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Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling

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Abstract

Prior studies have established a role in insulin action for the tyrosine phosphorylation of substrates and their subsequent complexing with SH2 containing proteins. More recently, SH2 proteins have been identified which can tightly bind to the tyrosine phosphorylated insulin receptor. The major protein identified so far (called Grb-IR or Grb10) of this type appears to be present in at least 3 isoforms, varying in the presence of a pleckstrin homology domain and in the sequence of its amino terminus. The binding of this protein to the insulin receptor appears to inhibit signalling by the receptor. The present review will discuss the current knowledge of the structure and function of this protein.

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Authors and Affiliations

  1. Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78284-7764, USA

    Feng Liu

  2. Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Richard A. Roth

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  1. Feng Liu
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  2. Richard A. Roth
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Liu, F., Roth, R.A. Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling. Mol Cell Biochem 182, 73–78 (1998). https://doi.org/10.1023/A:1006899832614

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  • DOI: https://doi.org/10.1023/A:1006899832614

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