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Molecular and Cellular Biochemistry

, Volume 181, Issue 1–2, pp 1–9 | Cite as

Role of aldehydes in fructose induced hypertension

  • Sudesh Vasdev
  • Carol Ann Ford
  • Linda Longerich
  • Veeresh Gadag
  • S. Wadhawan
Article

Abstract

Aldehydes are formed in tissues of humans and animals as intermediates of glucose and fructose metabolism and due to lipid peroxidation. N-acetyl cysteine (NAC), an analogue of the dietary amino acid cysteine, binds aldehydes thus preventing their damaging effect on physiological proteins. We measured systolic blood pressure (SBP), platelet cytosolic free calcium [Ca2+]i and tissue aldehyde conjugates in fructose induced hypertensive Wistar-Kyoto (WKY) rats and examined the effect of NAC in the diet on these parameters. Animals age 7 weeks were divided into three groups of 6 animals each and were treated as follows: WKY-control (chow diet and normal drinking water); WKY-Fructose (chow diet and 4% fructose in drinking water); WKY-Fructose+NAC (1.5% NAC in chow diet and 4% fructose in drinking water). After 11 weeks, systolic blood pressure, platelet [Ca2+]i and kidney aldehyde conjugates were all significantly higher in fructose treated rats. NAC treatment prevented these changes. These results suggest that aldehydes may be the cause of fructose induced hypertension and elevated cytosolic free calcium.

fructose aldehydes hypertension 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Sudesh Vasdev
    • 1
  • Carol Ann Ford
    • 1
  • Linda Longerich
    • 1
  • Veeresh Gadag
    • 1
  • S. Wadhawan
    • 1
  1. 1.Department of Medicine, Laboratory Medicine and Community Medicine, Health Sciences CentreMemorial University of NewfoundlandSt. John'sCanada

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