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Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)

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Abstract

The role of chemotherapy in the treatment of non-smallcell lung cancer (NSCLC) has increased greatly in the past fewyears. While cytotoxic drugs are currently used both as singleagents and in combination for palliation in locally advanced andmetastatic disease, they have also been incorporated intomulti-modality treatment strategies of Stage I to Stage IIINSCLC. One of the main reasons for the increased acceptance ofchemotherapy is the development of new substances.

Among the most promising of these new drugs is theantimetabolite gemcitabine. Several single-arm gemcitabine PhaseII studies involving more than 400 patients show validatedresponse rates in more than 20% of the patients. Thesepositive results have also been confirmed in randomized Phase IIstudies. Gemcitabine's unique mechanism of action, its lack ofoverlapping toxicity with other agents, and its favorabletoxicity profile also define it as an ideal candidate forcombination therapy.

The activity seen with single-agent gemcitabine therapy canbe compared with that of cisplatin-etoposide combination therapy.Gemcitabine-cisplatin combination response rates range from31% to 54%, with a median survival time between 8.4and 15.4 months and a 1-year survival rate between 30% and59%. In addition to the clinical research ofgemcitabine-cisplatin combinations, gemcitabine has also beentested in various double and triple combinations withcarboplatin, paclitaxel, docetaxel, vinorelbine, and ifosfamide.Investigations combining gemcitabine with radiation therapy areon-going. The following review will summarize results fromrepresentative Phase I/II and III studies using gemcitabine forNSCLC patients.

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References

  1. Huang P, Chubb S, Hertel LW, Grindey GB, Plunkett W: Action of 2′.2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 51: 6110-6117, 1991

    Google Scholar 

  2. Hertel LW, Boder GB, Kroin JS, Rinzel SM, Poore GA, Todd GC, Grindey GB: Evaluation of the antitumor activity of Gemcitabine (2′.2′-difluoro-2′-deoxycytidine). Cancer Res 5(50): 4417-4422, 1990

    Google Scholar 

  3. Lund B, Kristjansen PEG, Hansen HH: Clinical and preclinical activity of 2′.2′-difluorodeoxycytidine (Gemcitabine). Cancer Treat Rev 19: 45-55, 1993

    Google Scholar 

  4. Noble S, Goa KL: Gemcitabine-a review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drugs54(3): 447-472, 1997

    Google Scholar 

  5. Thatcher N, Anderson H, Betticher DC, Ranson M: Symptomatic benefit from gemcitabine and other chemotherapy in advanced non-small cell lung cancer: changes in performance status and tumor-related symptoms. Anti-Cancer Drugs 6 (Suppl 6): 39-48, 1995

    Google Scholar 

  6. Abratt RP, Bezwoda WR, Falkson G, Goedhals L, Hacking T, Rugg TA: Efficacy and safety profile of gemcitabine in nonsmall cell lung cancer: a phase II study. J Clin Oncol 12: 1535-1550, 1994

    Google Scholar 

  7. Anderson H, Lund B, Bach F, Thatcher N, Walling J, Hansen HH: Single-agent activity of weekly Gemcitabine in advanced non-small cell lung cancer: a phase II study. J Clin Oncol 12: 1821-1826, 1994

    Google Scholar 

  8. Fukuoka M, Negoro S, Kudo S, Furuse K, Nishikawa H, Takada Y, Kamei T, Niitani H, Taguchi T: A late phase II study of Gemcitabine (LY188011) against non-small cell lung cancer. Jpn J Cancer Chemother 23(13): 1825-1832, 1996

    Google Scholar 

  9. Gatzemeier U, Shepherd FA, Le Chevalier T, Weynants P, Cottier B, Groen HJM, Rosso R, Mattson K, Cortes-Funes H, Tonato M, Burkes RL, Gottfried M, Voi M: Activity of Gemcitabine in patients with non-small cell lung cancer: a multicenter, extended phase II study. Eur J Cancer A 32A: 243-248, 1996

    Google Scholar 

  10. Yokoyama A, Nakai Y, Yoneda S, Kurita Y, Niitani H, Taguchi T: A late phase II study of Gemcitabine (LY 188011) against non-small cell lung cancer. Jpn J Cancer Chemother 23(12): 1681-1688, 1996

    Google Scholar 

  11. Lund B, Ryberg M, Petersen PM, Anderson H, Thatcher N, Dombernowsky P: Phase II study of Gemcitabine (2′.2′-difluorodeoxycytidine) given as a twice weekly schedule to previously untreated patients with non-small cell lung cancer. Ann Oncol 5: 852-853, 1994

