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Proteasome and myogenesis

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Abstract

In this report, we examine the involvement of the ubiquitin-proteasome pathway during fusion and differentiation of myoblast primary cell cultures. Up-regulation of proteasome was observed at the maximum fusion rate and was preceded by an increase of unidentified ubiquitin-conjugates. Cell permeable proteasome inhibitors prevent fusion as do antisense oligodesoxyribonucleotides targetted to three proteasome subunits. Identical results were obtained using E3 ubiquitin-ligases dipeptide inhibitor. Involvement of the ubiquitin-proteasome pathway in the regulation of myogenic factors was hypothetized.

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Authors and Affiliations

  1. ENSSTAB, Laboratoire de Biochimie et Technologie des Aliments, URA-INRA, Université Bordeaux 1, Avenue des Facultés, 33405, Talence Cedex, France

    Florence Gardrat, Valérie Montel, Jacques Raymond* & Jean Louis Azanza

Authors
  1. Florence Gardrat
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  2. Valérie Montel
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  3. Jacques Raymond*
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  4. Jean Louis Azanza
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Gardrat, F., Montel, V., Raymond*, J. et al. Proteasome and myogenesis. Mol Biol Rep 24, 77–81 (1997). https://doi.org/10.1023/A:1006877214153

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