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Yeasts and fluconazole susceptibility in the Philippines

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Abstract

Identification and fluconazole susceptibility of 579 yeasts isolated from patients in 16 medical centers throughout the Philippines in 1997–98 is reported. Speciation revealed the following distribution of yeasts (with percent occurrence): Candida albicans (49.6%); C. parapsilosis (17.2%);C. tropicalis (14.9%); C. glabrata(6.2%); C. pelliculosa (4.3%); C. krusei(2.4%); C. guilliermondii (1.9%); Trichosporon cutaneum (1.7%); Cryptococcus neoformans (0.9%); Candida famata (0.5%);C. lusitaniae (0.2%) and Saccharomyces cerevisiae (0.2%). Using an agar disk diffusion assay for fluconazole susceptibility it was determined that 94% of the isolates were susceptible, 5% dose-dependent susceptible and only 1% resistant. All isolates of C. albicans were susceptible (one being dose dependent sensitive) to fluconazole. The only yeasts resistant to fluconazole were: C. guillermondii (1 isolate), C. glabrata (3 isolates) and C. parapsilosis (1 isolate).

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Authors and Affiliations

  1. Department of Laboratory Medicine, Medical Mycology Unit, University of Santo Tomas School of Medicine & Surgery, Manila, Philippines

    Glenn S. Bulmer, Ma. Lourdes Marquez & Lily Co-Barcelona

  2. Merck Research Laboratories, Regulatory Affairs – International, Rahway, New Jersey, USA

    Robert A. Fromtling

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  1. Glenn S. Bulmer
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  2. Ma. Lourdes Marquez
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  3. Lily Co-Barcelona
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  4. Robert A. Fromtling
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Bulmer, G.S., Marquez, M.L., Co-Barcelona, L. et al. Yeasts and fluconazole susceptibility in the Philippines. Mycopathologia 146, 117–120 (1999). https://doi.org/10.1023/A:1007025212469

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  • DOI: https://doi.org/10.1023/A:1007025212469

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