    Google Scholar 

  12. Levitt ML, Fossella F, Devore RF, III: A randomized phase II study comparing two doses of Gemcitabine (Gem) in advanced or metastatic non-small cell lung cancer (NSCLC). Proc ASCO 17: 493a, 1998

    Google Scholar 

  13. Garfield DH, Dakhil SR, Whittaker TL, Keller AM: Phase II randomized multicenter trial of two dose schedules of Gemcitabine as second-line therapy in patients with advanced non-small cell lung cancer (ANSCLC). Proc ASCO 17: 484a, 1998

    Google Scholar 

  14. Fossella FV, Lippman SM, Shin DM, Tarassoff P, Calavag-Jung M, Perez-Soler R, Lee JS, Murphy WK, Glisson B, Rivera E, Hong WK: Maximum-tolerated dose defined for single-agent Gemcitabine: a phase I dose escalation study in chemotherapy-naive patients with advanced non-small cell lung cancer. J Clin Oncol 15(1): 310-316, 1997

    Google Scholar 

  15. Reddy GR, Gandara DR, Edelman MJ, Doroshow JH, Lau D, Lenz H, Israel V, Albain K, Jaslowski A, Lauder I, Conklin T, Maryon T: Gemcitabine (GEM) in Platinum (FLAT) treated non-small cell lung cancer (NSCLC). Proc ASCO 18: 521a, 1999

    Google Scholar 

  16. Crinò L, Mosconi AM, Scagliotti G, Selvaggi G, Novello S, Rinaldi N, Giulia MD, Gridelli C, Rossi A, Calandri C, De Marinis F, Noseda M, Tonato M: Gemcitabine as second-line treatment for advanced non-small cell lung cancer: a phase II trial. J Clin Oncol 17(7): 2081-2085, 1999

    Google Scholar 

  17. Rossi A, Perrone F, Barletta E, Tambaro R, Barzelloni ML, Scognamiglio F, Gatani T, Bilancia D, Maiorino L, Gridelli C: Activity of Gemcitabine (GEM) in Cisplatin-pretreated patients with advanced non-small cell lung cancer (NSCLC): a phase II trial. Proc ASCO 18: 484a, 1999

    Google Scholar 

  18. Manegold C, Bergman B, Chemaissani A, Dornoff W, Drings P, Kellokumpu-Lethinen P, Liippo K, Mattson K, v. Pavel J, Ricci S, Sederholm C, Stahel RA, Wagenius G, v. Walree N, Ten Bokkel-Huinink W: Single-agent Gemcitabine versus Cisplatin-Etoposide: Early results of a randomized phase II study in locally advanced or metastatic non-small cell lung cancer. Ann Oncol 8: 525-529, 1997

    Google Scholar 

  19. Perng RP, Chen YM, Ming-Liu J, Tsai CM, Lin WC, Yang KY, Whang-Peng J: Gemcitabine versus the combination of Cisplatin and Etoposide in patients with inoperable non-small cell lung cancer in a phase II randomized study. J Clin Oncol 15: 2097-2102, 1997

    Google Scholar 

  20. Anderson H, Tottier B, Nicolson M, Milroy R, Maughan T, Bond M, Falk S, Burt P, Carmichael J, Thatcher N on behalf of the Gemcitabine Study Group: Phase III study of Gemcitabine versus best supportive care in advanced non-small cell lung cancer. Lung Cancer 18 (Suppl 1): 9, 1997

    Google Scholar 

  21. Thatcher N, Anderson H, Ranson M, Lund B, Hansen H: Chemotherapy for symptom control in advanced NSCLC. Lung Cancer 18 (Suppl 2): 116, 1997

    Google Scholar 

  22. Medical Research Council by its Lung Cancer Working Party: Inoperable non-small cell lung cancer (NSCLC): a Medical Research Council randomized trial of palliative radiotherapy with two fractions or ten fractions. Br J Cancer 63: 265-270, 1991

    Google Scholar 

  23. Cullen M: The MIC-regimen in non-small cell lung cancer. Lung Cancer (Suppl 2): 81-89, 1993

    Google Scholar 

  24. Cortes-Funes H, Martin C, Abratt R, Lund B: Safety profile of Gemcitabine-a novel anticancer agent, in non-small cell lung cancer. Anti-Cancer Drugs 8: 582-587, 1997

    Google Scholar 

  25. Iglesias JL, Hatty S: Pulmonary safety of Gemcitabine (Gemzar®). Ann Oncol 7 (Suppl 5): 129-130, 1996

    Google Scholar 

  26. Pavlakis N, Levi JA, Wheeler HR, Begbie SD, Bell DR: Novel pulmonary and neurological (GNS) toxicities with Gemcitabine. Proc ASCO 15: 181, 1996

