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Effect of polar glycopeptidolipids from Mycobacterium Chelonae (GPLp-Mc) on phagocytosis and superoxide anion production of macrophages from mice. Influence of physical activity

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Abstract

It is not clear how macrophages respond to exercise when the immune system is previously activated. The aim of the present work was to determine the response of macrophages to exercise in already immunostimulated animals with polar glycopeptidolipids extracted from Mycobacterium chelonae (GPLp-Mc). Results showed an increased phagocytosis and O2 - production in murine macrophages induced by the intraperitoneal administration of 25 mg/kg body weight of GPLp-Mc. In addition exercise stimulated phagocytic activity and decreased the O2 - production of these cells. Unexpectedly, exercise did not potentiate the immunostimulatory effect of GPLp-Mc. However, we can conclude that the effect of exercise is not detrimental to immunostimulated animals.

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Authors and Affiliations

  1. Department of Animal Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain

    Juan José García García, Carmen Barriga, Ana Beatriz Rodríguez & Eduardo Ortega

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  1. Juan José García García
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  2. Carmen Barriga
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  3. Ana Beatriz Rodríguez
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  4. Eduardo Ortega
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García García, J.J., Barriga, C., Rodríguez, A.B. et al. Effect of polar glycopeptidolipids from Mycobacterium Chelonae (GPLp-Mc) on phagocytosis and superoxide anion production of macrophages from mice. Influence of physical activity. Mol Cell Biochem 183, 159–163 (1998). https://doi.org/10.1023/A:1006848726642

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  • DOI: https://doi.org/10.1023/A:1006848726642

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