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Relationships between proteasomes and viral gene products

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Abstract

The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition proteasome's endopeptidase activities are involved in the presentation of viral antigens. Viral proteins of different origin associate with the 20S and 26S complexes and interfere with their enzymatic activities. A major part of this review deals with the interactions between 20S proteasomes and the gene products of the human immunodeficiency virus (HIV) which has been studied in detail by our group.

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Authors and Affiliations

  1. Laboratoire OVGV UA INRA 987, équipe Protéasome & Auto-Surveillance Cellulaire, Université Blaise Pascal Clermont-Fd, 24 Avenue des Landais, 63177, Aubière Cedex, France

    Anne-Sophie Jarrousse, Karine Gautier, Sébastien Apcher, Saloua Badaoui, Hans-Peter Schmid & Franck Petit

  2. Laboratoire de Biochimie Appliquée, Université Blaise Pascal Clermont-Ferrand, 24 Avenue des Landais, 63177, Aubière Cedex, France

    Gérard Boissonnet & Marie-hélène Dadet

  3. Laboratoire de Biologie Cellulaire et Cytogénétique Moléculaire, Faculté de Médecine, Avenue Kennedy, 30900, N^imes, France

    Laurent Henry & Jean-Paul Bureau

Authors
  1. Anne-Sophie Jarrousse
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  2. Karine Gautier
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  3. Sébastien Apcher
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  4. Saloua Badaoui
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  5. Gérard Boissonnet
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  6. Marie-hélène Dadet
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  7. Laurent Henry
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  8. Jean-Paul Bureau
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  9. Hans-Peter Schmid
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  10. Franck Petit
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Jarrousse, AS., Gautier, K., Apcher, S. et al. Relationships between proteasomes and viral gene products. Mol Biol Rep 26, 113–117 (1999). https://doi.org/10.1023/A:1006982023524

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