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Basic kinetics of 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (BMIPP) in canine myocardium

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Abstract

BMIPP is a radioiodinated fatty acid analogue used for myocardial single photon emission CT (SPECT) imaging based on high cardiac fatty acid metabolism. In normal dogs, 74% of the injected BMIPP was instantly extracted and was then retained in 65.3%. The washout of the retained radioactivity was low, and most of the washout was alpha- and beta-oxidation metabolites. ATP concentration plays an important role in the myocardial uptake and retention of BMIPP. The ATP-dependent BMIPP uptake at the TG pool was strongly regulated by etomoxir with modifying mitochondrial β-oxidation and subsequent ATP production. Thus, myocardial viability was reflected on the BMIPP uptake in acute ischemia. In spite of in-significant changes in early extraction and retention, BMIPP back diffusion (r=−0.92) and full-oxidation metabolite (r=0.78) were correlated with the severity of ischemia. Mismatched region of BMIPP with flow (Tl-201) showed decreased metabolic enzymes such as citrate synthase and 3-hydroxyacyl-CoA dehydrogenase. These data suggest that BMIPP would be feasible for detecting cellular energy state from lipid metabolism.

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Authors and Affiliations

  1. Graduate School of Medicine, Department of Cardiovascular Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyo-ku, Kyoto, 606, Japan

    Ryuji Nohara, Ryohei Hosokawa, Taku Hirai, Kazumi Okuda, Motonari Ogino, Yasuhisa Fujibayashi, Masatoshi Fujita & Shigetake Sasayama

Authors
  1. Ryuji Nohara
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  2. Ryohei Hosokawa
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  3. Taku Hirai
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  4. Kazumi Okuda
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  5. Motonari Ogino
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  6. Yasuhisa Fujibayashi
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  7. Masatoshi Fujita
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  8. Shigetake Sasayama
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Nohara, R., Hosokawa, R., Hirai, T. et al. Basic kinetics of 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (BMIPP) in canine myocardium. Int J Cardiovasc Imaging 15, 11–20 (1999). https://doi.org/10.1023/A:1006167713330

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