    Google Scholar 

  27. Underhill C, Parnis FX, Highley M, Ahern J, Lund B, Kamby C, Carmichael J, Harper P, Williams C, Hirsch F, Hansen M, Smith C, Walling J: A phase II study of Gemcitabine in previously untreated patients with advanced epithelial ovarian cancer (EOC). Ann Oncol 7 (Suppl 5): 69, 1996

    Google Scholar 

  28. Martin C, Ardizzoni A, Rosso R: Gemcitabine: Safety profile and efficacy in non-small cell lung cancer unaffected by age. Aging Clin Exp Res 9(4): 297-303, 1997

    Google Scholar 

  29. Abratt RP, Bezwoda WR, Goedhals L, Hacking DJ: Weekly Gemcitabine with monthly Cisplatin: Effective chemotherapy for advanced non-small cell lung cancer. J Clin Oncol 15(2): 744-749, 1997

    Google Scholar 

  30. Crinò L, Scagliotti G, Marangolo M, Figoli F, Clerici M, De Marinis F, Salvati F, Cruciani G, Dogliotti L, Pucci F, Paccagnella A, Adamo V, Altavilla G, Incoronato P, Trippetti M, Mosconi AM, Santucci A, Sorbolini S, Oliva C, Tonato M: Cisplatin-Gemcitabine combination in advanced non-small cell lung cancer: a phase II study. J Clin Oncol 15: 297-303, 1997

    Google Scholar 

  31. van Zandwijk N, Crinò, L, Kramer GW, Gans S, Schramel FM, Termeer A, Schlösser NJ, Postmus PE, Daamen S, van Glabbeke M, Giaggone G, The EORTC LCCG: Phase II study of Gemcitabine (GEM) plus Cisplatin (CIS) as induction regimen for patients with stage IIIA non-small cell lung cancer (NSCLC) by the EORTC Lung Cancer Cooperative Group (EORTC 08955). Proc ASCO 17: 468a, 1998

    Google Scholar 

  32. Sandler A, Nemunaitis J, Dehnam C, Cormier Y, von Pawel J, Niyikiza C, Nguyen B, Einhorn L: Phase III study of Cisplatin (C) with or without Gemcitabine (G) in patients with advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 454a, 1998

    Google Scholar 

  33. Ricci S, Antonuzzo A, Galli L, Bonifazi V, Lopes Pegna A, Algeri R, Petruzzelli S, Santomaggio C, Ghezzi P, Bertuccelli M, Tibaldi C, Innocenti F, Barsanti G, Roggi G, Conte PF: Combination chemotherapy with two different schedules of Gemcitabine (GEM) plus Cisplatin (CDDP) in patients with stage IIIB-IV NSCLC: a multicentric randomized phase II study. Proc ASCO 18: 480a, 1999

    Google Scholar 

  34. Cortesi E, Corona M, Gasperoni S, Grifalchi F, Lembo A, Moscetti L, Oliva A, Ramponi S, Padovani A: Decreased myelotoxicity of Gemcitabine and Cisplatin in advanced nonsmall cell lung cancer (NSCLC) with Cisplatin infusion on day 15. Proc ASCO 18: 493a, 1999

    Google Scholar 

  35. Green MR, Eisenberg P, Kosty M, Stolbach L, Hainsworth J, Zaknoen S: Activity and tolerability of Gemcitabine plus weekly Cisplatin in advanced non-small cell lung cancer UNSCLC. Proc ASCO 17: 468a, 1998

    Google Scholar 

  36. Lippe P, Silva RR, Monterubbianesi MC, Mari LGD, Cancellieri MA, Giacomini G, Santo A, Tummarello D, Rossi D, Cellerino R: Advanced non-small cell lung cancer (ANSCLC) in the elderly: symptoms-relief after weekly Gemcitabine (G) and Cisplatin (P). Proc ASCO 18: 514a, 1999

    Google Scholar 

  37. Cartei G, Sacco C, Cioschi B, Bearz A, Gusella M, Iop A, Vigevani E: Gemcitabine (G) and Platin (P) in advanced non-small cell lung cancer (NSCLC): A phase II study with emphasis on intention-to-treat analysis. Proc ASCO 17: 467a, 1998

    Google Scholar 

  38. Rinaldi M, Crinò L, Scagliotti G, Mosconi AM, De Marinis F, Gridelli C, Selvaggi G, Danvish S, Bartolucci R, Calandri C, Sassi M, Tonato M: A new schedule of Gemcitabine-Cisplatin in advanced non-small cell lung cancer (NSCLC) with two different Cisplatin dose levels: A phase II randomized trial. Proc ASCO 17: 470a, 1998

