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Synthesis, structure and anti-acetylcholinesterase activity of 4β-methoxymethyl-4β-demethyl territrem B

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Abstract

4β-Methoxymethyl-4β-demethyl territrem B [5] was synthesized from 4β-hydroxymethyl-β-demethyl territrem B [4] by treatment with dimethyl sulfate in methanolic NaOH. The structure of 5 was elucidated by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 × 10-5 M, which indicated 0.4% of the anti-AChE activity of territrem B [2].

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Authors and Affiliations

  1. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan ROC

    Fu-Chuo Peng

  2. Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan ROC

    Jur-Shan Cheng

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  1. Fu-Chuo Peng
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  2. Jur-Shan Cheng
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Peng, FC., Cheng, JS. Synthesis, structure and anti-acetylcholinesterase activity of 4β-methoxymethyl-4β-demethyl territrem B. Mycopathologia 137, 125–128 (1997). https://doi.org/10.1023/A:1006845621623

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  • DOI: https://doi.org/10.1023/A:1006845621623

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