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Elevated Plasma Levels of 90K (Mac-2 BP) Immunostimulatory Glycoprotein in HIV-1-Infected Children

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Abstract

90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 μg/ml) were higher than in HIV-1 uninfected control group (6.3 μg/ml; P < 0.05). 90K levels of HIV-1-infected children classified as stage B and C (median, 15.0 μg/ml and 22.7 μg/ml, respectively) were higher compared to children with stage A disease (median, 7.0 μg/ml; P < 0.05). A positive correlation (r = 0.5; P < 0.05) was found between 90K levels and HIV-1 RNA levels in 137 plasma samples of 18 HIV-1-infected children collected during a period of 1 year. No correlation was found between 90K levels and CD4 cell counts. These results suggest that 90K plasma levels may represent a novel marker of disease progression in HIV-1-infected children.

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Authors and Affiliations

  1. Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., 60528, Frankfurt/M., Germany

    B. Gr¨oschel, J. J. Braner, H. W. Doerr & J. Cinatl Jr.

  2. Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt/M., Germany

    M. Funk & R. Linde

  3. Department of Oncology and Neurosciences, University G. D'Annunzio, Chieti, Italy

    S. Iacobelli

Authors
  1. B. Gr¨oschel
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  2. J. J. Braner
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  3. M. Funk
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  4. R. Linde
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  5. H. W. Doerr
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  6. J. Cinatl Jr.
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  7. S. Iacobelli
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Gr¨oschel, B., Braner, J.J., Funk, M. et al. Elevated Plasma Levels of 90K (Mac-2 BP) Immunostimulatory Glycoprotein in HIV-1-Infected Children. J Clin Immunol 20, 117–122 (2000). https://doi.org/10.1023/A:1006634530672

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