    Google Scholar 

  39. Bretti S, Celano A, Casadio C, Rovea P, Loddo C, Ritorto G, Bumma C: Gemcitabine and Cisplatin combination regimen in locally advanced or metastatic non-small cell lung cancer: A phase II study. Proc ASCO 17: 478a, 1998

    Google Scholar 

  40. Lippe P, Tummarello D, Monterubbianesi MC, Mari D, Silva RR, Giuliodori L, Santo A, Pasini E, Cetto GL, Cascinu S, Cellerino R: Weekly Gemcitabine (Gem) and Cisplatin (PL) in advanced non-small cell lung cancer (ANSCLC): A phase II study. Proc ASCO 17: 494a, 1998

    Google Scholar 

  41. Mazzanti P, Delprete S, Barrelli N, Barni S, Mattioli R, Scani A, De Signoribus G, Trivisonne R, Sanguinetti GM, Rossi G, Di Lullo L, Sturba F, Ardizzoia A, Imperatori I, La Verde N: Combination of Gemcitabine and Cisplatin in advanced nonsmall cell lung cancer (NSCLC): a phase II study. Proc ASCO 18: 517a, 1999

    Google Scholar 

  42. Gaafar Ei Hamza MR, Mansour O, Khaled H, El Serafi M, Gad el Mawla N: Front line treatment of advanced NSCLC with Cisplatin and Gemcitabine: a phase II study. Proc ASCO 18: 503a, 1999

    Google Scholar 

  43. Shepherd FA, Anglin G, Abratt R, Crinò L, Green M, Iglesias J, Sandler A, Steward W: Influence of Gemcitabine (Gem) and Cisplatin (CP) schedule on response and survival in advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 472a, 1998

    Google Scholar 

  44. Crinò L, Betti M, Gregore V, Darwish S, Minotti V, Calandri C, Scagliotti G, Novello S, Selvaggi G, Rinaldi M, Tonato M: Induction chemotherapy with Gemcitabine and Cisplatin in locally advanced stage III non-small cell lung cancer-a phase II study. Proc ASCO 18: 488a, 1999

    Google Scholar 

  45. Van Kooten M, Rosenberg M, Morero J, Chacón R, Orlando M: Phase II study of Gemcitabine (Gem) plus Cisplatin (Cis) as induction chemotherapy regimen for patients (pts) with Stage IIIA-IV non-small cell lung cancer (NSCLC)-preliminary report. Proc ASCO 18: 526a, 1999

    Google Scholar 

  46. Cueva JF, Grande C, Firvida JL, Amenedo M, Lázaro M, Romero C, Sabin P, Casal J, Garcia J, Barón FJ, Huidobro G, Salgado M, López R, González A, Castellanos J, Estévez SV, Candamio S, Mel JR, Vázquez R: A Lung Cancer Galician Group phase II trial: neoadjuvant Gemcitabine, Cisplatin and Vinorelbine for poor risk stage III non-small cell lung cancer. Proc ASCO 18: 500a, 1999

    Google Scholar 

  47. Vokes EE, Leopold KA, Herndon JE II, Crawford J, Perry MC, Miller AA, Green MR: A randomized phase II study of Gemcitabine or Paclitaxel or Vinorelbine with Cisplatin as induction chemotherapy (IndCT) and concomitant chemoradiotherapy (XRT), for unresectable stage III non-small cell lung cancer (NSCLC) (CALGB Study 9431). Proc ASCO 18: 459a, 1999

    Google Scholar 

  48. Yang CH, Tsai CM, Wang LS, Lee YC, Huang MH, Yen SW, Lui LT, Lu KT, Yang PC, Perng RP: A phase II feasibility trial of Gemcitabine (GEM) and Cisplatin (CDDP) before local treatment in locally advanced non-small cell lung cancer (NSCLC). Proc ASCO 18: 528a, 1999

    Google Scholar 

  49. Gandara DR, Edelman MJ, Lara P, Lau D: Current status and novel therapeutic approaches in advanced non-small cell lung cancer. ASCO-Educational Book 362-369, 1999

  50. Cardenal F, López-Cabrerizo MP, Antón A, Alberola V, Massuti B, Carrato A, Barneto I, Lomas M, Garcia M Lianes P, Montalar J, Vadell CI, González-Larriba JL, Nguyen B, Artal A, Rosell R: Randomized phase III study of Gemcitabine-Cisplatin versus Etoposide-Cisplatin in the treatment of locally advanced or metastatic non-small cell lung cancer. J Clin Oncol 17(1): 12-18, 1999

