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Long chain fatty acids as modulators of gene transcription in preadipose cells

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Abstract

During the last years, it has been clearly established that long-chain fatty acids act as modulators of gene expression in various tissues, such as adipose tissue, intestine and liver. This transcriptional action of fatty acids explains in part adaptation mechanisms of tissues to nutritional changes and especially to high-fat diets by increasing expression of proteins involved in lipid catabolism in liver and fatty acid uptake and utilization in other tissues. It is now clearly demonstrated that some of these transcriptional effects of fatty acids are mediated by activation of specific nuclear hormone receptors, called peroxisome proliferator-activated receptors (PPARs). These findings will be discussed with a special reference to control of gene expression in preadipocytes and adipose tissue development.

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References

  1. Braughler JM, Mittal CK, Murad F: Purification of soluble guanylate cyclase. Proc Natl Acad Sci USA 76: 219–222, 1979

    Google Scholar 

  2. McPhail LC, Clayton CC, Snyderman R: A potential second messenger role for unsaturated fatty acids: Activation of Ca-dependent protein kinase. Science 224: 622–626, 1984

    Google Scholar 

  3. Ordway RN, Singer JJ, Walsh JV: Direct regulation of ion channels by fatty acids. Trends Neurosci 14: 96–100, 1991

    Google Scholar 

  4. Flatmark T, Nilsson A, Krames J, Eikhom TS, Fukami MH, Kryvi H, Christiansen EN: On the mechanism of induction of the enzyme systems for peroxisomal β-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil. Biochem Biophys Acta 962: 122–130, 1988

    Google Scholar 

  5. Faust IM, Johnson PR, Stern JS, Hirsch J: Diet-induced adipocyte number increase in adult rats: A new model of obesity. Am J Physiol 235: E279–E286, 1978

    Google Scholar 

  6. Clarke SD, Abraham S: Gene expression: nutrient control of pre-and post-transcriptional events. FASEB J 6: 3146–3152, 1992

    Google Scholar 

  7. Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferre P: Regulation of lipogenic enzyme gene expression by nutrients and hormones. FASEB J 8: 36–42, 1994

    Google Scholar 

  8. Landschulz KT, Jump DB, McDougald OA, Lane MD: Transcriptional control of stearoyl-CoA-desaturase-I gene by polyunsaturated fatty acids. Biochem Biophys Res Commun 200: 763–768, 1993

    Google Scholar 

  9. Clarke SD, Jump DB: Regulation of hepatic gene expression by dietary fats: A unique role for polyunsaturated fatty acids. In: C.D. Benardier and J.L. Hargrove (eds). Nutrition and Gene Expression. CRC Press, Boca Raton, 1993, p 227

    Google Scholar 

  10. Amri EZ, Bertrand B, Ailhaud G, Grimaldi P: Regulation of adipose cell differentiation: I. Fatty acids are inducers of the aP2 gene expression. J Lipid Res 32: 1449–1546, 1991

    Google Scholar 

  11. Amri EZ, Ailhaud G, Grimaldi P: Regulation of adipose cell differentiation: II: Kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone. J Lipid Res 32: 1457–1463, 1991

    Google Scholar 

  12. Amri EZ, Teboul L, Vannier C, Grimaldi P, Ailhaud G: Fatty acids regulate the expression of lipoprotein lipase and activity in preadipose and adipose cells. Biochem J 314: 541–546, 1996

    Google Scholar 

  13. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA: Induction of the aP2 gene by nonmetabolized long-chain fatty acids. Proc Natl Acad Sci USA 89: 10930–10934, 1992

    Google Scholar 

  14. Poirier H, Degrace P, Niot I, Bernard A, Besnard P: Localization and regulation of the putative membrane fatty acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). Eur J Biochem 238: 368–373, 1996

    Google Scholar 

  15. Niot I, Poirier H, Besnard P: Regulation of gene expression by fatty acids; special reference to fatty acid-binding proteins. Biochim (in press)

  16. Glatz JFC, van der Vusse GJ: Cellular fatty acid-binding proteins: Their function and physiological significance. Prog Lipid Res 35: 243–282, 1996

    Google Scholar 

  17. Issemann I, Green S: Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645–650, 1990

    Google Scholar 

  18. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM: PPARg2: Tissue-specific regulator of an adipocyte enhancer. Genes Dev 8: 1224–1234, 1994

    Google Scholar 

  19. Amri EZ, Bonino F, Ailhaud G, Abumrad NA, Grimaldi PA: Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. J Biol Chem 270: 2367–2371, 1995

    Google Scholar 

  20. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptors: Tissue distribution of PPARα, β, and γ in the adult rat. Endocrinology 137: 354–366, 1996

    Google Scholar 

  21. Osumi T, Wen JK, Hashimoto T: Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. Biochem Biophys Res Commun 175: 866–871, 1991

    Google Scholar 

  22. Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerx J: Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 270: 19269–19276, 1995

    Google Scholar 

  23. Issemann I, Prince RA, Tugwood JD, Green S: A role for fatty acids and liver fatty acid-binding protein in peroxisome proliferation. Biochem soc Trans 20: 824–827, 1992

    Google Scholar 

  24. Graves RA, Tontonoz P, Spiegelman BM: Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol 12: 1202–1208, 1992

    Google Scholar 

  25. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM: 15–deoxy-Δ12,14–prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83: 803–812, 1995

    Google Scholar 

  26. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM: A prostaglandin J2 metabolite binds to PPARγ and promotes adipocyte differentiation. Cell 83: 813–819, 1995

    Google Scholar 

  27. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W: The PPARα-leukotriene B4 pathway to inflammation control. Nature 384: 39–43, 1996

    Google Scholar 

  28. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA: Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272: 3406–3410, 1997

    Google Scholar 

  29. Lee SST, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012–3022, 1995

    Google Scholar 

  30. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM: Differential activation of adipogenesis by multiple PPAR isoforms. Genes & Dev 10: 974–984, 1996

    Google Scholar 

  31. Klyde BJ, Hirsch J: Increased cellular proliferation in adipose tissue of adult rats fed a high-fat diet. J Lip Res 20: 705–715, 1979

    Google Scholar 

  32. Shillabeer G, Lau DC: Regulation of new fat cell formation in rats: The role of dietary fats. J Lipid Res 35: 592–600, 1994

    Google Scholar 

  33. Amri EZ, Ailhaud G, Grimaldi PA: Fatty acids as signal transducing molecules: Involvment in the differentiation of preadipose to adipose cells. J Lipid Res 35: 930–937, 1994

    Google Scholar 

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Authors and Affiliations

  1. INSERM U 470, Centre de Biochimie, UFR Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, Nice, France

    Paul A. Grimaldi, Lydia Teboul, Danielle Gaillard, Anne V. Armengod & Ez Z. Amri

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  1. Paul A. Grimaldi
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  2. Lydia Teboul
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  3. Danielle Gaillard
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  4. Anne V. Armengod
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  5. Ez Z. Amri
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Grimaldi, P.A., Teboul, L., Gaillard, D. et al. Long chain fatty acids as modulators of gene transcription in preadipose cells. Mol Cell Biochem 192, 63–68 (1999). https://doi.org/10.1023/A:1006899027441

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