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Decavanadate possesses α-adrenergic agonist activity and a structural motif common with trans-β form of noradrenaline

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Abstract

Decavanadate, an inorganic polymer of vanadate, produced contraction of rat aortic rings at a relatively high concentration compared to phenylephrine, an agonist of α-adrenergic receptor. This effect was blocked by two known a-adrenergic receptor antagonists, prazosin and phenoxybenzamine. Decavanadate, formed by possible dimerization of V5 under acid conditions, possessed a structural feature of two pairs of unshared oxygen atoms at a distance of 3.12 Å, not found in its constituents of V4 or V5. A structural motif of O..O..O using such oxygen atoms is recognized in decavanadate. This matches with a similar motif of N..O..O that uses the essential amino and hydroxyl groups of the side-chain and the m-hydroxyl group in trans-b form of noradrenaline. The interaction of such a structural motif with the membrane receptor is likely to be the basis of the unusual noradrenaline-mimic action of decavanadate.

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Authors and Affiliations

  1. Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012, India

    H.N. Ravishankar, Aparna V.S. Rao, P. Kalyani, G. Sharada & T. Ramasarma

  2. Department of Pharmacology, St. John's Medical College, Bangalore, 560 034, India

    B.V. Venkataraman

  3. Naval Research Laboratory, Centre for Bio/Molecular Science Engineering, Washington D.C, 20375, USA

    K. Namboodiri & B. Gahor

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  1. B.V. Venkataraman
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  2. H.N. Ravishankar
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  3. Aparna V.S. Rao
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  4. P. Kalyani
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  5. G. Sharada
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  6. K. Namboodiri
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  7. B. Gahor
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  8. T. Ramasarma
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Venkataraman, B., Ravishankar, H., Rao, A.V. et al. Decavanadate possesses α-adrenergic agonist activity and a structural motif common with trans-β form of noradrenaline. Mol Cell Biochem 169, 27–36 (1997). https://doi.org/10.1023/A:1006882408983

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