemother 1993; 37: 1177–9.

    PubMed  CAS  Google Scholar 

  64. Kirkland TN, Fierer J. Inbred mouse strains differ in resistance to lethal Coccidioides immitis infection. Infect Immun 1983; 40: 912–6.

    PubMed  CAS  Google Scholar 

  65. Clemons KV, Leathers CR, Lee KW. Systemic Coccidioides immitis infection in nude and beige mice. Infect Immun 1985; 47: 814–21.

    PubMed  CAS  Google Scholar 

  66. Clemons KV, Lutz JE, Stevens DA. Synergistic efficacy of interferon-γ and amphotericin B against histoplasmosis. 97th General Meeting of the American Society for Microbiology. Miami Beach; American Society forMicrobiology, 1997; F6, p. 273.

    Google Scholar 

  67. Clemons KV, Stevens DA. Addition and subtraction of interferon-gamma in cryptococcosis and histoplasmosis. XIII ISHAM. Salsomaggiore Terme, Parma, Italy, 1997; S89, p. 63.

    Google Scholar 

  68. Hector RF, Zimmer BL, Pappagianis D. Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. Antimicrob Agents Chemother 1990; 34: 587–93.

    PubMed  CAS  Google Scholar 

  69. Kobayashi GS, Travis SJ, Rinaldi MG, Medoff G. In vitro and in vivo activities of SCH39304, fiuconazole, and amphotericin B against Histoplasma capsulatum. Antimicrob Agents Chemother 1990; 34: 524–8.

    PubMed  CAS  Google Scholar 

  70. Stevens DA, Brummer E, DiSalvo AF, Ganer A. Virulent isolates and mutants of Blastomyces in mice: a legacy for studies of pathogenesis. Semin Respir Infect 1997; 12: 189–95.

    PubMed  CAS  Google Scholar 

  71. Pappagianis D, Zimmer BL, Theodoropoulos G, Plempel M, Hector RF. Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis. Antimicrob Agents Chemother 1990; 34: 1132–8.

    PubMed  CAS  Google Scholar 

  72. Deepe GS, Jr, Taylor CL, Bullock WE. Evolution of inflammatory response and cellular immune responses in a murine model of disseminated blastomycosis. Infect Immun 1985; 50: 183–9.

    PubMed  Google Scholar 

  73. Kitahara M, Kobayashi GS, Medoff G. Enhanced efficacy of amphotericin B and rifampicin combined in treatment of murine histoplasmosis and blastomycosis. J Infect Dis 1976; 133: 663–8.

    PubMed  CAS  Google Scholar 

  74. Clemons KV, Stevens DA. Therapeutic efficacy of a liposomal formulation of amphotericin B (AmBisome) against murine blastomycosis. J Antimicrob Chemother 1993; 32: 465–72.

    PubMed  CAS  Google Scholar 

  75. Brummer E, Hanson LH, Stevens DA. SCH39304 in the treatment of acute or established murine pulmonary blastomycosis. Antimicrob Agents Chemother 1991; 35: 788–90.

    PubMed  CAS  Google Scholar 

  76. Lefler E, Brummer E, Perlman AM, Stevens DA. Activities of the modified polyene N–D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay 19139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis. Antimicrob Agents Chemother 1985; 27: 363–6.

    PubMed  CAS  Google Scholar 

  77. Stevens DA, Brummer E, McEwen JG, Perlman AM. Comparison of fluconazole and ketoconazole in experimental murine blastomycosis. Rev Infect Dis 1990; 12 (Suppl 3): S304–6.

    PubMed  CAS  Google Scholar 

  78. Clemons KV, Hanson LH, Perlman AM, Stevens DA. Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis. Antimicrob Agents Chemother 1990; 34: 928–30.

    PubMed  CAS  Google Scholar 

  79. Clemons KV, Homola ME, Stevens DA. Activities of the triazole SCH51048 against Coccidioides immitis in vitro and in vivo. Antimicrob Agents Chemother 1995; 39: 1169–72.

    PubMed  CAS  Google Scholar 

  80. Clemons KV, Stevens DA. Comparative efficacies of amphotericin B lipid complex and amphotericin B deoxycholate suspension against murine blastomycosis. Antimicrob Agents Chemother 1991; 35: 2144–6.

