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A structural model for the copper(II) site of Cu-Zn superoxide dismutase: preparation, crystal structure and properties of [Cu(Mebta)4(H2O)](ClO4)2·0.4EtOH (Mebta = 1-methylbenzotriazole)

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Abstract

Reaction of Cu(ClO4)2·6H2O with 1-methylbenzotriazole (Mebta) in EtOH yields [Cu(Mebta)4(H2O)] (ClO4)2·0.4EtOH in ca. 75% yield. The structure of this salt has been determined by single-crystal X-ray crystallography. Mebta behaves as a monodentate ligand binding through N(3). The metal coordination geometry is best described as distorted square pyramidal with the H2O ligand occupying the apical site. The complex was also characterized by molar conductivity, room-temperature effective magnetic moment and spectroscopic (i.r., far-i.r., u.v./vis, e.s.r.) studies. The data are discussed in terms of the nature of bonding and known structure. Comparison between the structural and spectroscopic properties of [Cu(Mebta)4(H2O)](ClO4)2·0.4EtOH and those of the CuII site of Cu–Zn superoxide dismutase shows that the former can be considered as a fairly good model for the latter.

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Authors and Affiliations

  1. Department of Chemistry, University of Patras, 265 00, Patras, Greece

    Konstantina Skorda, Spyros P. Perlepes, Catherine P. Raptopoulou & Robby Keuleers

  2. Institute for Materials Science, NCSR “Demokritos”, 153 10 Aghia Paraskevi Attikis, Greece

    Aris Terzis

  3. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, 451 10, Ioannina, Greece

    John C. Plakatouras

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  1. Konstantina Skorda
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  2. Spyros P. Perlepes
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  3. Catherine P. Raptopoulou
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  4. Robby Keuleers
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  5. Aris Terzis
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  6. John C. Plakatouras
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Skorda, K., Perlepes, S.P., Raptopoulou, C.P. et al. A structural model for the copper(II) site of Cu-Zn superoxide dismutase: preparation, crystal structure and properties of [Cu(Mebta)4(H2O)](ClO4)2·0.4EtOH (Mebta = 1-methylbenzotriazole). Transition Metal Chemistry 24, 541–545 (1999). https://doi.org/10.1023/A:1006988106184

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