    Google Scholar 

  51. Crinò L, Conte P, De Marinis F, Rinaldi M, Gridelli C, Ceribelli A, Matano E, Marangolo M, Bartolucci R, Oliva C, Tonato M: A randomized trial of Gemcitabine, Cisplatin (GP) versus Mitomycin, Ifosfamide and Cisplatin (MIG) in advanced non-small cell lung cancer (NSCLC). A multicenter phase Im study. Proc ASCO 17: 455a, 1998

    Google Scholar 

  52. Carmichael J, Allerheiligen S, Walling J: A phase I study of Gemcitabine and Carboplatin in non-small cell lung cancer. Sem Oncol 23 (Suppl 10): 55-59, 1996

    Google Scholar 

  53. Pedersen AG: Phase I study of Gemcitabine combined with Carboplatin or Paclitaxel. Sem Oncol 24 (Suppl 7): 64-68, 1996

    Google Scholar 

  54. Carmichael J, Langley R, Osbourne L, Andrews L, Woll P, Stickland JE: A phase I study to investigate alternate sequencing of the combination Gemcitabine followed by Carboplatin in NSCLC. Eur J Cancer 33 (Suppl 8): 230, 1997

    Google Scholar 

  55. Martinez J, Panizo A, Alonso MA, Munoz J, De Cos Sánchez J, Sampedro JR, Hernández J: Gemcitabine plus Carboplatin in advanced non-small cell lung cancer (NSCLC): A phase I trial. Proc ASCO 17: 494a, 1998

    Google Scholar 

  56. Ng EW, Sandler AB, Einhorn LH: A phase II study of Carboplatin plus Gemcitabine in non-small cell lung cancer (NSCLC). Proc ASCO 17: 468a, 1998

    Google Scholar 

  57. Edelman MJ, Gandara DR, Lau D, Tracy D, Lauder I, Houston J, Davis UC: Sequential Carboplatin/Gemcitabine (C/G)-Paclitaxel (P) in advanced non-small cell lung cancer (NSCLC): an effective and well tolerated regimen. Proc ASCO 18: 502a, 1999

    Google Scholar 

  58. Jovtis S, Brocato N, Balbiani L, Temperley G, Zori Comba A, Rondinon M, Almira E, Bruno M, Maldonado D, Cavarra G, Martinez J, Orlando M: First-line therapy with Gemcitabine (GEMTRO®) (G) and Carboplatin (C) in patients (pts) with advanced non-small cell lung cancer (NSCLG): a phase II study. Proc ASCO 18: 1969, 1999

    Google Scholar 

  59. Gross G, Holiday D, Hampton J, Kieman H: A combination therapy of Gemcitabine (GEM) and Carboplatin (CBDCA) in advanced stage non-small cell lung carcinoma (NSCLC). Proc ASCO 18: 507a, 1999

    Google Scholar 

  60. Sederholm Ch: A phase IT study of Gemcitabine plus Carboplatin in chemonaive patients with advanced non-small cell lung cancer (NSCLC), Proc ASCO 18: 490a, 1999

    Google Scholar 

  61. Carrato A, García-Gómez J, Alberola V, Massuti BJ, Sánchez J, Juan O, Diaz-Fernández N, Galán A, Rodriguez-Lescure A, Means A, Gonzálvez ML, Gallego J: Carboplatin (CARBO) in combination with Gemcitabine (GEM) in advanced non-small cell lung cancer (NSCLC). Comparison of two consecutive phase II trials using different schedules. Proc ASCO 18: 498a, 1999

    Google Scholar 

  62. Georgoulias V, Androulakis N, Kouroussis Ch, Kakolyris S, Papadakis M, Agelidou M, Blazoyiannakis G, Gerogiannis A, Veslemes M, Agelidou A, Dimopoulos AM, Kotsakis Th, Souglakos J, Hatzidaki D: Second-line treatment with Paclitaxel (P) and Gemcitabine (G) in patients with nonsmall cell lung cancer (NSCLC) who failed Cisplatin-based chemotherapy. Proc ASCO 17: 468a, 1998

    Google Scholar 

  63. Giaccone G, Smit E, Laan D, Splinter T, van Meetbeck J, Postmus P: Phase I/II study of Paclitaxel and Gemcitabine in advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 486a, 1998

    Google Scholar 

  64. Garland LL, Wagner H, Shaw GS, Williams CC, Antonia SA, Khoor A, Meulemans LM, Nimmons KA, Ruckdeschel JC: Phase I dose-escalation study of constant rate infusion Gemcitabine in combination with Taxotere in advanced non-small cell lung cancer. Proc ASCO 17: 484a, 1998

