Skip to main content
SpringerLink
Log in

Cytogenetic Profile of Primary Pituitary Germinoma

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

We present a case of a germinoma in the sellar region of a 10-year-old female patient who presented with a history of polydipsia, polyuria and visual disturbances. The tumor was resected and histologically analyzed. Interphase cytogenetics was performed using chromosome specific (peri)-centromeric DNA probes for all the somatic and X chromosomes on fresh frozen tissues. Fluorescent in situ cell hybridization demonstrated accumulated cytogenetic abnormalities involving significant alterations of chromosome 1, 4, 5/19 and 15. The child was treated postoperatively by radiation and now appears well with only minor neurological deficits. At 3-year follow-up no recurrent tumor mass could be demonstrated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ide M, Jimbo M, Yamamoto M, Hagiwara S, Aiba M, Kubo O: Spontaneous regression of primary intracranial germinoma. A case report. Cancer 79(3): 558-563, 1997

    Google Scholar 

  2. Matsutani M, Sano K, Takakura K, Fugimaki T, Nakamura O, Funata N, Seto T: Primary intracranial germ cell tumours: a clinical analysis of 153 histologically verified cases. J Neurosurg 86: 446-455, 1997

    Google Scholar 

  3. Albrecht S, Armstrong DL, Mahoney DH, Cheek WR, Cooley LD: Cytogenetic demonstration of gene amplification in a primary intracranial germ cell tumor. Genes Chromosom Cancer 6: 61-63, 1993

    Google Scholar 

  4. Bhattacharjee MB, Armstrong DD, Vogel H, Cooley LD: Cytogenetic analysis of 120 primary pediatric brain tumors and literature review. Cancer Genet Cytogenet 97(1): 39-53, 1997

    Google Scholar 

  5. Sainati L, Bolcato S, Montaldi A, Celli P, Stella M, Leszl A, Silvestro L, Perilongo G, Cordero di Montezemolo L, Basso G: Cytogenetics of pediatric central nervous system tumours. Cancer Genet Cytogenet 91: 13-27, 1996

    Google Scholar 

  6. Pajor L, Szuhai K, Méhes G, Kosztolányi Gy, JáksóP, Lendvai G, Szanyi I, Kajtár P: Combinated metaphase, interphase cytogenetic and flowcytometric analysis of DNA content of pediatric acute lymphoblastic leukaemia. Cytometry 34: 87-94, 1998

    Google Scholar 

  7. Kohler L: Case of the month. April 1996-pituitary tumour. Brain Pathol 6(4): 531-532, 1996

    Google Scholar 

  8. Grimoldi N, Tomei G, Stankov B, Lucini V, Masini B, Caputo V, Repetti ML, Lazzarini G, Gaini SM, Lucarini C, Fraschini F, Villani R: Neuroendocrine, immunohistochemical, and ultrastructural study of pineal region tumors. J Pineal Res; 25(3): 147-158, 1998

    Google Scholar 

  9. Paulino AC, Wen BC, Mohideen MN: Controversies in the management of intracranial germinomas. Oncology (Huntingt) 13(4): 513-521; discussion 521-522, 528-531, 1999

    Google Scholar 

  10. ShibamotoY, Sasai K, Kokubo M, Hiraoka M: Salvage radiation therapy for intracranial germinoma recurring after primary chemotherapy. J Neuro-Oncol 44(2): 181-185, 1999

    Google Scholar 

  11. Murty VV, Reuter VE, Bosl GJ, Chaganti RS: Deletion mapping identifies loss of heterozygosity at 5p15.1-15.2, 5q11 and 5q34-35 in human male germ cell tumors. Oncogene 12(12): 2719-2723, 1996

    Google Scholar 

  12. Sinke RJ, van Asseldonk M, de Bruijn D, Strijk JA, Merkx G, Olde-Weghuis D, de Jong B, Oosterhuis JW, Geurts van Kessel A: Towards the isolation of a human malignant extragonadal germ cell tumour-associated breakpoint in chromosome 11q13. APMIS 106(1): 73-78, discussion 78-79, 1998

    Google Scholar 

  13. de Bruin TW, Slater RM, Defferrari R, Geurts van Kessel A, Suijkerbuijk RF, Jansen G, de Jong B, Oosterhius JW: Isochromosome 12p positive pineal germ cell tumor. Cancer Res 15: 54(6): 1542-1544, 1994

    Google Scholar 

  14. Lemos JA, Barbieri-Neto J, Casartelli C: Primary intracranial germ cell tumors without an isochromosome 12p. Cancer Genet Cytogenet 100(2): 124-128, 1998

    Google Scholar 

  15. Nakashima T, Nishimura Y, Sakai N, Yamada H, Hara A: Germinoma in cerebral hemisphere associated with Down syndrome. Childs Nerv Syst 13(10): 563-566, 1997

    Google Scholar 

  16. Wong TT, Ho DM, Chang TK, Yang DD, Lee LS: Familial neurofibromatosis 1 with germinoma involving the basal ganglion and thalamus. Childs Nerv Syst 11(8): 456-458, 1995

    Google Scholar 

  17. Feng X, Zhang S, Ichikawa T, Koga H, Washiyama K, Motoyama T, Kumanishi T: Intracranial germ cell tumors: detection of p53 gene mutations by single-strand conformation polymorphism analysis. Jpn J Cancer Res 86(6): 555-56l, 1995

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Medical School, University of Pécs, Pécs, Hungary

    É. Gömöri, D.J. Halbauer, E. Balázs & L. Pajor

  2. Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary

    T. Dóczi

  3. Department of Pediatric Oncology, Medical School, University of Pécs, Pécs, Hungary

    P. Kajtár

Authors
  1. É. Gömöri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D.J. Halbauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Dóczi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Balázs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Kajtár
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. Pajor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gömöri, É., Halbauer, D., Dóczi, T. et al. Cytogenetic Profile of Primary Pituitary Germinoma. J Neurooncol 50, 251–255 (2000). https://doi.org/10.1023/A:1006409217130

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1006409217130

Search

Navigation