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Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

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Abstract

The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-Ck dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-Ck has an important role in the regulation of cell cycle machinery.

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Authors and Affiliations

  1. Molecular Biology Unit, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh -, 16012, India

    D. Kaul & M. Kaur

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  1. D. Kaul
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  2. M. Kaur
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Kaul, D., Kaur, M. Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27). Mol Cell Biochem 200, 183–186 (1999). https://doi.org/10.1023/A:1006981614054

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