    Google Scholar 

  65. Schlösser NJJ, Richel DJ, van Zandwijk N, Kroeze MA, Middel RPG, Schoot M: Phase I study of Docetaxel and Gemcitabine combination chemotherapy in chemotherapy-naïve patients with advanced or metastatic non-small cell lung cancer. Proc ASCO 17: 499a, 1998

    Google Scholar 

  66. Georgoulias V, Kouroussis Ch, Androulakis N, Kakolyris S, Dimopoulos AM, Papdakis E, Papadimitriou Ch, Hatzakis K, Bania E, Apostolopoulou F, Tsiafaki X, Alexopoulos A, Souglakos J, Kotsakis Th, Vlachonicolis J, Hatzidaki D: Front-line treatment of advanced non-small cell lung cancer (NSCLC) with Docetaxel (D) and Gemcitabine (G): A multicenter phase II trial. Proc ASCO 17: 473a, 1998

    Google Scholar 

  67. Herbst R, Dang N, Lynch C, Teicher B, Strauss G, Elias A, Anderson I, Salgia R, Jacobs C, Skarin A: Phase I study of combination weekly Gemcitabine and Vinorelbine in patients with lung cancer. Proc ASCO 17: 488a, 1998

    Google Scholar 

  68. Esteban E, Llano JLG, Vieitez JM, Fra J, Puertas J, Estrada E, Palacio I, Muniz I, Buesa JM, Lacave AJ: Phase I/II study of Gemcitabine plus Vinorelbine in non-small cell lung cancer (NSCLC). Proc ASCO 17: 482a, 1998

    Google Scholar 

  69. Isokangas OP, Mattson K, Joensuu H, Tamminen K, Nikkanen V, Viren M, Brisgand D, Barbet I: A phase II study of Vinorelbine (VNR) and Gemcitabine (GEM) in inoperable stage IIIB-IV NSCLC. Proc ASCO 17: 489a, 1998

    Google Scholar 

  70. Lorusso V, Mancarella S, Carpagnano F, Di Rienzo, Cisternino L, Napoli G, Orlando S, Cinieri S, Brunetti C, Palazzo S, Catino A, Paradiso A, Panza N, De Cataldis G, Frasci G, De Lena M: Gemcitabine plug Vinorelbine in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). A phase II study. Proc ASCO 17: 470a, 1998

    Google Scholar 

  71. Lilenbaum RC, Schwartz MA, Cano R, Krill E, Lutzky J, Blaustein A, Seigel L, Viales M, Dominguez CJ, Davila E: Gemcitabine (Gem) and Navelbine (NVB) in advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 494a, 1998

    Google Scholar 

  72. Chen YM, Whang-Peng J, Perng RP, Liu TW, Yang KY, Lin WC, Wu HW, Shih JF, Liu JM, Chen LT, Tsai CM: A multicenter phase II study of Gemcitabine (GEM) and Vinorelbine (VMR) in patients with advanced stage IIIB-IV non-small cell lung cancer. Proc ASCO 18: 481a, 1999

    Google Scholar 

  73. Pirker R, Krajnik G, Mohn-Staudner A, Thaler J, Greil R, Schmeikal S, Marhold F, Deutsch J, Preiss P, Wein W, Malayeri R, Huber H: Vinorelbine/Gemcitabine in advanced nonsmall cell lung cancer (NSCLC): an AASLC phase II trial. Proc ASCO 18: 479a, 1999

    Google Scholar 

  74. Hirsh V, Ayoub J, Cormier Y, Kerby W, Iglesia J: Phase II multicenter trial with Gemcitabine and Vinorelbine in patients with advanced (stage IIIB + IV) non-small cell lung cancer. Proc ASCO 18: 408a, 1999

    Google Scholar 

  75. Herbst RS, Khuri FR, Jung M, Fossella FV, Lee JS, Glisson B, Shin DM, Pisters K, Papadimitrakopoulou V, Kurie J, Perez-Soler R, Liu D, Munden R, Hong WK: Phase II study of combination weekly Gemcitabine and Vinorelbine in patients with untreated or previously treated non-small cell lung cancer. Proc ASCO 18: 462a, 1999

    Google Scholar 

  76. Gridelli C, Frontini L, Gulisano M, Cigolari S, Castiglione F, Robbiati SF, Farris A, Ianniello GP, Clerici M, Felletti R, Piazza E, Rossi A, Gallo C, Perrone F, on behalf of the GemVin Investigators: Optimal doses of Gemcitabine + Vinorelbine (Gemvin) in the treatment of advanced non-small cell lung cancer (NSCLC). A "keep-the-winner" phase II study. Proc ASCO 18: 477a, 1999

