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Pharmacokinetics and Dosage Regimen of Enrofloxacin in Buffalo Bulls after Intramuscular Administration

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Abstract

The disposition kinetics and dosage regimen of enrofloxacin were investigated in breeding buffalo bulls following a single intramuscular administration of 5 mg/kg. The absorption half-life, half-life of the terminal phase, apparent volume of distribution and total body clearance were 0.262±0.099 h, 1.97±0.23 h, 0.61±0.13 L/kg and 210.2±18.6 ml/(kg.h), respectively. Therapeutic plasma levels (≥1 μg/ml) were maintained for up to 6 h. A satisfactory intramuscular dosage regimen for enrofloxacin in buffalo bulls would be 8.5 mg/kg followed by 8.0 mg/kg at 8 h intervals.

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Authors and Affiliations

  1. Department of Veterinary and A.H. Extension, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India

    H.K. Verma

  2. Department of Animal Reproduction, Gynaecology and Obstetrics, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India

    G.R. Pangawkar

  3. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India

    R.K. Chaudhary & A.K. Srivastava

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  1. H.K. Verma
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  2. G.R. Pangawkar
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  3. R.K. Chaudhary
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  4. A.K. Srivastava
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Verma, H., Pangawkar, G., Chaudhary, R. et al. Pharmacokinetics and Dosage Regimen of Enrofloxacin in Buffalo Bulls after Intramuscular Administration. Vet Res Commun 23, 501–505 (1999). https://doi.org/10.1023/A:1006366507016

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  • DOI: https://doi.org/10.1023/A:1006366507016

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