    PubMed  CAS  Google Scholar 

  81. Huppert M, Sun SH, Gross AJ. Evaluation of an experimental animal model for testing antifungal substances. Antimicrob Agents Chemother 1972; 1: 367–72.

    PubMed  CAS  Google Scholar 

  82. Miyaji M, Nishimura K. Conversion of Coccidioides immitis from a mycelial form to spherules using the 'agarimplantation method'. Mycopathologia 1985; 90: 121–3.

    PubMed  CAS  Google Scholar 

  83. Petkus AF, Baum LL, Ellis RB, Stern M, Danley DL. Pure spherules of Coccidioides immitis in continuous culture. J Clin Microbiol 1985; 22: 165–7.

    PubMed  CAS  Google Scholar 

  84. Levine HB, Pappagianis D, Cobb JM. Development of vaccines for coccidioidomycosis. Mycopathologia 1970; 41: 177–85.

    CAS  Google Scholar 

  85. Kobayashi GS, Travis SJ, Medoff G. Comparison of fluconazole with amphotericin B in treatment of histoplasmosis in normal and immunosuppressed mice. Rev Infect Dis 1990; 12 (Suppi 3): S291–3.

    PubMed  CAS  Google Scholar 

  86. DiSalvo AF, Denton JF. Lipid content of four strains of Blastomyces dermatitidis of different mouse virulence. J Bacteriol 1963; 85: 927–31.

    PubMed  CAS  Google Scholar 

  87. Sugar AM, Picard M. Experimental blastomycosis pneumonia in mice by infection with conidia. J Med Vet Mycol 1988; 26: 321–6.

    PubMed  CAS  Google Scholar 

  88. Fierer J, Kirkland T, Finley F. Comparison of fluconazole and SDZ89-485 for therapy of experimental murine coccidioidomycosis. Antimicrob Agents Chemother 1990; 34: 13–6.

    PubMed  CAS  Google Scholar 

  89. Kirkland TN, Fierer J. Cyclosporin A inhibits Coccidioides immitis in vitro and in vivo. Antimicrob Agents Chemother 1983; 24: 921–4.

    PubMed  CAS  Google Scholar 

  90. Scalarone GM, Huntington RW. Circling syndrome and inner ear disease in mice infected intraperitoneally or intravenously with Coccidioides immitis spherule-endospore phase cultures. Mycopathologia 1983; 83: 75–86.

    PubMed  CAS  Google Scholar 

  91. Williams PL, Sobel RA, Sorensen KN, et al. A model of coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit. J Infect Dis 1998; 178: 1217–21.

    PubMed  CAS  Google Scholar 

  92. Huppert M, Sun SH, Gleason-Jordon I, Vukovich KR. Lung weight parallels disease severity in experimental coccidioidomycosis. Infect Immun 1976; 14: 1356–68.

    PubMed  CAS  Google Scholar 

  93. Kamei K, Brummer E, Clemons KV, Stevens DA. Induction of stress protein synthesis in Histoplasma capsulatum by heat, low pH and hydrogen peroxide. J Med Vet Mycol 1992; 30: 385–93.

    PubMed  CAS  Google Scholar 

  94. Arathoon EG, Brummer E, Stevens DA. Efficacy of itraconazole in blastomycosis in a murine model and comparison with ketoconazole. Mycoses 1989; 32 (Suppl 1): 109–12.

    PubMed  Google Scholar 

  95. Graybill JR, Palou E, Ahrens J. Treatment of murine histoplasmosis with UK 49,858 (fluconazole). Am Rev Respir Dis 1986; 134: 768–70.

    PubMed  CAS  Google Scholar 

  96. Tucker RM, Hanson LH, Brummer E, Stevens DA. Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis. Antimicrob Agents Chemother 1989; 33: 573–5.

    PubMed  CAS  Google Scholar 

  97. Clemons KV, Stevens DA. Comparative efficacy of amphotericin B colloidal dispersion and amphotericin B deoxycholate suspension in treatment of murine coccidioidomycosis. Antimicrob Agents Chemother 1991; 35: 1829–33.

    PubMed  CAS  Google Scholar 

  98. Hostetler JS, Hanson LH, Stevens DA. Effect of cyclodextrin on the pharmacology of antifungal oral azoles. Antimicrob Agents Chemother 1992; 36: 477–80.