    Google Scholar 

  77. Barr F, Mirsky H, Clinthorne D, Bendel S, Smith F: A phase III study of Gemcitabine and Vinorelbine salvage chemotherapy for taxane resistant non-small cell lung cancer (NSCLC). Proc ASCO 18: 469a, 1999

    Google Scholar 

  78. Gian V, Hainsworth JD, Burris HA, Erland JB, Brown CP, Rinaldi DA, Greco FA: Combination Gemcitabine and Vinorelbine in the second-line treatment of non-small cell lung cancer (NSCLC): a phase II study of the Minnie Pearl Cancer Research Network. Proc ASCO 18: 505a, 1999

    Google Scholar 

  79. Eberhard W, Wilke H, Manegold C, Gatzemeier U, Blatter J, Drings P, Seeber S: Phase I dose finding study of gemcitabine (GEM) and ifosfamid (IFO) in advanced non-small cell lung cancer (NSCLC). Proc ASCO 14: 351, 1995

    Google Scholar 

  80. Gatzemeier U, Manegold C, Eberhard W, Wilke HJ, Chomy F, Chomy P, Khayat D, Blatter J, Seeber S, Drings P: Ifosfamide and Gemcitabine: a phase II trial in advanced inoperable nonsmall cell lung cancer. Sem Oncol 25 (Suppl 2): 15-18, 1998

    Google Scholar 

  81. Rocha Lima CM, Perkel JA, Putman-Hair T, Sherman CA Leong SS, Green MR: Ongoing phase I study of Irinotecan (CPT 11) and Gemcitabine (GEM). Proc ASCO 17: 250a, 1998

    Google Scholar 

  82. Dabrow MB, Gilman PB, Meyer TJ et al.: Combined therapy with Topotecan and Gemcitabine in patients with inoperable or metastatic non-small cell lung cancer. Proc ASCO 18: 500a, 1999

    Google Scholar 

  83. Cole JL, Rinaldi DA, Lormand NA, Brierre TE, Brnes B, Fontenot MF, Buller EJ, Rainey JM: A phase I-II trial of Topotecan (TOP) and Gemcitabine (GEM) for patients with previously treated, advanced non-small cell lung cancer (NSCLC). Proc ASCO 18: 499a, 1999

    Google Scholar 

  84. Gralla FJ, Rittenberg CN, Silverman CR, Marques CB, Maulick JF, Cole JT: Gemcitabine (G) + Vinorelbine (V) in combination with Mitomycin (M) in non-small cell lung cancer (NSCLC): Results of a phase I and phase II study of an active outpatient regimen. Proc ASCO 17: 486a, 1998

    Google Scholar 

  85. González Barón M, Garcia MJ, Chacón JI, Ordónez A, Madronal C, Murias A, Cruz MA, De Castro J, Feliu J, Colmenarejo A, Aguiar J: A phase II study of Gemcitabine, Cisplatin and Vinorelbine in patients with advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 469a, 1998

    Google Scholar 

  86. Boni C, Bisagni G, Savoldi L, Franciosi V, Pezzola A, De Bas T: Gemcitabine, Tfosfamide, Cisplatin (GIP) for the treatment of stage III-IV non-small cell lung cancer (NSCLC). Proc ASCO 17: 478a, 1998

    Google Scholar 

  87. Castellano D, Lianes P, Calzas J, Garcia-Carbonero R, Guerra JA, Gómez H, Cortés-Funes H: Non-Cisplatin-based chemotherapy for advanced non-small cell lung cancer (NSCLC): A phase II study with Gemcitabine (G), Ifosfamide (I) and Vinorelbine (N). Proc ASCO 17: 480a, 1998

    Google Scholar 

  88. Dorta J, Martin G, Constenla M, Lizón J, León A, Cruz JJ, Lorenzo I, González Barón M, Garcia Puche JL: A phase II study of Gemcitabine, Cisplatin and Vinorelbine in patients with advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 482a, 1998

    Google Scholar 

  89. Baldini E, Ardizzoni A, Cafferata MA, Boni L, Tibaldi C, Chella A, Conte PF, Rosso R: Combined Gemcitabine, Ifosfamide and Vinorelbine (GIN): activity and safety of a non-platinum-based regimen in advanced non-small cell lung cancer (NSCLC). Proc ASCO 18: 595a, 1999

