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Receptor- ‘Ck’ dependent signalling regulates the LDL-receptor gene transcription

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Abstract

Evidence of a novel receptor, having affinity for cholesterol in lipoproteins and intrinsic tyrosine kinase activity (designated as Receptor ‘Ck’) prompted us to explore its role in LDL-dependent transcriptional regulation of apoprotein-B specific LDL receptor gene in human lymphocytes. The results of this study revealed that LDL-dependent activation of this Receptor ‘Ck’ was essential for the regulation of apoprotein-B specific LDL receptor gene transcription. Further, by using various blockers of as well as simulating the Receptor ‘Ck’-dependent signalling in human lymphocytes, we were able to show that Receptor ‘Ck’-dependent signalling was involved in the LDL-dependent transcriptional regulation of 160 kDa apoprotein B specific LDL receptor gene. Based upon these results, we conclude that cholesterol derived from LDL catabolism within the cell does not have any role in the transcriptional regulation of apoprotein B specific LDL receptor gene.

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Authors and Affiliations

  1. Molecular Biology Unit, Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Rajeev Goel, Jarnail Singh & D. Kaul

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  1. Rajeev Goel
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  2. Jarnail Singh
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  3. D. Kaul
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Goel, R., Singh, J. & Kaul, D. Receptor- ‘Ck’ dependent signalling regulates the LDL-receptor gene transcription. Mol Cell Biochem 169, 79–83 (1997). https://doi.org/10.1023/A:1006806118493

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