Abstract
To develop a comprehensive ‘cells-first’ approach to the origin of life, we propose that protocells form spontaneously and that the fission and fusion of these protocells drives the dynamics of their evolution. The fitness criterion for this evolution is taken to be the the stability (conservation) of domains in the protocellular membrane as determined by non-covalent molecular associations between the amphiphiles of the membrane and a subset of the macromolecules in the protocell. In the presence of a source of free energy the macromolecular content of the protocell (co-)evolves as the result of (domain-dependent) membrane-catalysed polymerisation of the prebiotic constituents delivered to the protocell by fusion. The metabolism of the cell therefore (co-)evolves on a rugged fitness landscape. We indicate how domain evolution with the same fitness criterion can potentially give rise to coding. Membrane domains may therefore provide the link between protocells and the RNA/DNA-world.
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Bachmann, P. A., Luisi, P. L. and Lang, J.: 1992, Nature 357, 57.
Baeza, I., Wong, C., Mondragon, R., Gonzalez, S., Ibanez, M., Farfan, N. and Arguetto, C.: 1994, J. Mol. Evol. 39, 560.
Bernal, J. D.: 1949, Proc. Phys. Soc. A62, 537–558.
Bohler, C., Hill, A. R. and Orgel, L. E.: 1996, Origins Life Evol. Biosphere 26, 1.
Cairns-Smith, A. G.: 1982, Genetic Takeover and the Mineral Origins of Life (Cambridge, University Press).
Cavalier-Smith, T.: 1987, Cold Spring Harbor Symp. Quant. Biol. LII.
Chakrabarti, A. C. and Deamer, D. W.: 1982, Biochim. et Biophys. Acta 1111, 171–177.
Deamer, D. W.: 1986, Origins Life Evol. Biosphere 17, 3–25.
Deamer, D. W. and Fleischaker, G. R.: 1994, Origins of Life, Jones and Bartlett.
Deamer, D. W. and Pashly, R. M.: 1989, in Origins Life Evol. Biosphere 19, 21–38.
Dyson, F. J.: 1985, Origins of Life, Cambridge U.P., Cambridge, U.K.
Eigen, M.: 1971, Naturwissenschaften 58, 465–523.
Eigen, M. and Schuster, P.: 1997, Naturwissenschaften 64, 541–565.
Ferris, J. P.: 1987, Cold Spring Harbor Symp. Quant. Biol 52, 29.
Ferris, J. P., Huang, C.H. and Hagen, W. R.: 1988, Origins Life Evol. Biosphere 18, 121.
Ferris, J. P., Kamaluddin, and Ertem, G.: 1990, Origins Life Evol. Biosphere 20, 279.
Ferris, J. P., Hill, A. R., Liu, R. H. and Orgel, L. E.: 1996, Nature 381, 59.
Fox, S. W.: 1965, Nature 205, 328–340.
Fox, S. W. and Hadrada, K.: 1958, Science 128, 1214.
Glaser, M.: 1993, Curr. Opin. Struct. Biol. 68, 161–168.
Hammes, G. G. and Schullery, S. E.: 1970, Biochemistry 9, 2555.
Hargreaves et al.: 1977, Nature 266, 78.
Joyce, G. F.: 1991, New Biologist 3, 399–407.
Koch, A. L.: 1985, J. Mol. Evol. 21, 270–277.
Kauffman, S. A.: 1993, The Origins of Order, Oxford, U.P.
Kinnunen, P. K. J., Anu Kõiv, A., Lehtonen, J. Y. A., Rytömaa, M. and Mustonen, P.: 1994, Chem. Phys. Lipids 73, 181–207.
Kvenvolden, K. et al.: 1970, Nature 228, 923–926.
Larralade, R., Robertson, M. P. and Miller, S. L.: 1995, Proc. Nat. Acad. Sci. 92, 8158.
Luisi, P. L.: 1993, in W. D. Stein and F. J. Varela (eds.), Thinking about Biology; SFI Studies in the Science of Complexity Vol. III, Addison-Wesley.
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K. and Ghadiri, M. R.: 1996, Nature 382, 525.
Lentz, B. R.: 1994, Chem. Phys. Lipids 73, 91.
MacIntyre, F.: 1970, in J. Walker and W. H. Freeman (eds.) The Physics of Everyday Phenomena, Readings from Scientific American, San Francisco.
Melo, E. C. C., Lourtie, I.M. G., Sankaram, M. B., Thompson, T. E. and Vaz, W. L. C.: 1992, Biophys. J. 63, 1506–1512.
Miller, S. L.: 1987, Cold Spring Harbor Symp. Quant. Biol. 52, 17.
Morowitz, H. J., Heinz, B. and Deamer, D. W.: 1988, in Origins Life Evol. Biosphere 18, 281–187.
Mouritsen, O. G. and Jørgensen, K.: 1994, Chem. Phys. Lipids 73, 3–25.
Needham, J.: 1968, Order and Life, Cambridge, Mass.
Norris, V.: 1989, J. Theor. Biol. 139, 117–128.
Norris, V.: 1990, J. Mol. Biol. 215, 67–71.
Norris, V.: 1993, J. Theor. Biol. 164, 239–244.
Norris, V.: 1994, Mol. Microbiol. 15, 985–987.
Norris, V.: 1995, Mol. Microbiol. 16, 1051–1057.
Norris, V. and Madsen, M. S., 1995, J. Mol. Biol. 253, 739–748.
Norris, V. and Manners, W.: 1993, Biophys. J. 64, 1691.
Orgel, L. E.: 1992, Nature 358, 203.
Oro, J., Basile, B., Cortes, S., Shen, C. and Yamron, T.: 1984, Origins of Life 14, 237.
Papahadjopoulos, D., Vail, W. J., Newton, C., Nir, S., Jacobson, K., Poste, G. and Lazo, R.: 1977, Biochim. Biophys. Acta 465, 579.
Rao, M., Eichberg, J. and Oro, J.: 1982, J. Mol. Evol. 18, 196–202.
Radler, J. O., Koltover, I., Salditt, T. and Safinya, C. R.: 1997, Science 275, 810.
Rokhsar, D. S., Anderson, P. W. and Stein, D. L.: 1986, J. Mol. Evol. 23, 119–126.
Safran, S. A.: 1994, Statistical Thermodynamics of Surfaces, Interfaces, and Membranes, AddisonWesley.
Tocanne, J.F., Cezanne, L., Lopez, A., Piknova, B., Schram, V., Tournier, J.F. and Welby, M.: 1994, Chem. Phys. Lipids 73, 139–158.
Wachtershauser, G.: 1988, Microbiol. Rev. 52, 452–484.
Yarus, M.: 1993, in The RNA World, Cold Harbour Spring Lab. Press.
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Norris, V., Raine, D.J. A Fission-Fusion Origin for Life. Orig Life Evol Biosph 28, 523–537 (1998). https://doi.org/10.1023/A:1006568226145
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DOI: https://doi.org/10.1023/A:1006568226145