Abstract
We report for the first time a measured volumetric reduction of a choroid plexus carcinoma utilizing preoperative chemotherapy. Histologically proven choroid plexus carcinoma was diagnosed in a fifteen month old female. She was treated with three courses of chemotherapy including etoposide (VP16), cyclophosphamide, vincristine, and cisplatin. Computer-assisted three dimensional reconstruction of the tumor volume was performed prior to and after three courses of chemotherapy. An overall reduction of 29.5% of tumor volume was accomplished preoperatively. Staged surgical procedures resulted in a complete resection of her lesion and she has remained disease-free for 31 months. A volumetric measurement as a response to preoperative chemotherapy may prove valuable in determining future optimal treatment regimens for choroid plexus carcinoma of childhood.
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Ellenbogen RG, Winston KR, Kupsky WJ: Tumors of the choroid plexus in children. Neurosurg 25: 327–335, 1989
Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA, Ryan J, Reaman G, Schut L: Choroid plexus carcinoma of childhood. Cancer 69: 581–585, 1992
Pierga JY, Kalifa C, Terrier-Lacombe MJ: Carcinoma of the choroid plexus: a pediatric experience. Med Ped Oncol 21: 480–487, 1993
Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Khan A, Bouffet E: Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurg 42: 470–475, 1998
Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S, Meyer P, Cinalli C, Zerah M, Peirre-Kahn A, Renier D: Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88: 521–528, 1998
St. Clair SK, Humphreys RP, Pillay PK, Hoffman HJ, Blaser SI, Becker LE: Current management of choroid plexus carcinoma in children. Ped Neurosurg 17: 225–233, 1991–92
Razzaq AA, Cohen AR: Neoadjuvant chemotherapy for hypervascular malignant brain tumors of childhood. Ped Neurosurg 27: 296–303, 1997
Duffner PK, Kun LE, Burger PC, Horowitz ME, Cohen ME, Sanford RA, Krischer JP, Mulhern RK, James HE, Rekate HL, Friedman HS: Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. Ped Neurosurg 22: 189–196, 1995
Allen J, Wisoff J, Helson L, Pearce J, Arenson E: Choroid plexus carcinoma responses to chemotherapy alone in newly diagnosed young children. J Neurooncol 12: 69–74, 1992
Arico M, Emanuela R, Bossi G, Giordana MT, Corbella F, Locatelli D, Pezzotta S: Choroid plexus carcinoma: report of one case with favourable response to treatment. Med Ped Oncl 22: 274–278, 1994
Medary I, Aronson D, Cheung N-KV, Ghavimi F, GeraldW, LaQuaglia MP: Kinetics of primary tumor regression with chemotherapy: implications for the timing of surgery. Ann Surg Oncol 3: 521–525, 1996
Vaidyanathan M, Clarke LP, Hall LO, Heidtman C, Velthuizen R, Gosche K, Phuphanich S, Wagner H, GreenbergH, SilbigerML:Monitoring brain tumor response to therapy using MRI segmentation. Magn Reson Imaging 15: 323–334, 1997
Clarke LP, Velthuizen RP, Clark M, Gaviria J, Hall L, Goldgof D, Murtagh, Phuphanich S, Brem S: MRI measurement of brain tumor response: comparison of visual metric and automatic segmentation. Magn Reson Imaging 16: 271–279 1998
Shi W-M, Wildrick DM, Sawaya R: Volumetric measurement of brain tumors from MR imaging J Neuro-Oncol37: 87–93, 1998
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Souweidane, M.M., Johnson, J.H. & Lis, E. Volumetric Reduction of a Choroid Plexus Carcinoma Using Preoperative Chemotherapy. J Neurooncol 43, 167–171 (1999). https://doi.org/10.1023/A:1006229732653
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DOI: https://doi.org/10.1023/A:1006229732653