    PubMed  CAS  Google Scholar 

  99. Levine HB, Stevens DA, Cobb JM, Gebhardt AE. Miconazole in coccidioidomycosis. I. Assays of activity in mice and in vitro. J Infect Dis 1975; 132: 407–14.

    PubMed  CAS  Google Scholar 

  100. Levine HB. R34000, a dioxolane imidazole in the therapy for experimental coccidioidomycosis. Comparison with miconazole and econazole. Chest 1976; 70: 755–9.

    PubMed  CAS  Google Scholar 

  101. Levine HB, Cobb JM. Oral therapy for experimental coccidioidomycosis with R41400 (ketoconazole), a new imidazole. Am Rev Respir Dis 1978; 118: 715–21.

    PubMed  CAS  Google Scholar 

  102. Levine HB, Ringel SM, Cobb JM. Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice. Chest 1978; 73: 202–6.

    PubMed  CAS  Google Scholar 

  103. Pappagianis D. Histopathologic response of mice to killed vaccines of Coccidioides immitis. J Invest Dermatol 1967; 49: 71–7.

    Article  PubMed  CAS  Google Scholar 

  104. Clemons KV, Stevens DA. Efficacies of two novel azole derivatives each containing a morpholine ring, UR-9746 and UR-9751, against systemic murine coccidioidomycosis. Antimicrob Agents Chemother 1997; 41: 200–3.

    PubMed  CAS  Google Scholar 

  105. Lutz JE, Clemons KV, Aristizabal BH, Stevens DA. Activity of the triazole SCH56592 against disseminated murine coccidioidomycosis. Antimicrob Agents Chemother 1997; 41: l558–61.

    Google Scholar 

  106. Clemons KV, Stevens DA. Utility of the triazole D0870 in the treatment of experimental systemic coccidioidomycosis. J Med Vet Mycol 1994; 32: 323–6.

    PubMed  CAS  Google Scholar 

  107. Galgiani JN, Sun SH, Clemons KV, Stevens DA. Activity of cilofungin against Coccidioides immitis: differential in vitro effects on mycelia and spherules correlated with in vivo studies. J Infect Dis 1990; 162: 944–8.

    PubMed  CAS  Google Scholar 

  108. Clemons KV, Stevens DA. Efficacy of Nikkomycin Z against experimental pulmonary blastomycosis. Antimicrob Agents Chemother 1997; 41: 2026–8.

    PubMed  CAS  Google Scholar 

  109. Brummer E, Hanson LH, Restrepo A, Stevens DA. In vivo and in vitro activation of pulmonary macrophages by IFNgamma for enhanced killing of Paracoccidioides brasiliensis or Blastomyces dermatitidis. J Immunol 1988; 140: 2786–9.

    PubMed  CAS  Google Scholar 

  110. Williams JE, Moser SA. Chronic murine pulmonary blastomycosis induced by intratracheally inoculated Blastomyces dermatitidis conidia. Am Rev Respir Dis 1987; 135: 17–25.

    PubMed  CAS  Google Scholar 

  111. Williams JE, Moser SA, Turner SH, Standard PG. Development of pulmonary infection in mice inoculated with Blastomyces dermatitidis conidia. Am J Respir CritCare Med 1994; 149: 500–9.

    CAS  Google Scholar 

  112. Brummer E. Role of neutrophils and macrophages in host resistance to systemic fungal infections. In: Kuystak E, ed. Immunology of Fungal Diseases. New York: Marcel Dekker, 1989; 273–89.

    Google Scholar 

  113. Pappagianis D, Hector R, Levine HB, Collins MS. Immunization of mice against coccidioidomycosis with a subcellular vaccine. Infect Immun 1979; 25: 440–5.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California, 95128, USA

    Kevin N. Sorensen, Karl V. Clemons & David A. Stevens

  2. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, 94305, USA

    Kevin N. Sorensen, Karl V. Clemons & David A. Stevens

  3. California Institute for Medical Research, San Jose, California, 95128, USA

    Kevin N. Sorensen, Karl V. Clemons & David A. Stevens

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Sorensen, K.N., Clemons, K.V. & Stevens, D.A. Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis. Mycopathologia 146, 53–65 (1999). https://doi.org/10.1023/A:1007081707287

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