    Google Scholar 

  90. Recchia F, De Filippis S, Saggio G, Guerriero G, Rosselli M, Amiconi G, Rea S: Phase II study of Gemcitabine, Ifosfamide and Vinorelbine in advanced non-small cell lung cancer. Activity and toxicity of a platinum-free regimen. Proc ASCO 18: 489a, 1999

    Google Scholar 

  91. Comella G, Frasci G, Panza N, Bianco A, Maiorino L, Curcio C, Belli M, Cioffi R, De Cataldis G, Manzione L, Bilancia D, De Lena M, Di Rienzo G, Pizza C, Contu A, Massidda B, Mascia V, Salaris G, Muci D, Palazzo S, Jirillo A, Pacilio C, Comella P: Cisplatin + Gemcitabine + Vinorelbine (PGV) vs Cisplatin + Vinorelbine (PV) vs Cisplatin + Gemcitabine (PG) in advanced non-small cell lung cancer (NCSLC). Interim analysis of a Southern Italy Cooperative Oncology Group (SICOG) phase III trial. Proc ASCO 18: 486a, 1999

    Google Scholar 

  92. Hainsworth JD, Briand JB, Kalman LA, Hon JK, Smith SW, Greco FA: Phase I/II trial of Paclitaxel (1-hour infusion), Carboplatin and Gemcitabine in the treatment of advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 471a, 1998

    Google Scholar 

  93. Frasci G, Comella P, Panza N, Pacilio C, Nicoletta GP, Natale M, Manzione L, Gravina A, Cioffi R, Maiorino L, Comella G: Cisplatin-Gemcitabine-Paclitaxel in advanced non-small cell lung cancer (NSCLC). A dose-finding study. Proc ASCO 17: 481a, 1998

    Google Scholar 

  94. Kelly K, Prindiville S, Bunn Jr PA: A phase I trial of Paclitaxel (P), Carboplatin (C), and Gemcitabine (G) in advanced nonsmall cell lung cancer (NSCLC). Proc ASCO 17: 490a, 1998

    Google Scholar 

  95. Sorensen JB, Stenbyggard LE, Hansen HH, Dombernowsky P: Biweekly Paclitaxel, Gemcitabine and Cisplatin in nonresectable non-small cell lung cancer (NSCLC). Proc ASCO 17: 501a, 1998

    Google Scholar 

  96. Zinner R, Fossella FV, Komaki R, Delclos M, Jung M, Glisson BS, Lee JS, Pisters K, Jhingran A, Hong WK: Phase I trial of concurrent Gemcitabine (G) plus chest radiotherapy (XRT), followed by consolidation systemic chemotherapy with G plus Cisplatin (CDDP), for patients with stage III and medically inoperable stage II non-small cell lung cancer (NSCLC). Proc ASCO 18: 466a, 1999

    Google Scholar 

  97. Blackstock AW, Richards FR, Lovelace JR, Lesser GJ, Tucker RW, Case LD, White DR: Twice-weekly Gemcitabine and concurrent thoracic radiotherapy-a phase I/II study in patients with advanced non-small cell lung cancer. Proc ASCO 18: 497a, 1999

    Google Scholar 

  98. Gregor A, Price A, Van der Leest AHD, Scalliet P, Wets M, Jungnelius U, Lemmens JP, Groen HJM: Phase I study of Gemcitabine and Radiotherapy in stage III non-small cell lung cancer. Proc ASCO 18: 506a, 1999

    Google Scholar 

  99. Scalliet P, Goor C, Galdermans D, Van Meerbeck J, Groen HJM, Van der Leest AHD, Westerink H, Jungnelius U, Turrisi A: Gemzar® (Gemcitabine) with thoracic radiotherapy-a phase II pilot study in chemo-naïve patients with advanced non-small cell lung cancer (NSCLC). Proc ASCO 17: 499a, 1998

    Google Scholar 

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Authors and Affiliations

  1. Thoraxklinik der LVA, University Teaching Hospital, Heidelberg, Germany

    Christian Manegold

  2. Faculty Hospital Na Bulovce, Charles University and Postgraduate Medical School, 3rd Faculty of Medicine, Prague, Czech Republic

    Petr Zatloukal

  3. Eli Lilly GmbH, Area Medical Center, Vienna, Austria

    Kurt Krejcy

  4. Lilly Deutschland GmbH, Bad Homburg, Germany

    Johannes Blatter

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  1. Christian Manegold
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  4. Johannes Blatter
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Manegold, C., Zatloukal, P., Krejcy, K. et al. Gemcitabine in Non-Small Cell Lung Cancer (NSCLC). Invest New Drugs 18, 29–42 (2000). https://doi.org/10.1023/A:1006327729228

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