Role of aldehydes in fructose induced hypertension

Molecular and Cellular Biochemistry volume 181, pages1–9(1998)Cite this article

Abstract

Aldehydes are formed in tissues of humans and animals as intermediates of glucose and fructose metabolism and due to lipid peroxidation. N-acetyl cysteine (NAC), an analogue of the dietary amino acid cysteine, binds aldehydes thus preventing their damaging effect on physiological proteins. We measured systolic blood pressure (SBP), platelet cytosolic free calcium [Ca2+]i and tissue aldehyde conjugates in fructose induced hypertensive Wistar-Kyoto (WKY) rats and examined the effect of NAC in the diet on these parameters. Animals age 7 weeks were divided into three groups of 6 animals each and were treated as follows: WKY-control (chow diet and normal drinking water); WKY-Fructose (chow diet and 4% fructose in drinking water); WKY-Fructose+NAC (1.5% NAC in chow diet and 4% fructose in drinking water). After 11 weeks, systolic blood pressure, platelet [Ca2+]i and kidney aldehyde conjugates were all significantly higher in fructose treated rats. NAC treatment prevented these changes. These results suggest that aldehydes may be the cause of fructose induced hypertension and elevated cytosolic free calcium.

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Affiliations

  1. Department of Medicine, Laboratory Medicine and Community Medicine, Health Sciences Centre, Memorial University of Newfoundland, St. John's, Newfoundland, A1B 3V6, Canada

    Sudesh Vasdev, Carol Ann Ford, Linda Longerich, Veeresh Gadag & S. Wadhawan

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  1. Sudesh Vasdev
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  2. Carol Ann Ford
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  3. Linda Longerich
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  4. Veeresh Gadag
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  5. S. Wadhawan
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Vasdev, S., Ford, C.A., Longerich, L. et al. Role of aldehydes in fructose induced hypertension. Mol Cell Biochem 181, 1–9 (1998). https://doi.org/10.1023/A:1006844222963

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  • fructose
  • aldehydes
  • hypertension